PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32926257-7	2022	Morphine and fentanyl activated NLRP3 inflammasome in astrocytes and serotonergic (TPH-2-positive) neurons, but fentanyl effects were more pronounced.	Fentanyl	13-21	NLR family pyrin domain containing 3	Homo sapiens	32-37	
32926257-11	2022	The anti-inflammatory agent minocycline and the NLRP3 inhibitor MCC950 delayed tolerance to morphine and fentanyl antinociception and prevented fentanyl-induced hyperalgesia.	Fentanyl	105-113	NLR family pyrin domain containing 3	Homo sapiens	48-53	
32926257-11	2022	The anti-inflammatory agent minocycline and the NLRP3 inhibitor MCC950 delayed tolerance to morphine and fentanyl antinociception and prevented fentanyl-induced hyperalgesia.	Fentanyl	144-152	NLR family pyrin domain containing 3	Homo sapiens	48-53	
32926257-13	2022	In conclusion, morphine and fentanyl differentially induce cell-specific activation of NLRP3 inflammasome and pyroptosis in the DRN through TLR4 receptors in astrocytes and through opioid receptors in neurons, indicating that neuroinflammation is involved in opioid-induced analgesia and fentanyl-induced hyperalgesia after repeated administrations.	Fentanyl	28-36	NLR family pyrin domain containing 3	Homo sapiens	87-92	
32926257-13	2022	In conclusion, morphine and fentanyl differentially induce cell-specific activation of NLRP3 inflammasome and pyroptosis in the DRN through TLR4 receptors in astrocytes and through opioid receptors in neurons, indicating that neuroinflammation is involved in opioid-induced analgesia and fentanyl-induced hyperalgesia after repeated administrations.	Fentanyl	288-296	NLR family pyrin domain containing 3	Homo sapiens	87-92