PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16495443-2 2006 Recent work has demonstrated that DHPG-induced LTD recruits at least two signal transduction pathways known to couple to translation, the mitogen-activated protein kinase kinase (MEK)-extracellular signal-regulated kinase (ERK) signaling pathway and the phosphoinositide 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) signaling pathway. dhpg 34-38 mechanistic target of rapamycin kinase Homo sapiens 322-326 16495443-5 2006 We found that both the MEK-ERK and PI3K-mTOR signaling pathways are critical for the DHPG-induced regulation of these translation factors. dhpg 85-89 mechanistic target of rapamycin kinase Homo sapiens 40-44 16495443-7 2006 Our results provide direct evidence that cap-dependent translation is engaged during mGluR-LTD and demonstrate that the MEK-ERK and PI3K-mTOR signaling pathways converge to regulate eIF4E activity after induction of DHPG-LTD. dhpg 216-220 mechanistic target of rapamycin kinase Homo sapiens 137-141