PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22223343-7 2012 Mice given a histamine H1-receptor antagonist [fexofenadine (peripherally acting) or pyrilamine (peripherally and centrally acting)] or an irreversible HDC inhibitor (alpha-fluoromethylhistidine) displayed less PW endurance than control mice. alpha-fluoromethylhistidine 167-194 histidine decarboxylase Mus musculus 152-155 9831923-9 1998 An irreversible inhibitor of HDC, alpha-fluoromethylhistidine, partially inhibited the accumulation in the later period. alpha-fluoromethylhistidine 34-61 histidine decarboxylase Mus musculus 29-32 16061728-8 2005 Their production was enhanced when histamine synthesis was blocked by the specific HDC inhibitor alpha-fluoro-methyl histidine, and underscored the determinant role of histamine in the inhibitory effect. alpha-fluoromethylhistidine 97-126 histidine decarboxylase Mus musculus 83-86 10604837-6 1999 administration of alpha-fluoromethylhistidine (FMH), a specific and irreversible inhibitor of histidine decarboxylase, on leptin-induced suppression of food intake in normal C57BL strain mice. alpha-fluoromethylhistidine 18-45 histidine decarboxylase Mus musculus 94-117 10604837-6 1999 administration of alpha-fluoromethylhistidine (FMH), a specific and irreversible inhibitor of histidine decarboxylase, on leptin-induced suppression of food intake in normal C57BL strain mice. alpha-fluoromethylhistidine 47-50 histidine decarboxylase Mus musculus 94-117 12196593-7 2002 In WT mice, indeed, intraperitoneal injection of alpha-fluoromethylhistidine (HDC-inhibitor) caused a decrease in W, whereas injection of ciproxifan (HA-H3 receptor antagonist) elicited W. Both injections had no effect in HDC-/-mice. alpha-fluoromethylhistidine 49-76 histidine decarboxylase Mus musculus 78-81 10711350-6 2000 alpha-Fluoromethylhistidine, a suicide substrate of L-histidine decarboxylase (HDC), suppressed the thapsigargin (30 nM)- and TPA (30 nM)-induced histamine production. alpha-fluoromethylhistidine 0-27 histidine decarboxylase Mus musculus 52-77 10711350-6 2000 alpha-Fluoromethylhistidine, a suicide substrate of L-histidine decarboxylase (HDC), suppressed the thapsigargin (30 nM)- and TPA (30 nM)-induced histamine production. alpha-fluoromethylhistidine 0-27 histidine decarboxylase Mus musculus 79-82 7796129-5 1995 On the other hand, the histidine decarboxylase inhibitor, alpha-fluoromethylhistidine (alpha-FMH), significantly potentiated the morphine (1 mg/kg)-induced place preference. alpha-fluoromethylhistidine 58-85 histidine decarboxylase Mus musculus 23-46 9579727-16 1998 The effect of 500 mg kg(-1) L-histidine was completely prevented by the selective histidine decarboxylase inhibitor, (S)-alpha-fluoromethylhistidine (50 mg kg(-1), i.p. alpha-fluoromethylhistidine 117-148 histidine decarboxylase Mus musculus 82-105 8788860-1 1995 We examined the long-term effects of administration of (S)-alpha-fluoromethylhistidine (FMH), a specific inhibitor of histidine decarboxylase, on the spontaneous locomotor activity, food intake and brain contents of histamine, catecholamines, serotonin and amino acids of ICR mice. alpha-fluoromethylhistidine 55-86 histidine decarboxylase Mus musculus 118-141 8750797-5 1995 This ameliorating effect of histidine was abolished by alpha-fluoromethylhistidine, an inhibitor of histidine decarboxylase, suggesting that histidine itself has no such ameliorating effect. alpha-fluoromethylhistidine 55-82 histidine decarboxylase Mus musculus 100-123 7774858-7 1995 Alpha-fluoromethylhistidine, a suicide inhibitor of HDC, suppressed LPS-induced cytokine production. alpha-fluoromethylhistidine 0-27 histidine decarboxylase Mus musculus 52-55 7796129-5 1995 On the other hand, the histidine decarboxylase inhibitor, alpha-fluoromethylhistidine (alpha-FMH), significantly potentiated the morphine (1 mg/kg)-induced place preference. alpha-fluoromethylhistidine 87-96 histidine decarboxylase Mus musculus 23-46 2838862-1 1988 The effect of alpha-fluoromethylhistidine (alpha-FMH), a specific inhibitor of histidine decarboxylase, on the potentiation of thiopental-induced sleep by delta 9-tetrahydrocannabinol (THC), which inhibits the histamine turnover in the brain, was examined in mice and rats. alpha-fluoromethylhistidine 14-41 histidine decarboxylase Mus musculus 79-102 35429681-11 2022 This beneficial effect of histidine on memory was cancelled by intracerebroventricular injection of the HDC inhibitor alpha-fluoromethylhistidine. alpha-fluoromethylhistidine 118-145 histidine decarboxylase Mus musculus 104-107 2470944-3 1989 The HA turnover, measured either by the accumulation of t-MH after pargyline injection or by the HA depletion after the treatment with alpha-fluoromethylhistidine, a specific inhibitor of histidine decarboxylase, was enhanced by the exposure to tail pinch, like the enhancement produced by the exposure to foot shock. alpha-fluoromethylhistidine 135-162 histidine decarboxylase Mus musculus 188-211 2312155-3 1990 Alpha-fluoromethylhistidine, a suicide inhibitor of HDC, attenuated, in a dose-dependent manner, both spontaneous and LPS-stimulated IL-1 synthesis by macrophages. alpha-fluoromethylhistidine 0-27 histidine decarboxylase Mus musculus 52-55 2838862-1 1988 The effect of alpha-fluoromethylhistidine (alpha-FMH), a specific inhibitor of histidine decarboxylase, on the potentiation of thiopental-induced sleep by delta 9-tetrahydrocannabinol (THC), which inhibits the histamine turnover in the brain, was examined in mice and rats. alpha-fluoromethylhistidine 43-52 histidine decarboxylase Mus musculus 79-102 2824613-3 1987 Histidine-free culture conditions or addition of alpha-fluoromethylhistidine, an irreversible inhibitor of histidine decarboxylase, completely abrogate this phenomenon, indicating that increased histamine levels result from an augmentation of the rate of its synthesis. alpha-fluoromethylhistidine 49-76 histidine decarboxylase Mus musculus 107-130 2948614-3 1986 Footshock significantly enhanced the HA depletion induced by alpha-fluoromethylhistidine, a specific inhibitor of histidine decarboxylase. alpha-fluoromethylhistidine 61-88 histidine decarboxylase Mus musculus 114-137 6693900-6 1984 Since neuronal histamine levels are maintained only by continued histidine decarboxylase activity, complete inhibition of this enzyme by alpha-fluoromethylhistidine, a "suicide" inhibitor of histidine decarboxylase, would totally deplete W/Wv mice of brain histamine. alpha-fluoromethylhistidine 137-164 histidine decarboxylase Mus musculus 65-88 3761755-4 1986 Muscimol and AOAA also inhibited decrease in the histamine (HA) level induced by alpha-fluoromethylhistidine (50 mg/kg), a specific inhibitor of histidine decarboxylase. alpha-fluoromethylhistidine 81-108 histidine decarboxylase Mus musculus 145-168 3713874-3 1986 In mice pretreated with alpha-fluoromethylhistidine, an inhibitor of histidine decarboxylase, PCP produced a marked hyperthermia. alpha-fluoromethylhistidine 24-51 histidine decarboxylase Mus musculus 69-92 3841376-0 1985 Effects of alpha-fluoromethylhistidine on increase in histidine decarboxylase activity of maternal mouse kidney observed during late pregnancy and evidence for its non-mast cell origin by using estrogen and W/WV mice. alpha-fluoromethylhistidine 11-38 histidine decarboxylase Mus musculus 54-77 3841376-2 1985 administration of 25 mg/kg of alpha-fluoromethylhistidine (alpha-FMH), a suicide inhibitor of HDC, starting on day 13 of pregnancy. alpha-fluoromethylhistidine 30-57 histidine decarboxylase Mus musculus 94-97 3841376-2 1985 administration of 25 mg/kg of alpha-fluoromethylhistidine (alpha-FMH), a suicide inhibitor of HDC, starting on day 13 of pregnancy. alpha-fluoromethylhistidine 59-68 histidine decarboxylase Mus musculus 94-97 6472496-7 1984 This assay was used to determine the in vivo changes in mouse brain histidine decarboxylase activity following irreversible inhibition with (+) alpha-fluoromethylhistidine (alpha-FMH). alpha-fluoromethylhistidine 140-171 histidine decarboxylase Mus musculus 68-91 6472496-7 1984 This assay was used to determine the in vivo changes in mouse brain histidine decarboxylase activity following irreversible inhibition with (+) alpha-fluoromethylhistidine (alpha-FMH). alpha-fluoromethylhistidine 173-182 histidine decarboxylase Mus musculus 68-91 6693900-6 1984 Since neuronal histamine levels are maintained only by continued histidine decarboxylase activity, complete inhibition of this enzyme by alpha-fluoromethylhistidine, a "suicide" inhibitor of histidine decarboxylase, would totally deplete W/Wv mice of brain histamine. alpha-fluoromethylhistidine 137-164 histidine decarboxylase Mus musculus 191-214 7160183-0 1982 Effect of alpha-monofluoromethyl histidine, an irreversible inhibitor of histidine decarboxylase, on gestation in mice. alpha-fluoromethylhistidine 10-42 histidine decarboxylase Mus musculus 73-96 6864215-2 1983 The effects of alpha-fluoromethylhistidine (alpha-FMH) on the HDC activity and histamine content of the brain of W/Wv and +/+ mice were examined. alpha-fluoromethylhistidine 44-53 histidine decarboxylase Mus musculus 62-65 6864215-4 1983 injection of alpha-FMH the HDC activity of the brain had decreased to 10% of that in untreated mice. alpha-fluoromethylhistidine 13-22 histidine decarboxylase Mus musculus 27-30 7160183-1 1982 Chronic administration of alpha-monofluoromethyl histidine, a specific inhibitor of histidine decarboxylase, to pregnant mice blocked histidine decarboxylase activity and markedly depleted histamine levels in 18-day-old foetuses and in newborn mice. alpha-fluoromethylhistidine 26-58 histidine decarboxylase Mus musculus 84-107 7160183-1 1982 Chronic administration of alpha-monofluoromethyl histidine, a specific inhibitor of histidine decarboxylase, to pregnant mice blocked histidine decarboxylase activity and markedly depleted histamine levels in 18-day-old foetuses and in newborn mice. alpha-fluoromethylhistidine 26-58 histidine decarboxylase Mus musculus 134-157 27833003-2 2017 We analysed the effect of acute histamine depletion by means of i. c.v. injections of alpha-fluoromethylhistidine, a blocker of histidine decarboxylase, on the temporal organization of motor sequences of CD1 mice behaviour in the open-field test. alpha-fluoromethylhistidine 86-113 histidine decarboxylase Mus musculus 128-151 7126249-0 1982 Effect of alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase, on histamine levels in mouse tissues. alpha-fluoromethylhistidine 10-37 histidine decarboxylase Mus musculus 62-85 7452304-1 1980 alpha-Fluoromethylhistidine (alpha-FMH), a new potent inhibitor of histidine decarboxylase (HD), has been used for in vitro and in vivo studies of brain HD. alpha-fluoromethylhistidine 0-27 histidine decarboxylase Mus musculus 67-90 7452304-1 1980 alpha-Fluoromethylhistidine (alpha-FMH), a new potent inhibitor of histidine decarboxylase (HD), has been used for in vitro and in vivo studies of brain HD. alpha-fluoromethylhistidine 29-38 histidine decarboxylase Mus musculus 67-90 23773488-5 2013 In addition, a depletion of endogenous histamine with alpha-fluoromethylhistidine (alpha-FMH), a specific HDC inhibitor, or feeding mice a low-histamine diet also enhanced nociception in the wild-types. alpha-fluoromethylhistidine 54-81 histidine decarboxylase Mus musculus 106-109 25562630-5 2015 The protective effect of carnosine or histidine was completely abolished by alpha-fluoromethylhistidine (alpha-FMH), a selective and irreversible histidine decarboxylase inhibitor, or in histidine decarboxylase deficient (HDC-KO) mice. alpha-fluoromethylhistidine 76-103 histidine decarboxylase Mus musculus 146-169 25562630-5 2015 The protective effect of carnosine or histidine was completely abolished by alpha-fluoromethylhistidine (alpha-FMH), a selective and irreversible histidine decarboxylase inhibitor, or in histidine decarboxylase deficient (HDC-KO) mice. alpha-fluoromethylhistidine 105-114 histidine decarboxylase Mus musculus 146-169 23773488-5 2013 In addition, a depletion of endogenous histamine with alpha-fluoromethylhistidine (alpha-FMH), a specific HDC inhibitor, or feeding mice a low-histamine diet also enhanced nociception in the wild-types. alpha-fluoromethylhistidine 83-92 histidine decarboxylase Mus musculus 106-109 23127196-9 2012 alpha-Fluoromethylhistidine (100 mumol/L), a selective and irreversible inhibitor of histidine decarboxylase, also significantly inhibited the protective effects of carnosine. alpha-fluoromethylhistidine 0-27 histidine decarboxylase Mus musculus 85-108