PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17760865-3 2007 This TRH-induced suppression of food intake was attenuated partially in histamine-depleted rats pre-treated with alpha-fluoromethylhistidine (a specific suicide inhibitor of histidine decarboxylase) and in mice with targeted disruption of histamine H1 receptors. alpha-fluoromethylhistidine 113-140 histidine decarboxylase Rattus norvegicus 174-197 18474684-13 2008 In agreement, both imidazole H3R antagonists, a nonimidazole H3R antagonist, and the HDC inhibitor alpha-monofluoromethyl histidine increased cell proliferation (up to approximately 60%), revealing a H3R-mediated inhibition by endogenous HA. alpha-fluoromethylhistidine 99-131 histidine decarboxylase Rattus norvegicus 85-88 10893046-7 2000 This activity was completely inhibited by (S)-alpha-fluoromethylhistidine, a specific inhibitor of HDC. alpha-fluoromethylhistidine 42-73 histidine decarboxylase Rattus norvegicus 99-102 17531387-7 2007 In experiment 3, we intraperitoneally injected fluoromethylhistidine (FMH), an antagonistic inhibitor of HDC, in rats fed with a histidine-enriched diet. alpha-fluoromethylhistidine 70-73 histidine decarboxylase Rattus norvegicus 105-108 17169331-4 2007 The protection by carnosine was reversed by alpha- fluoromethylhistidine, a selective and irreversible inhibitor of histidine decarboxylase (HDC). alpha-fluoromethylhistidine 44-72 histidine decarboxylase Rattus norvegicus 116-139 17169331-4 2007 The protection by carnosine was reversed by alpha- fluoromethylhistidine, a selective and irreversible inhibitor of histidine decarboxylase (HDC). alpha-fluoromethylhistidine 44-72 histidine decarboxylase Rattus norvegicus 141-144 17141473-5 2007 Furthermore, intracerebroventricular injection of alpha-fluoromethylhistidine (100 microg), a selective and irreversible histidine decarboxylase inhibitor, mimicked the attenuation of PSP induced by the lesion of TM E2-region. alpha-fluoromethylhistidine 50-77 histidine decarboxylase Rattus norvegicus 121-144 15662050-9 2005 Pretreatment with the irreversible inhibitor of histidine decarboxylase, alpha-fluoromethylhistidine, which is known to eliminate histamine from ECL cells, prevented the rise in microdialysate histamine. alpha-fluoromethylhistidine 73-100 histidine decarboxylase Rattus norvegicus 48-71 15179677-5 2004 H(3)receptor agonist, immepip, and histidine decarboxylase, alpha-fluoromethylhistidine reversed the ameliorating effect of clobenpropit on seizure development in a dose-dependent manner. alpha-fluoromethylhistidine 60-87 histidine decarboxylase Rattus norvegicus 35-58 11931695-5 2002 The inhibitory action of histidine was enhanced significantly by thioperamide (5 microg), however, was antagonized by both alpha fluoromethylhistidine (20 microg), a selective histidine decarboxylase inhibitor and H1 ant agonist pyrilamine (2, 5 mg/kg), dose-dependently and significantly. alpha-fluoromethylhistidine 123-150 histidine decarboxylase Rattus norvegicus 176-199 11788786-5 2002 Pretreatment of the rats with an ip bolus injection of alpha-fluoromethylhistidine, a suicide inhibitor of a histidine decarboxylase (HDC), at a dosage of 224 micromol/kg blocked the conversion of histidine into histamine and attenuated the suppressive effect of histidine on food intake from 64.2% to 88.1% of the controls (P < 0.05). alpha-fluoromethylhistidine 55-82 histidine decarboxylase Rattus norvegicus 109-132 11788786-5 2002 Pretreatment of the rats with an ip bolus injection of alpha-fluoromethylhistidine, a suicide inhibitor of a histidine decarboxylase (HDC), at a dosage of 224 micromol/kg blocked the conversion of histidine into histamine and attenuated the suppressive effect of histidine on food intake from 64.2% to 88.1% of the controls (P < 0.05). alpha-fluoromethylhistidine 55-82 histidine decarboxylase Rattus norvegicus 134-137 15084444-5 2004 alpha-Fluoromethylhistidine (FMH, 25 microg per site), a selective histidine decarboxylase inhibitor prevented the ameliorating effect of clobenpropit on the working memory deficits induced by MK-801. alpha-fluoromethylhistidine 0-27 histidine decarboxylase Rattus norvegicus 67-90 15084444-5 2004 alpha-Fluoromethylhistidine (FMH, 25 microg per site), a selective histidine decarboxylase inhibitor prevented the ameliorating effect of clobenpropit on the working memory deficits induced by MK-801. alpha-fluoromethylhistidine 29-32 histidine decarboxylase Rattus norvegicus 67-90 11557529-6 2001 Experiments employing specific histamine receptor agonists indicated that the inhibitory effect was not dependent on histamine production, and studies with the HDC inhibitor alpha-fluoromethylhistidine revealed that inhibition was unrelated to enzyme activity. alpha-fluoromethylhistidine 174-201 histidine decarboxylase Rattus norvegicus 160-163 10913579-3 2000 alpha-Fluoromethylhistidine, an irreversible inhibitor of the histamine-forming enzyme, histidine decarboxylase depletes ECL-cell but not mast-cell histamine. alpha-fluoromethylhistidine 0-27 histidine decarboxylase Rattus norvegicus 88-111 10913579-5 2000 Rats received alpha-fluoromethylhistidine by continuous subcutaneous infusion for 24 h. Maximally effective doses (>/=3 mg/kg/h) inhibited histidine decarboxylase and reduced oxyntic mucosal histamine in fed rats by 80-90%. alpha-fluoromethylhistidine 14-41 histidine decarboxylase Rattus norvegicus 142-165 9452148-2 1998 The depletion of neuronal histamine (HA) from the Me5 by the bilateral microinfusion of 448 nmol/rat alpha-fluoromethylhistidine (FMH), a specific suicide inhibitor of histidine decarboxylase, reduced the eating speed and prolonged meal duration, while leaving the meal size unaffected. alpha-fluoromethylhistidine 101-128 histidine decarboxylase Rattus norvegicus 168-191 10580415-7 1999 Systemic depletion of brain histamine levels by pretreatment with an intraperitoneal injection of 224 micromol/kg alpha-fluoromethylhistidine (FMH), a suicide inhibitor of HDC, attenuated the leptin-induced feeding suppression by 50.7% (P < 0.05). alpha-fluoromethylhistidine 114-141 histidine decarboxylase Rattus norvegicus 172-175 10580415-7 1999 Systemic depletion of brain histamine levels by pretreatment with an intraperitoneal injection of 224 micromol/kg alpha-fluoromethylhistidine (FMH), a suicide inhibitor of HDC, attenuated the leptin-induced feeding suppression by 50.7% (P < 0.05). alpha-fluoromethylhistidine 143-146 histidine decarboxylase Rattus norvegicus 172-175 10408253-9 1999 Excitatory effects of CCK-8S and gastrin-I were not modified by vagotomy or atropine, whereas cimetidine or alpha-fluoromethylhistidine (irreversible blocker of histidine decarboxylase) partly prevented acid hypersecretion induced by both peptides without affecting their pepsigogue effects. alpha-fluoromethylhistidine 108-135 histidine decarboxylase Rattus norvegicus 161-184 9452148-2 1998 The depletion of neuronal histamine (HA) from the Me5 by the bilateral microinfusion of 448 nmol/rat alpha-fluoromethylhistidine (FMH), a specific suicide inhibitor of histidine decarboxylase, reduced the eating speed and prolonged meal duration, while leaving the meal size unaffected. alpha-fluoromethylhistidine 130-133 histidine decarboxylase Rattus norvegicus 168-191 8653552-3 1995 Depletion of neuronal histamine in the hypothalamus induced by alpha-fluoromethylhistidine, a suicide inhibitor of the histamine synthesizing enzyme histidine decarboxylase (HDC), attenuated the suppressive effect of IL-1 beta on food intake, facilitated the inhibitory effect on water intake, and enhanced its thermogenic effect. alpha-fluoromethylhistidine 63-90 histidine decarboxylase Rattus norvegicus 149-172 9515556-1 1998 We examined the effects of repeated administration of (S)-alpha-fluoromethylhistidine (FMH), a specific inhibitor of histidine decarboxylase (HDC), on radial maze performance and brain contents of histamine and amino acids in rats. alpha-fluoromethylhistidine 54-85 histidine decarboxylase Rattus norvegicus 117-140 9515556-1 1998 We examined the effects of repeated administration of (S)-alpha-fluoromethylhistidine (FMH), a specific inhibitor of histidine decarboxylase (HDC), on radial maze performance and brain contents of histamine and amino acids in rats. alpha-fluoromethylhistidine 54-85 histidine decarboxylase Rattus norvegicus 142-145 9515556-1 1998 We examined the effects of repeated administration of (S)-alpha-fluoromethylhistidine (FMH), a specific inhibitor of histidine decarboxylase (HDC), on radial maze performance and brain contents of histamine and amino acids in rats. alpha-fluoromethylhistidine 87-90 histidine decarboxylase Rattus norvegicus 117-140 9515556-1 1998 We examined the effects of repeated administration of (S)-alpha-fluoromethylhistidine (FMH), a specific inhibitor of histidine decarboxylase (HDC), on radial maze performance and brain contents of histamine and amino acids in rats. alpha-fluoromethylhistidine 87-90 histidine decarboxylase Rattus norvegicus 142-145 8898415-2 1996 We have studied how histamine depletion by subcutaneous infusion of the HDC inhibitor alpha-fluoromethyl-histidine (alpha-FMH) affects how ECL cells respond to hypergastrinemia in terms of HDC and CGA mRNA levels. alpha-fluoromethylhistidine 86-114 histidine decarboxylase Rattus norvegicus 72-75 8898415-2 1996 We have studied how histamine depletion by subcutaneous infusion of the HDC inhibitor alpha-fluoromethyl-histidine (alpha-FMH) affects how ECL cells respond to hypergastrinemia in terms of HDC and CGA mRNA levels. alpha-fluoromethylhistidine 86-114 histidine decarboxylase Rattus norvegicus 189-192 8898415-2 1996 We have studied how histamine depletion by subcutaneous infusion of the HDC inhibitor alpha-fluoromethyl-histidine (alpha-FMH) affects how ECL cells respond to hypergastrinemia in terms of HDC and CGA mRNA levels. alpha-fluoromethylhistidine 116-125 histidine decarboxylase Rattus norvegicus 72-75 8898415-5 1996 RESULTS: alpha-FMH for 24 h increased the HDC and CGA mRNA levels without increasing the serum gastrin concentration. alpha-fluoromethylhistidine 9-18 histidine decarboxylase Rattus norvegicus 42-45 8898415-8 1996 HDC mRNA levels were higher after alpha-FMH + omeprazole than after omeprazole alone. alpha-fluoromethylhistidine 34-43 histidine decarboxylase Rattus norvegicus 0-3 8898415-9 1996 alpha-FMH alone induced an HDC mRNA level that was similar in magnitude to that observed after omeprazole, although the serum gastrin concentration after alpha-FMH was much lower. alpha-fluoromethylhistidine 0-9 histidine decarboxylase Rattus norvegicus 27-30 8898415-10 1996 In antrectomized rats alpha-FMH increased the HDC and CGA mRNA levels without increasing the serum gastrin concentration. alpha-fluoromethylhistidine 22-31 histidine decarboxylase Rattus norvegicus 46-49 9098789-0 1997 alpha-Fluoromethylhistidine elevates histidine decarboxylase mRNA and chromogranin A mRNA levels in rat oxyntic mucosa. alpha-fluoromethylhistidine 0-27 histidine decarboxylase Rattus norvegicus 37-60 8929340-5 1996 alpha-Fluoromethylhistidine is an irreversible inhibitor of histidine decarboxylase, the histamine-forming enzyme. alpha-fluoromethylhistidine 0-27 histidine decarboxylase Rattus norvegicus 60-83 8938662-1 1996 In this study we assessed the cardiovascular response to 13 days of irreversible inhibition of the enzyme histidine-decarboxylase (HD) with alpha-fluoro-methylhistidine (AFMH). alpha-fluoromethylhistidine 140-168 histidine decarboxylase Rattus norvegicus 106-129 8938662-1 1996 In this study we assessed the cardiovascular response to 13 days of irreversible inhibition of the enzyme histidine-decarboxylase (HD) with alpha-fluoro-methylhistidine (AFMH). alpha-fluoromethylhistidine 170-174 histidine decarboxylase Rattus norvegicus 106-129 8594930-3 1995 However, depletion of neuronal histamine induced by intraperitoneal injection of 160 mumol/rat alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase (HDC), attenuated the suppressive effect of IL-1 beta on food intake, facilitated the suppressive effect on drinking, and enhanced the elevating effect on rectal temperature. alpha-fluoromethylhistidine 95-122 histidine decarboxylase Rattus norvegicus 147-170 8594930-3 1995 However, depletion of neuronal histamine induced by intraperitoneal injection of 160 mumol/rat alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase (HDC), attenuated the suppressive effect of IL-1 beta on food intake, facilitated the suppressive effect on drinking, and enhanced the elevating effect on rectal temperature. alpha-fluoromethylhistidine 95-122 histidine decarboxylase Rattus norvegicus 172-175 8653552-3 1995 Depletion of neuronal histamine in the hypothalamus induced by alpha-fluoromethylhistidine, a suicide inhibitor of the histamine synthesizing enzyme histidine decarboxylase (HDC), attenuated the suppressive effect of IL-1 beta on food intake, facilitated the inhibitory effect on water intake, and enhanced its thermogenic effect. alpha-fluoromethylhistidine 63-90 histidine decarboxylase Rattus norvegicus 174-177 7542315-7 1995 Next, the effects of (S) alpha-fluoromethylhistidine (FMH), a specific inhibitor of HDC, on the histamine contents and HDC activities of various regions of the brain were examined in Ws/Ws rats. alpha-fluoromethylhistidine 54-57 histidine decarboxylase Rattus norvegicus 119-122 7586491-9 1995 Administration of (S) alpha-fluoromethylhistidine (FMH), a specific inhibitor of L-histidine decarboxylase (HDC), significantly decreased both the HDC activity and histamine concentration during postnatal development. alpha-fluoromethylhistidine 22-49 histidine decarboxylase Rattus norvegicus 81-106 7586491-9 1995 Administration of (S) alpha-fluoromethylhistidine (FMH), a specific inhibitor of L-histidine decarboxylase (HDC), significantly decreased both the HDC activity and histamine concentration during postnatal development. alpha-fluoromethylhistidine 22-49 histidine decarboxylase Rattus norvegicus 108-111 7586491-9 1995 Administration of (S) alpha-fluoromethylhistidine (FMH), a specific inhibitor of L-histidine decarboxylase (HDC), significantly decreased both the HDC activity and histamine concentration during postnatal development. alpha-fluoromethylhistidine 22-49 histidine decarboxylase Rattus norvegicus 147-150 7586491-9 1995 Administration of (S) alpha-fluoromethylhistidine (FMH), a specific inhibitor of L-histidine decarboxylase (HDC), significantly decreased both the HDC activity and histamine concentration during postnatal development. alpha-fluoromethylhistidine 51-54 histidine decarboxylase Rattus norvegicus 81-106 7586491-9 1995 Administration of (S) alpha-fluoromethylhistidine (FMH), a specific inhibitor of L-histidine decarboxylase (HDC), significantly decreased both the HDC activity and histamine concentration during postnatal development. alpha-fluoromethylhistidine 51-54 histidine decarboxylase Rattus norvegicus 108-111 7586491-9 1995 Administration of (S) alpha-fluoromethylhistidine (FMH), a specific inhibitor of L-histidine decarboxylase (HDC), significantly decreased both the HDC activity and histamine concentration during postnatal development. alpha-fluoromethylhistidine 51-54 histidine decarboxylase Rattus norvegicus 147-150 7720668-6 1995 Pretreatment with the HA synthesis inhibitor alpha-fluoromethylhistidine (alpha FMH) increased the expression of HDC mRNA in 24-h dehydrated rats, but had no effect in euhydrated rats. alpha-fluoromethylhistidine 45-72 histidine decarboxylase Rattus norvegicus 113-116 7720668-6 1995 Pretreatment with the HA synthesis inhibitor alpha-fluoromethylhistidine (alpha FMH) increased the expression of HDC mRNA in 24-h dehydrated rats, but had no effect in euhydrated rats. alpha-fluoromethylhistidine 74-83 histidine decarboxylase Rattus norvegicus 113-116 7536939-3 1995 We examined the effect of alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase, on ornithine decarboxylase activity after ischemia-reperfusion and compared this with its effect on the rat after refeeding. alpha-fluoromethylhistidine 26-53 histidine decarboxylase Rattus norvegicus 78-101 7720459-6 1995 The increase of ornithine decarboxylase activity was attenuated when the increase of histamine synthesis was suppressed by the inhibition of histidine decarboxylase activity caused by pretreatment with alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase. alpha-fluoromethylhistidine 202-229 histidine decarboxylase Rattus norvegicus 141-164 7720459-6 1995 The increase of ornithine decarboxylase activity was attenuated when the increase of histamine synthesis was suppressed by the inhibition of histidine decarboxylase activity caused by pretreatment with alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase. alpha-fluoromethylhistidine 202-229 histidine decarboxylase Rattus norvegicus 254-277 8156416-1 1994 Intraperitoneal injection of alpha-fluoromethylhistidine (alpha-FMH; 200 mg/kg), a specific inhibitor of histidine decarboxylase produced a severe depletion of neocortical and hippocampal histamine 3 h later as determined by a radioenzymatic assay. alpha-fluoromethylhistidine 29-56 histidine decarboxylase Rattus norvegicus 105-128 8156416-1 1994 Intraperitoneal injection of alpha-fluoromethylhistidine (alpha-FMH; 200 mg/kg), a specific inhibitor of histidine decarboxylase produced a severe depletion of neocortical and hippocampal histamine 3 h later as determined by a radioenzymatic assay. alpha-fluoromethylhistidine 58-67 histidine decarboxylase Rattus norvegicus 105-128 8415942-5 1993 However, obese Zuckers and histamine depleted rats due to alpha-fluoromethyl-histidine (FMH), a specific "suicide" inhibitor of a histamine synthesizing decarboxylase enzyme (HDC), failed to show this decrease in food intake as adaptive behavior. alpha-fluoromethylhistidine 88-91 histidine decarboxylase Rattus norvegicus 175-178 8313152-2 1993 Infusion of alpha-fluoromethylhistidine (FMH), a "suicide" inhibitor of histidine decarboxylase (HDC), into the third cerebroventricle induced feeding in the early light phase when the histamine synthesis was most accelerated. alpha-fluoromethylhistidine 12-39 histidine decarboxylase Rattus norvegicus 72-95 8313152-2 1993 Infusion of alpha-fluoromethylhistidine (FMH), a "suicide" inhibitor of histidine decarboxylase (HDC), into the third cerebroventricle induced feeding in the early light phase when the histamine synthesis was most accelerated. alpha-fluoromethylhistidine 12-39 histidine decarboxylase Rattus norvegicus 97-100 8313152-2 1993 Infusion of alpha-fluoromethylhistidine (FMH), a "suicide" inhibitor of histidine decarboxylase (HDC), into the third cerebroventricle induced feeding in the early light phase when the histamine synthesis was most accelerated. alpha-fluoromethylhistidine 41-44 histidine decarboxylase Rattus norvegicus 72-95 8313152-2 1993 Infusion of alpha-fluoromethylhistidine (FMH), a "suicide" inhibitor of histidine decarboxylase (HDC), into the third cerebroventricle induced feeding in the early light phase when the histamine synthesis was most accelerated. alpha-fluoromethylhistidine 41-44 histidine decarboxylase Rattus norvegicus 97-100 8304983-0 1994 alpha-Fluoromethylhistidine-induced inhibition of brain histidine decarboxylase. alpha-fluoromethylhistidine 0-27 histidine decarboxylase Rattus norvegicus 56-79 8304983-2 1994 The actions of S-alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of the histamine biosynthetic enzyme histidine decarboxylase (HD), were studied on rat brain HD, as measured by a recently developed CO2-trapping enzymatic method. alpha-fluoromethylhistidine 15-44 histidine decarboxylase Rattus norvegicus 115-138 8304983-2 1994 The actions of S-alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of the histamine biosynthetic enzyme histidine decarboxylase (HD), were studied on rat brain HD, as measured by a recently developed CO2-trapping enzymatic method. alpha-fluoromethylhistidine 46-49 histidine decarboxylase Rattus norvegicus 115-138 7907523-5 1993 of alpha-fluoromethylhistidine (FMH), a specific inhibitor of the HA synthesizing enzyme histidine decarboxylase (HDC), abolished feeding suppression completely. alpha-fluoromethylhistidine 3-30 histidine decarboxylase Rattus norvegicus 89-112 7907523-5 1993 of alpha-fluoromethylhistidine (FMH), a specific inhibitor of the HA synthesizing enzyme histidine decarboxylase (HDC), abolished feeding suppression completely. alpha-fluoromethylhistidine 3-30 histidine decarboxylase Rattus norvegicus 114-117 7907523-5 1993 of alpha-fluoromethylhistidine (FMH), a specific inhibitor of the HA synthesizing enzyme histidine decarboxylase (HDC), abolished feeding suppression completely. alpha-fluoromethylhistidine 32-35 histidine decarboxylase Rattus norvegicus 89-112 7907523-5 1993 of alpha-fluoromethylhistidine (FMH), a specific inhibitor of the HA synthesizing enzyme histidine decarboxylase (HDC), abolished feeding suppression completely. alpha-fluoromethylhistidine 32-35 histidine decarboxylase Rattus norvegicus 114-117 1729265-5 1992 These increases in HDC activity, and mucosal and lymph histamine levels were suppressed by pretreatment of alpha-fluoromethylhistidine (alpha-FMH), a suicide inhibitor of HDC. alpha-fluoromethylhistidine 107-134 histidine decarboxylase Rattus norvegicus 19-22 1341077-8 1992 Recently, we could show that alpha-fluoromethylhistidine, which is a suicide inhibitor of histidine decarboxylase, effectively depletes the ECL cells of histamine and that the histamine-depleted ECL cells respond to gastrin with hyperplasia in a manner identical to normal ECL cells. alpha-fluoromethylhistidine 29-56 histidine decarboxylase Rattus norvegicus 90-113 1384983-5 1992 Histamine synthesis was inhibited with alpha-fluoromethylhistidine (3 mg.kg-1.h-1) given via osmotic minipumps over a period of 24 h. The treatment reduced the histidine decarboxylase activity (approximately 20% remaining) and histamine concentration (less than 20% remaining) in the oxyntic mucosa, as well as the intensity of histamine- and chromogranin A-immunostaining in the ECL cells, compared to control rats. alpha-fluoromethylhistidine 39-66 histidine decarboxylase Rattus norvegicus 160-183 1499940-7 1992 Treatment with alpha-fluoromethylhistidine plus omeprazole markedly reduced the histidine decarboxylase activity and histamine concentration, but the weight of the stomach and oxyntic mucosa, the enterochromaffinlike cell density, and intensity of histidine decarboxylase immunostaining were increased to at least the same extent as after omeprazole alone. alpha-fluoromethylhistidine 15-42 histidine decarboxylase Rattus norvegicus 80-103 1499940-7 1992 Treatment with alpha-fluoromethylhistidine plus omeprazole markedly reduced the histidine decarboxylase activity and histamine concentration, but the weight of the stomach and oxyntic mucosa, the enterochromaffinlike cell density, and intensity of histidine decarboxylase immunostaining were increased to at least the same extent as after omeprazole alone. alpha-fluoromethylhistidine 15-42 histidine decarboxylase Rattus norvegicus 248-271 1559640-8 1992 alpha-Fluoromethylhistidine, a specific inhibitor of HDC, is a powerful tool for reducing the neuronal histamine in the brain. alpha-fluoromethylhistidine 0-27 histidine decarboxylase Rattus norvegicus 53-56 1729265-5 1992 These increases in HDC activity, and mucosal and lymph histamine levels were suppressed by pretreatment of alpha-fluoromethylhistidine (alpha-FMH), a suicide inhibitor of HDC. alpha-fluoromethylhistidine 107-134 histidine decarboxylase Rattus norvegicus 171-174 1729265-5 1992 These increases in HDC activity, and mucosal and lymph histamine levels were suppressed by pretreatment of alpha-fluoromethylhistidine (alpha-FMH), a suicide inhibitor of HDC. alpha-fluoromethylhistidine 136-145 histidine decarboxylase Rattus norvegicus 19-22 1729265-5 1992 These increases in HDC activity, and mucosal and lymph histamine levels were suppressed by pretreatment of alpha-fluoromethylhistidine (alpha-FMH), a suicide inhibitor of HDC. alpha-fluoromethylhistidine 136-145 histidine decarboxylase Rattus norvegicus 171-174 1907141-5 1991 S-alpha-Fluoromethylhistidine (FMH) and alpha-hydrazinohistidine, specific inhibitors of HDC, induced concentration-dependent reductions of enzyme activity by up to 90%, whereas inhibitors of other decarboxylases had little or no effect. alpha-fluoromethylhistidine 0-29 histidine decarboxylase Rattus norvegicus 89-92 1907141-5 1991 S-alpha-Fluoromethylhistidine (FMH) and alpha-hydrazinohistidine, specific inhibitors of HDC, induced concentration-dependent reductions of enzyme activity by up to 90%, whereas inhibitors of other decarboxylases had little or no effect. alpha-fluoromethylhistidine 31-34 histidine decarboxylase Rattus norvegicus 89-92 2210091-2 1990 This was done by examining the effects of inhibition of the histamine-producing enzyme histidine decarboxylase (HDC) with alpha-fluoromethylhistidine (alpha-FMH) and the effects of degranulation of the mucosal mast cells with dexamethasone. alpha-fluoromethylhistidine 122-149 histidine decarboxylase Rattus norvegicus 87-110 1897430-0 1991 Histidine decarboxylase inhibition induced by alpha-fluoromethylhistidine provokes learning-related hypokinetic activity. alpha-fluoromethylhistidine 46-73 histidine decarboxylase Rattus norvegicus 0-23 1865929-2 1991 We investigated the effect of inhibition of histamine synthesis by alpha-fluoromethylhistidine (alpha-FMH), the irreversible inhibitor of histidine decarboxylase, on the development and maintenance of hypertension in spontaneously hypertensive rats. alpha-fluoromethylhistidine 96-105 histidine decarboxylase Rattus norvegicus 138-161 1865929-4 1991 Treatment of spontaneously hypertensive rats and normotensive Wistar-Kyoto rats with alpha-fluoromethylhistidine led to a pronounced decrease in the histidine decarboxylase activity and in the histamine concentration in the brain (hypothalamus, brainstem, cortex-midbrain). alpha-fluoromethylhistidine 85-112 histidine decarboxylase Rattus norvegicus 149-172 2053511-4 1991 Some functions, including the circadian rhythms, sleep-arousal cycles, drinking, feeding, thermoregulation, and neuroendocrine controls which were elucidated by administration of alpha-fluoromethylhistidine, a suicide substrate for histidine decarboxylase, are discussed here, although the true functions are still under investigations. alpha-fluoromethylhistidine 179-206 histidine decarboxylase Rattus norvegicus 232-255 2210091-2 1990 This was done by examining the effects of inhibition of the histamine-producing enzyme histidine decarboxylase (HDC) with alpha-fluoromethylhistidine (alpha-FMH) and the effects of degranulation of the mucosal mast cells with dexamethasone. alpha-fluoromethylhistidine 122-149 histidine decarboxylase Rattus norvegicus 112-115 2210091-2 1990 This was done by examining the effects of inhibition of the histamine-producing enzyme histidine decarboxylase (HDC) with alpha-fluoromethylhistidine (alpha-FMH) and the effects of degranulation of the mucosal mast cells with dexamethasone. alpha-fluoromethylhistidine 151-160 histidine decarboxylase Rattus norvegicus 87-110 2210091-2 1990 This was done by examining the effects of inhibition of the histamine-producing enzyme histidine decarboxylase (HDC) with alpha-fluoromethylhistidine (alpha-FMH) and the effects of degranulation of the mucosal mast cells with dexamethasone. alpha-fluoromethylhistidine 151-160 histidine decarboxylase Rattus norvegicus 112-115 2325822-5 1990 The partially purified histidine decarboxylase from both sources was dependent on pyridoxal phosphate for maximal activity and was inhibited by alpha-fluoromethylhistidine, nickel chloride and cobaltous chloride but was not inhibited by impromidine, alpha-methyldopa, DTNB, zinc chloride or mercuric chloride. alpha-fluoromethylhistidine 144-171 histidine decarboxylase Rattus norvegicus 23-46 2464390-3 1988 The K+-evoked release of [3H]-histamine was attenuated by incubation in calcium-free medium and prevented by prior incubation of brain slices with the selective histidine decarboxylase inhibitor S-(alpha)-fluoromethylhistidine. alpha-fluoromethylhistidine 195-226 histidine decarboxylase Rattus norvegicus 161-184 2615053-2 1989 ), a specific inhibitor of histidine decarboxylase, on the presumption that alpha-FMH depletable HA pools represent neuronal ones. alpha-fluoromethylhistidine 76-85 histidine decarboxylase Rattus norvegicus 27-50 2750595-2 1989 Although pre-exposure to alpha-fluoromethyl histidine (FMH), an inhibitor of histidine decarboxylase, prevented the effect of AD in vivo and in vitro, this compound was also found to inhibit mast cell granule swelling evoked by AD, a response linked to histamine changes. alpha-fluoromethylhistidine 25-53 histidine decarboxylase Rattus norvegicus 77-100 2750595-2 1989 Although pre-exposure to alpha-fluoromethyl histidine (FMH), an inhibitor of histidine decarboxylase, prevented the effect of AD in vivo and in vitro, this compound was also found to inhibit mast cell granule swelling evoked by AD, a response linked to histamine changes. alpha-fluoromethylhistidine 55-58 histidine decarboxylase Rattus norvegicus 77-100 3035409-9 1987 When alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase, was administered at doses of 100 mg/kg/day (i.p. alpha-fluoromethylhistidine 34-37 histidine decarboxylase Rattus norvegicus 69-92 3685079-1 1987 We examined the ability of two specific inhibitors of histidine decarboxylase, (s)-alpha-fluoromethylhistidine (FMHd) and (s)-alpha-fluoromethylhistamine (FMHm), to inhibit basal gastric acid secretion. alpha-fluoromethylhistidine 79-110 histidine decarboxylase Rattus norvegicus 54-77 3685079-1 1987 We examined the ability of two specific inhibitors of histidine decarboxylase, (s)-alpha-fluoromethylhistidine (FMHd) and (s)-alpha-fluoromethylhistamine (FMHm), to inhibit basal gastric acid secretion. alpha-fluoromethylhistidine 112-116 histidine decarboxylase Rattus norvegicus 54-77 4058657-7 1985 Alpha-fluoromethylhistidine inhibited histidine decarboxylase activity almost totally in vitro at 10 microM and about 80% in vivo after six days of infusion (100 mg/kg/day) in all brain regions except the cerebellum. alpha-fluoromethylhistidine 0-27 histidine decarboxylase Rattus norvegicus 38-61 2420333-12 1986 Both release of endogenous histamine and formation of radiolabeled histamine from labeled histidine were inhibited by the histidine decarboxylase inhibitor alpha-fluoromethylhistidine (10 microM). alpha-fluoromethylhistidine 156-183 histidine decarboxylase Rattus norvegicus 122-145 4050131-8 1985 Pretreatment with alpha-fluoromethylhistidine (alpha FMH), a potent and specific inhibitor of histidine decarboxylase, produced a reduction in the effects of histidine. alpha-fluoromethylhistidine 18-45 histidine decarboxylase Rattus norvegicus 94-117 4050131-8 1985 Pretreatment with alpha-fluoromethylhistidine (alpha FMH), a potent and specific inhibitor of histidine decarboxylase, produced a reduction in the effects of histidine. alpha-fluoromethylhistidine 47-56 histidine decarboxylase Rattus norvegicus 94-117 4011742-1 1985 Effects of alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase, on the sleep-waking parameters were studied in rats for 24 hours. alpha-fluoromethylhistidine 40-43 histidine decarboxylase Rattus norvegicus 75-98 6208052-2 1984 Histamine catabolism inhibitors do not reproduce this effect; cells pre-incubated with alpha-fluoromethylhistidine are unresponsive to compound 48/80 which therefore activates pre-formed histidine decarboxylase rather than "inducing" it. alpha-fluoromethylhistidine 87-114 histidine decarboxylase Rattus norvegicus 187-210 6712729-1 1984 The mechanism of inactivation by (S)-alpha-fluoromethylhistidine (FMH) of L-histidine decarboxylase (HDC, L-histidine carboxy-lyase, EC 4.1.1.22) purified from whole bodies of fetal rats was studied. alpha-fluoromethylhistidine 33-64 histidine decarboxylase Rattus norvegicus 74-99 6712729-1 1984 The mechanism of inactivation by (S)-alpha-fluoromethylhistidine (FMH) of L-histidine decarboxylase (HDC, L-histidine carboxy-lyase, EC 4.1.1.22) purified from whole bodies of fetal rats was studied. alpha-fluoromethylhistidine 33-64 histidine decarboxylase Rattus norvegicus 101-104 6712729-1 1984 The mechanism of inactivation by (S)-alpha-fluoromethylhistidine (FMH) of L-histidine decarboxylase (HDC, L-histidine carboxy-lyase, EC 4.1.1.22) purified from whole bodies of fetal rats was studied. alpha-fluoromethylhistidine 66-69 histidine decarboxylase Rattus norvegicus 74-99 6712729-1 1984 The mechanism of inactivation by (S)-alpha-fluoromethylhistidine (FMH) of L-histidine decarboxylase (HDC, L-histidine carboxy-lyase, EC 4.1.1.22) purified from whole bodies of fetal rats was studied. alpha-fluoromethylhistidine 66-69 histidine decarboxylase Rattus norvegicus 101-104 6855476-0 1983 Effects of alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase, on development of brain histamine and catecholamine systems in the neonatal rat. alpha-fluoromethylhistidine 11-38 histidine decarboxylase Rattus norvegicus 75-98 6645794-0 1983 Developmental effects of alpha-fluoromethylhistidine, an irreversible inhibitor of histidine decarboxylase, on growth and on levels and turnover of catecholamines. alpha-fluoromethylhistidine 25-52 histidine decarboxylase Rattus norvegicus 83-106 6645794-1 1983 To examine the potential participation of histamine in cellular development, neonatal rats were given daily 50 mg/kg doses of alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase; previous studies have shown this regimen to deplete both neurotransmitter and nonneurotransmitter pools of histamine. alpha-fluoromethylhistidine 126-153 histidine decarboxylase Rattus norvegicus 190-213 6645794-1 1983 To examine the potential participation of histamine in cellular development, neonatal rats were given daily 50 mg/kg doses of alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase; previous studies have shown this regimen to deplete both neurotransmitter and nonneurotransmitter pools of histamine. alpha-fluoromethylhistidine 155-158 histidine decarboxylase Rattus norvegicus 190-213 6135617-3 1983 alpha-Fluoromethyl histidine inhibited the increase of histidine decarboxylase activity in the gastric mucosa, inhibited the rise of hypothalamic histamine content and decreased the incidence of gastric lesions to the same extent as did cimetidine. alpha-fluoromethylhistidine 0-28 histidine decarboxylase Rattus norvegicus 55-78 6860344-2 1983 alpha-Fluoromethyl histidine is an irreversible inhibitor of histidine decarboxylase. alpha-fluoromethylhistidine 0-28 histidine decarboxylase Rattus norvegicus 61-84 6830620-1 1983 Effect of inhibition of histidine decarboxylase by alpha-fluoromethylhistidine. alpha-fluoromethylhistidine 51-78 histidine decarboxylase Rattus norvegicus 24-47 6830620-2 1983 Preincubation with (S)-alpha-fluoromethylhistidine, an irreversible inhibitor of histidine decarboxylase, was found to markedly reduce, but not eliminate, the uptake of [3H]histidine by rat peritoneal mast cells. alpha-fluoromethylhistidine 19-50 histidine decarboxylase Rattus norvegicus 81-104 6855476-0 1983 Effects of alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase, on development of brain histamine and catecholamine systems in the neonatal rat. alpha-fluoromethylhistidine 40-43 histidine decarboxylase Rattus norvegicus 75-98 6855476-1 1983 Daily administration of FMH to neonatal rats produced long-lasting inhibition of histidine decarboxylase in hypothalamus and cerebral cortex and led to depletion of histamine in both brain regions. alpha-fluoromethylhistidine 24-27 histidine decarboxylase Rattus norvegicus 81-104 27342775-6 2016 Histidine decarboxylase (HDC) enzyme inhibitor alpha-fluoromethylhistidine was administered intracerebroventricularly (i.c.v.). alpha-fluoromethylhistidine 47-74 histidine decarboxylase Rattus norvegicus 0-23 33390452-6 2021 alpha-Fluoromethylhistidine, an histidine decarboxylase inhibitor, also inhibited active avoidance response. alpha-fluoromethylhistidine 0-27 histidine decarboxylase Rattus norvegicus 32-55 27342775-6 2016 Histidine decarboxylase (HDC) enzyme inhibitor alpha-fluoromethylhistidine was administered intracerebroventricularly (i.c.v.). alpha-fluoromethylhistidine 47-74 histidine decarboxylase Rattus norvegicus 25-28