PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12371609-4 2002 The significance of in situ generated histamine was shown on colony formation by inhibitory action of alphaFMH (blocking HDC activity, i.e. de novo histamine formation) and by N,N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine-HCl (DPPE) disturbing the interference of histamine with intracellular binding sites. alpha-fluoromethylhistidine 102-110 histidine decarboxylase Homo sapiens 121-124 12972479-7 2003 The addition of alpha-fluoromethylhistidine, a specific inhibitor of histidine decarboxylase (the enzyme responsible for histamine production), reduced the rate of proliferation of HAC. alpha-fluoromethylhistidine 16-43 histidine decarboxylase Homo sapiens 69-92 11246041-6 2001 Depletion of histamine by alpha-fluoromethylhistidine (an irreversible inhibitor of HDC) prevents gastrin-induced but not histamine-induced gastric acid secretion. alpha-fluoromethylhistidine 26-53 histidine decarboxylase Homo sapiens 84-87 12469348-4 2002 (S)-alpha-fluoromethylhistidine, a specific and potent irreversible inhibitor of HDC, was also very useful in studies on functions of the neuron system. alpha-fluoromethylhistidine 0-31 histidine decarboxylase Homo sapiens 81-84 2774643-1 1989 Alpha-fluoromethylhistidine (alpha-FMH), a new irreversible inhibitor of mammalian histidine decarboxylase, was tested in the treatment of idiopathic cold urticaria in 11 patients. alpha-fluoromethylhistidine 0-27 histidine decarboxylase Homo sapiens 83-106 9654597-5 1998 By inhibiting the HDC enzyme activity by FMH and blocking the intracellular action of histamine by DPPE, a significant decrease in cell proliferation was observed in mitogen stimulated lymphocytes of healthy donors. alpha-fluoromethylhistidine 41-44 histidine decarboxylase Homo sapiens 18-21 2117926-5 1990 The enzyme was inhibited by alpha-fluoromethylhistidine but not by carbidopa, was unable to form dopamine from L-3,4-dihydroxyphenylalanine, and had a Km value for histidine of 0.27 mM, indicating that it was HDC and not aromatic amino acid decarboxylase. alpha-fluoromethylhistidine 28-55 histidine decarboxylase Homo sapiens 209-212 2182624-2 1990 Mechanism-based inactivation of pyridoxal phosphate-dependent histidine decarboxylase by (S)-alpha-(fluoromethyl)histidine was studied. alpha-fluoromethylhistidine 89-122 histidine decarboxylase Homo sapiens 62-85 1834679-4 1991 We further provide evidence that this phenomenon is completely abolished: i) by preventing GM-CSF-induced histamine synthesis by alpha-FMH, the specific inhibitor of histidine decarboxylase (HDC), or ii) by blocking the binding sites of H2 histamine receptors with their specific antagonist oxmetidine. alpha-fluoromethylhistidine 129-138 histidine decarboxylase Homo sapiens 166-189 1834679-4 1991 We further provide evidence that this phenomenon is completely abolished: i) by preventing GM-CSF-induced histamine synthesis by alpha-FMH, the specific inhibitor of histidine decarboxylase (HDC), or ii) by blocking the binding sites of H2 histamine receptors with their specific antagonist oxmetidine. alpha-fluoromethylhistidine 129-138 histidine decarboxylase Homo sapiens 191-194 2238092-0 1990 Pharmacology of alpha-fluoromethylhistidine, a specific inhibitor of histidine decarboxylase. alpha-fluoromethylhistidine 16-43 histidine decarboxylase Homo sapiens 69-92 2238092-1 1990 alpha-Fluoromethyl-[S]-histidine (FMH) is a specific and potent inhibitor of histidine decarboxylase, which forms histamine from histidine. alpha-fluoromethylhistidine 34-37 histidine decarboxylase Homo sapiens 77-100 2774643-1 1989 Alpha-fluoromethylhistidine (alpha-FMH), a new irreversible inhibitor of mammalian histidine decarboxylase, was tested in the treatment of idiopathic cold urticaria in 11 patients. alpha-fluoromethylhistidine 29-38 histidine decarboxylase Homo sapiens 83-106 4052095-0 1985 In vivo and in vitro inhibition of human histidine decarboxylase by (S)-alpha-fluoromethylhistidine. alpha-fluoromethylhistidine 68-99 histidine decarboxylase Homo sapiens 41-64 4052095-2 1985 HDC activity was inhibited in vitro to more than 90% by (S)-alpha-fluoromethylhistidine (alpha-FMH) at concentrations of 10(-5) M and above. alpha-fluoromethylhistidine 56-87 histidine decarboxylase Homo sapiens 0-3 4052095-2 1985 HDC activity was inhibited in vitro to more than 90% by (S)-alpha-fluoromethylhistidine (alpha-FMH) at concentrations of 10(-5) M and above. alpha-fluoromethylhistidine 89-98 histidine decarboxylase Homo sapiens 0-3 4052095-5 1985 A dose-dependent inhibition of HDC activity was observed in PBL that were isolated both at 12 hr after administration of the first dose of alpha-FMH and after treatment for 1 week. alpha-fluoromethylhistidine 139-148 histidine decarboxylase Homo sapiens 31-34 4052095-6 1985 At the 50 and 100 mg doses of alpha-FMH, there was complete inhibition of HDC activity and partial inhibition at the 10 mg dose. alpha-fluoromethylhistidine 30-39 histidine decarboxylase Homo sapiens 74-77 4052095-7 1985 Twenty-four hours after the last dose, HDC activity had recovered to 64-100%, 44-46%, and 30-52% of control values in subjects that received 10, 50 and 100 mg alpha-FMH respectively. alpha-fluoromethylhistidine 159-168 histidine decarboxylase Homo sapiens 39-42 3994743-1 1985 An irreversible inhibitor of histidine decarboxylase, alpha-fluoromethylhistidine (FMH), was used to inhibit histamine formation by mast cells in vivo. alpha-fluoromethylhistidine 54-81 histidine decarboxylase Homo sapiens 29-52 3994743-1 1985 An irreversible inhibitor of histidine decarboxylase, alpha-fluoromethylhistidine (FMH), was used to inhibit histamine formation by mast cells in vivo. alpha-fluoromethylhistidine 83-86 histidine decarboxylase Homo sapiens 29-52 6712729-0 1984 Mechanism of inactivation of mammalian L-histidine decarboxylase by (S)-alpha-fluoromethylhistidine. alpha-fluoromethylhistidine 68-99 histidine decarboxylase Homo sapiens 39-64 28228363-3 2017 (S)-alpha-Fluoromethylhistidine di-hydrochloride (alpha-FMH) is a potent HDC inhibitor that is commercially available at high cost in small amounts only. alpha-fluoromethylhistidine 50-59 histidine decarboxylase Homo sapiens 73-76 6641910-1 1983 In rats, chronic infusion of alpha-fluoromethyl histidine, a selective irreversible inhibitor of mammalian histidine decarboxylase, caused a marked depletion of histamine in all tissues examined. alpha-fluoromethylhistidine 29-57 histidine decarboxylase Homo sapiens 107-130