PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
430377-2	1979	A progressive and pronounced negative inotropic effect was observed with low to intermediate ryanodine concentrations (5 nM-1 muM) while a rebound or reversal of these initial changes back toward pre-drug values was obtained as the ryanodine concentration was further increased to 100 muM.	Ryanodine	93-102	latexin	Homo sapiens	126-129	
430377-6	1979	The response to a single addition of 100 muM ryanodine, in the presence of 2.5 mM Ca++ mimicked both the qualitative and quantitative aspects of the cumulative concentration response curve.	Ryanodine	45-54	latexin	Homo sapiens	41-44	
430377-9	1979	Ryanodine (1 muM; 2.5 mM Ca++) abolished the normal increase in dF/dt following either paired electrical stimulation (PES) or 50 mOsM mannitol, but not that in response to a doubling of the stimulation rate (0.2--0.4 Hz).	Ryanodine	0-9	latexin	Homo sapiens	13-16	
430377-13	1979	In the presence of high concentrations of both ryanodine (100 muM) and calcium (5 mM) both the transient and steady-state responses to a doubling of the stimulation rate (0.2--0.4 Hz) were markedly depressed, whereas the decrease in DF or dF/dt normally accompanying a reduction in the rate of stimulation was attenuated.	Ryanodine	47-56	latexin	Homo sapiens	62-65	
25012845-8	2014	Ryanodine (100 muM) pretreatment reduced the magnitude of the Ca(2+) signal and the area under the curve.	Ryanodine	0-9	latexin	Homo sapiens	15-18	
25012845-10	2014	Ryanodine (100 muM) caused an 81% and 47% reduction in acinar cell injury, respectively, as measured by lactate dehydrogenase leakage (P < 0.05).	Ryanodine	0-9	latexin	Homo sapiens	15-18	
24129906-4	2013	Ryanodine (50 muM) caused a robust, nifedipine (50 muM) independent, increase in SOCE activation to 8.6 muM/s.	Ryanodine	0-9	latexin	Homo sapiens	14-17	
24129906-4	2013	Ryanodine (50 muM) caused a robust, nifedipine (50 muM) independent, increase in SOCE activation to 8.6 muM/s.	Ryanodine	0-9	latexin	Homo sapiens	51-54	
24129906-4	2013	Ryanodine (50 muM) caused a robust, nifedipine (50 muM) independent, increase in SOCE activation to 8.6 muM/s.	Ryanodine	0-9	latexin	Homo sapiens	51-54	
23667860-3	2013	These effects were associated with reversible increase in endplate current amplitude, which was abolished by activation of ryanodine receptors of intracellular Ca(2+)stores with caffeine (3 mM) and ryanodine (0.5 muM).	Ryanodine	123-132	latexin	Homo sapiens	213-216