PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35532170-10 2022 Downregulation of full length FN1 and concomitant increased FN1-208 ratio resulted in decreased sulphated glycosaminoglycan deposition, as well as decreased ACAN and COL2A1 and increased ADAMTS-5, ITGB1, and ITGB5 gene expression levels. Glycosaminoglycans 106-123 fibronectin 1 Homo sapiens 30-33 2083241-1 1990 The effect of purified human plasma fibronectin on LDL-GAG and LDL-PG complex formation was studied. Glycosaminoglycans 55-58 fibronectin 1 Homo sapiens 36-47 2083241-2 1990 Fibronectin added to LDL or to GAG or even to preformed LDL-GAG-Ca2+ complexes could inhibit complex formation and dissociated preformed complexes. Glycosaminoglycans 31-34 fibronectin 1 Homo sapiens 0-11 2083241-2 1990 Fibronectin added to LDL or to GAG or even to preformed LDL-GAG-Ca2+ complexes could inhibit complex formation and dissociated preformed complexes. Glycosaminoglycans 60-63 fibronectin 1 Homo sapiens 0-11 2083241-5 1990 It appears therefore that the protein and GAG portions of PGs may not interact at the same sites of LDL and competition by fibronectin would be more efficient at the GAG binding site. Glycosaminoglycans 166-169 fibronectin 1 Homo sapiens 123-134 8307950-8 1994 These results, in combination with the ability of heparin and chondroitin sulfate to compete for binding to DNs, demonstrate that these two glycosaminoglycans interact with similar or overlapping sites in FN. Glycosaminoglycans 140-158 fibronectin 1 Homo sapiens 205-207 35532170-10 2022 Downregulation of full length FN1 and concomitant increased FN1-208 ratio resulted in decreased sulphated glycosaminoglycan deposition, as well as decreased ACAN and COL2A1 and increased ADAMTS-5, ITGB1, and ITGB5 gene expression levels. Glycosaminoglycans 106-123 fibronectin 1 Homo sapiens 60-63 6643486-2 1983 Binding of intact plasma fibronectin and its proteolytic fragments to glycosaminoglycans immobilized on agarose beads was systematically compared at different ionic strengths. Glycosaminoglycans 70-88 fibronectin 1 Homo sapiens 25-36 2483538-2 1989 3H-FN binds to Dowex beads coated with chondroitin sulfate GAG chains (CS) but not to beads coated with hyaluronic acid (HA). Glycosaminoglycans 59-62 fibronectin 1 Homo sapiens 3-5 2581830-15 1985 Conversely, the GAG increase the retention of 3H-FN in the gels. Glycosaminoglycans 16-19 fibronectin 1 Homo sapiens 49-51 2581830-17 1985 The increased retention of GAG and CSPG by the addition of FN may be due to both stabilization of binding to the collagen and trapping of matrix complexes within the gel. Glycosaminoglycans 27-30 fibronectin 1 Homo sapiens 59-61 6643486-4 1983 Fractionation of the thermolysin digest of fibronectin on the glycosaminoglycan-Sepharoses at low ionic strength revealed that three groups of fragments, i.e. Mr = 150,000-140,000, 24,000, and 16,000 (150K-140K, 24K, and 16K) fragments, were capable of binding to glycosaminoglycans with different specificities and affinities. Glycosaminoglycans 62-79 fibronectin 1 Homo sapiens 43-54 6643486-4 1983 Fractionation of the thermolysin digest of fibronectin on the glycosaminoglycan-Sepharoses at low ionic strength revealed that three groups of fragments, i.e. Mr = 150,000-140,000, 24,000, and 16,000 (150K-140K, 24K, and 16K) fragments, were capable of binding to glycosaminoglycans with different specificities and affinities. Glycosaminoglycans 264-282 fibronectin 1 Homo sapiens 43-54 6643486-9 1983 The binding of fibronectin and its fragments to glycosaminoglycans is dependent on the ionic strength. Glycosaminoglycans 48-66 fibronectin 1 Homo sapiens 15-26 6210440-5 1982 Interactions between sulfated glycosaminoglycans produced by the fibroblasts and fibronectin could also be demonstrated by affinity chromatography on immobilized plasma fibronectin and by immunoprecipitation of fibronectin in conditioned culture medium, which resulted in a coprecipitation of the sulfated glycosaminoglycans. Glycosaminoglycans 30-48 fibronectin 1 Homo sapiens 81-92 6179951-2 1982 While it has been established that fibronectin possesses binding sites for several glycosaminoglycans, it was found that only dextran sulfate and macromolecular heparin could decrease the initial rate of cell attachment to collagen. Glycosaminoglycans 83-101 fibronectin 1 Homo sapiens 35-46 6210440-5 1982 Interactions between sulfated glycosaminoglycans produced by the fibroblasts and fibronectin could also be demonstrated by affinity chromatography on immobilized plasma fibronectin and by immunoprecipitation of fibronectin in conditioned culture medium, which resulted in a coprecipitation of the sulfated glycosaminoglycans. Glycosaminoglycans 30-48 fibronectin 1 Homo sapiens 169-180 6210440-5 1982 Interactions between sulfated glycosaminoglycans produced by the fibroblasts and fibronectin could also be demonstrated by affinity chromatography on immobilized plasma fibronectin and by immunoprecipitation of fibronectin in conditioned culture medium, which resulted in a coprecipitation of the sulfated glycosaminoglycans. Glycosaminoglycans 30-48 fibronectin 1 Homo sapiens 169-180 6210440-6 1982 In these two systems, the fibronectin glycosaminoglycan bonds were broken at 0.2 M salt and were apparently weaker than the bonds responsible for the structural integrity of the matrix. Glycosaminoglycans 38-55 fibronectin 1 Homo sapiens 26-37 23707661-6 2013 RESULTS: MPO binds to the ECM proteins collagen IV and fibronectin, and this association is enhanced by the pre-incubation of these proteins with glycosaminoglycans. Glycosaminoglycans 146-164 fibronectin 1 Homo sapiens 55-66 7454730-10 1980 Glycosaminoglycans bind to collagen-fibronectin complexes resulting in a complex more stable to disruption with urea than complexes of any two of the components. Glycosaminoglycans 0-18 fibronectin 1 Homo sapiens 36-47 28222208-2 2017 Therefore, this study aims to give insight into the interaction of cancer cells exhibiting different metastatic potential (MDA-MB-231, MDA-MB-468) with surface immobilized GAG interacting with serum proteins like fibronectin. Glycosaminoglycans 172-175 fibronectin 1 Homo sapiens 213-224 27808176-3 2016 FN homes several binding sites for sulfated glycosaminoglycans (sGAG), such as heparin (Hep), which was previously shown to influence FN conformation and protein binding. Glycosaminoglycans 44-62 fibronectin 1 Homo sapiens 0-2 27808176-3 2016 FN homes several binding sites for sulfated glycosaminoglycans (sGAG), such as heparin (Hep), which was previously shown to influence FN conformation and protein binding. Glycosaminoglycans 44-62 fibronectin 1 Homo sapiens 134-136 23707661-7 2013 Correspondingly, an excess of glycosaminoglycans in solution during incubation inhibits the binding of MPO to collagen IV and fibronectin. Glycosaminoglycans 30-48 fibronectin 1 Homo sapiens 126-137 10456887-3 1999 The mechanism involves specific bacterial recruitment of heparin, glycosaminoglycans, or related sulfated polysaccharides, which in turn serve as universal binding sites for a diverse array of mammalian heparin binding proteins, including adhesive glycoproteins (vitronectin and fibronectin), inflammatory (MCP-3, PF-4, and MIP-1alpha) and immunomodulatory (gamma interferon) intermediates, and fibroblast growth factor. Glycosaminoglycans 66-84 fibronectin 1 Homo sapiens 279-290 23531422-2 2013 METHODS: To improve our understanding of ECM protein-conducting polymer interactions, we have used Atomic Force Microscopy (AFM) to elucidate the interactions of fibronectin (FN) on polypyrrole (PPy) doped with different glycosaminoglycans. Glycosaminoglycans 221-239 fibronectin 1 Homo sapiens 162-173 23531422-2 2013 METHODS: To improve our understanding of ECM protein-conducting polymer interactions, we have used Atomic Force Microscopy (AFM) to elucidate the interactions of fibronectin (FN) on polypyrrole (PPy) doped with different glycosaminoglycans. Glycosaminoglycans 221-239 fibronectin 1 Homo sapiens 175-177 11547896-5 2001 Regulatory proteins of the mammary gland that bind GAG include many growth factors and morphogens (fibroblast growth factors, hepatocyte growth factor/scatter factor, members of the midkine family, wnts), matrix proteins (collagen, fibronectin, and laminin), enzymes (lipoprotein lipase) and microbial surface proteins. Glycosaminoglycans 51-54 fibronectin 1 Homo sapiens 232-243 9437731-1 1998 Recently we have shown an evidence that a peptide, corresponding to residues Gln1892 to Gly1910, from the C-terminal heparin-binding domain of fibronectin promotes adhesion of phorbol-12-myristate 13-acetate (PMA)-treated U937 cells and binds to both integrin alpha 4 beta 1 and glycosaminoglycans on U937 cells surface. Glycosaminoglycans 279-297 fibronectin 1 Homo sapiens 143-154 9252349-6 1997 In addition, an auxiliary binding site located COOH-terminal to this fibronectin type III repeat interacted with the glycosaminoglycan component of decorin. Glycosaminoglycans 117-134 fibronectin 1 Homo sapiens 69-80