PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3058540-12 1988 Measurable increases in uptake of [35S]sulfate into GAG occurred with IL-1, baFGF, TGF-beta, h-EGF, IGF-1, bbFGF, NGF, and Forskolin. Glycosaminoglycans 52-55 insulin like growth factor 1 Homo sapiens 100-105 32715779-13 2020 (p < .05) GAG content, chondrogenic protein and gene expression level of SOX-9, COL-II, ACAN, and HIF pathway related gene (HIF-1alpha) were significantly higher in IGF-1 PLGA/PDA/PCL scaffolds group compared to other groups. Glycosaminoglycans 10-13 insulin like growth factor 1 Homo sapiens 165-170 33751850-11 2021 TGF-beta1 and IGF-1 releasing COX rods induced higher Glycosaminoglycan (GAG)/DNA amounts than the other GF releasing COX rods. Glycosaminoglycans 54-71 insulin like growth factor 1 Homo sapiens 14-19 33751850-11 2021 TGF-beta1 and IGF-1 releasing COX rods induced higher Glycosaminoglycan (GAG)/DNA amounts than the other GF releasing COX rods. Glycosaminoglycans 73-76 insulin like growth factor 1 Homo sapiens 14-19 25577208-0 2015 Bioactive IGF-1 release from collagen-GAG scaffold to enhance cartilage repair in vitro. Glycosaminoglycans 38-41 insulin like growth factor 1 Homo sapiens 10-15 32763434-5 2020 Subsequently, released IGF-1 from Coa could effectively induce chondrogenic differentiation of embedded ADSCs in the hydrogel, by showing enhanced glycosaminoglycan deposition and expression of chondrogenesis-associated genes. Glycosaminoglycans 147-164 insulin like growth factor 1 Homo sapiens 23-28 28740513-6 2017 The abundance of glycosaminoglycan (GAG) was also significantly higher in the IGF-1-MSC group. Glycosaminoglycans 17-34 insulin like growth factor 1 Homo sapiens 78-83 28740513-6 2017 The abundance of glycosaminoglycan (GAG) was also significantly higher in the IGF-1-MSC group. Glycosaminoglycans 36-39 insulin like growth factor 1 Homo sapiens 78-83 26445237-0 2015 Cotransfected human chondrocytes: over-expression of IGF-I and SOX9 enhances the synthesis of cartilage matrix components collagen-II and glycosaminoglycans. Glycosaminoglycans 138-156 insulin like growth factor 1 Homo sapiens 53-58 20178406-11 2010 RESULTS: In part I, GAG accumulation was highest for growth factor combinations including both IGF-1 and GDF-5. Glycosaminoglycans 20-23 insulin like growth factor 1 Homo sapiens 95-100 24352367-5 2014 A new computational model, based on the mechano-electrochemical mixture theory, was developed to describe competitive binding kinetics of IGF-1 with IGFBP and CSR, and associated glycosaminoglycan (GAG) biosynthesis. Glycosaminoglycans 179-196 insulin like growth factor 1 Homo sapiens 138-143 24352367-5 2014 A new computational model, based on the mechano-electrochemical mixture theory, was developed to describe competitive binding kinetics of IGF-1 with IGFBP and CSR, and associated glycosaminoglycan (GAG) biosynthesis. Glycosaminoglycans 198-201 insulin like growth factor 1 Homo sapiens 138-143 24352367-9 2014 Results indicated that the lower ratio of IGF-1 to IGFBP found in obese population reduces cartilage GAG concentration up to 18 % when compared to normal population. Glycosaminoglycans 101-104 insulin like growth factor 1 Homo sapiens 42-47 25202993-8 2014 It tuned out that the promoted GAG synthesis and USSs gene expression induced by APS-3c was mediated by the stimulated IGF1 and IGF1R gene expression, but not through directly activation of IGF1R signaling pathway. Glycosaminoglycans 31-34 insulin like growth factor 1 Homo sapiens 119-123 23899094-6 2013 Aggregates co-transduced with Ad.IGF-1/Ad.FGF-2 showed a selective expression of proteoglycans and collagen II, with limited expression of collagens I and x demonstrated by histological analyses, and had significantly greater glycosaminoglycan and collagen production than the positive control (P <=0.001). Glycosaminoglycans 226-243 insulin like growth factor 1 Homo sapiens 33-38 20178406-13 2010 GAG and type II collagen accumulation was significantly higher with IGF-1 and GDF-5. Glycosaminoglycans 0-3 insulin like growth factor 1 Homo sapiens 68-73 20178406-15 2010 CONCLUSION: Supplementation of medium with IGF-1 and GDF-5 during creation of neocartilage constructs results in increased accumulation of GAG and type II collagen and improved biomechanical properties compared with constructs created without the growth factors. Glycosaminoglycans 139-142 insulin like growth factor 1 Homo sapiens 43-48 18826340-7 2009 We found that co-expression of IGF-1 and TGF-beta1, BMP-2, or both at low doses resulted in larger aggregates, higher levels of glycosaminoglycan synthesis, stronger staining for proteoglycans and collagen type II and X, and greater expression of cartilage-specific marker genes than with either transgene alone. Glycosaminoglycans 128-145 insulin like growth factor 1 Homo sapiens 31-36 16868144-0 2006 Glycosaminoglycans increase levels of free and bioactive IGF-I in vitro. Glycosaminoglycans 0-18 insulin like growth factor 1 Homo sapiens 57-62 18571441-7 2009 RESULTS: In phase I, BMP-2 and IGF-I treatment resulted in significant, >1-fold increases in aggregate modulus, accompanied by increases in GAG production. Glycosaminoglycans 143-146 insulin like growth factor 1 Homo sapiens 31-36 18571441-9 2009 In phase II, combined treatment with BMP-2 and IGF-I increased aggregate modulus and GAG content further than either growth factor alone, while TGF-beta1 treatment alone remained the only treatment to also enhance tensile properties and collagen content. Glycosaminoglycans 85-88 insulin like growth factor 1 Homo sapiens 47-52 19662133-5 2007 The addition of the growth factors IGF-I (100 ng/mL) and TGF-beta1 (10 ng/mL) during the alginate culture and the absence of any growth factors during the high-density cell culture led to significantly higher GAG to DNA ratios and Young"s Moduli of the constructs compared to other combinations. Glycosaminoglycans 209-212 insulin like growth factor 1 Homo sapiens 35-40 17985932-10 2007 Glycosaminoglycan binding by IGFBPs can affect their IGF binding although the effects appear to differ among different IGFBPs; here, we found that heparin bound to the IGF-I.N-BP-2.C-BP-2 ternary complex, but did not cause it to dissociate. Glycosaminoglycans 0-17 insulin like growth factor 1 Homo sapiens 168-173 17315042-6 2007 The sustained level of IGF-1 overexpression resulted in significantly higher amounts of tissue formation, chondrocyte-like cells, GAG accumulation, and type II collagen production, compared to control scaffolds. Glycosaminoglycans 130-133 insulin like growth factor 1 Homo sapiens 23-28 11074061-6 2000 Since IGF-I is known as a stimulator of collagen and sulfated glycosaminoglycan biosynthesis, the high concentration of this growth factor in the umbilical cord plasma may be an agent responsible for preeclampsia-associated remodelling of the umbilical cord, which results in dysfunction in fetal circulation. Glycosaminoglycans 62-79 insulin like growth factor 1 Homo sapiens 6-11 12228017-7 2002 IGF-I constructs contained increased amounts of glycosaminoglycans and collagen and confined-compression equilibrium moduli as compared with controls; all groups had subnormal cellularity. Glycosaminoglycans 48-66 insulin like growth factor 1 Homo sapiens 0-5 12228017-8 2002 The amounts of glycosaminoglycans and collagen per unit DNA in IGF-I constructs were markedly higher than in constructs cultured in serum-supplemented medium or native cartilage. Glycosaminoglycans 15-33 insulin like growth factor 1 Homo sapiens 63-68 16796813-8 2006 35S labeling demonstrated an increased GAG synthesis in the presence of IGF1 (P<0.001). Glycosaminoglycans 39-42 insulin like growth factor 1 Homo sapiens 72-76 17053321-9 2006 The combination of IGF-I and TGF-beta1 produced higher amounts of glycosaminoglycan than TGF-beta1 alone at 8 weeks. Glycosaminoglycans 66-83 insulin like growth factor 1 Homo sapiens 19-24 12201997-9 2002 Redifferentiation with SFM with IGF-I and TGFbeta-2 showed high collagen type II expression and high GAG/DNA production regardless of which expansion medium had been used. Glycosaminoglycans 101-104 insulin like growth factor 1 Homo sapiens 32-37 11593356-7 2001 Transplantation of articular chondrocytes that overexpress human IGF-I also increased DNA synthesis and the synthesis of glycosaminoglycans by the underlying explant cartilage chondrocytes. Glycosaminoglycans 121-139 insulin like growth factor 1 Homo sapiens 65-70 11028764-3 2000 IGF-1 is a stimulator of biosynthetics of collagen and sulphated glycosaminoglycans. Glycosaminoglycans 65-83 insulin like growth factor 1 Homo sapiens 0-5 11028764-14 2000 This may be a factor, which prevents the binding of IGF-1 by BPs and facilitates the binding of IGF-1 to cells, stimulating them to produce sulphated glycosaminoglycans in Wharton"s jelly. Glycosaminoglycans 150-168 insulin like growth factor 1 Homo sapiens 52-57 11028764-14 2000 This may be a factor, which prevents the binding of IGF-1 by BPs and facilitates the binding of IGF-1 to cells, stimulating them to produce sulphated glycosaminoglycans in Wharton"s jelly. Glycosaminoglycans 150-168 insulin like growth factor 1 Homo sapiens 96-101 10809899-3 2000 IGF-I is known as a stimulator of collagen and sulphated glycosaminoglycans (GAGs) biosynthesis. Glycosaminoglycans 57-75 insulin like growth factor 1 Homo sapiens 0-5 10839203-2 2000 IGF-I is expressed in most fetal tissues and it is involved in anabolic effects on protein and sulphated glycosaminoglycans biosynthesis, cell proliferation and differentiation. Glycosaminoglycans 105-123 insulin like growth factor 1 Homo sapiens 0-5 8895319-13 1996 In summary, IGFBP-2 binding to glycosaminoglycans is dependent upon binding of IGF-I and IGF-II to IGFBP-2. Glycosaminoglycans 31-49 insulin like growth factor 1 Homo sapiens 79-84 7519608-2 1994 This study was designed to determine the role of glycosaminoglycans in altering the formation of the IGF-I.IGFBP complexes. Glycosaminoglycans 49-67 insulin like growth factor 1 Homo sapiens 101-106 8273556-6 1993 TGF-beta and IGF-I increased the amount of S-GAG in both the medium and cell surface compartments, but did not protect from IL-1-induced release. Glycosaminoglycans 45-48 insulin like growth factor 1 Homo sapiens 13-18 1613437-6 1992 More detailed analysis of extracellular-matrix component synthesis showed that basic FGF, IGF-I and insulin each caused significant increases in the synthesis of collagen and sulphated glycosaminoglycans. Glycosaminoglycans 185-203 insulin like growth factor 1 Homo sapiens 90-95 1936596-12 1991 However, IGF-I decreased the ratio of [35S]sulfate to [3H]glucosamine in proteoglycans and their glycosaminoglycan side chains. Glycosaminoglycans 97-114 insulin like growth factor 1 Homo sapiens 9-14 1700901-2 1990 This study investigates the regulation, by salt and glycosaminoglycans, of ternary (alpha-beta-gamma) complex formation, measured by incubating radioiodinated alpha-subunit with a mixture of IGF-I and IGFBP-3 and precipitating bound radioactivity with an anti-IGFBP-3 antiserum. Glycosaminoglycans 52-70 insulin like growth factor 1 Homo sapiens 191-196 7589467-1 1995 Human plasma has been shown to contain a low molecular weight factor that potentiates human IGF-I stimulation of glycosaminoglycan synthesis in chick embryo cartilage. Glycosaminoglycans 113-130 insulin like growth factor 1 Homo sapiens 92-97 1309253-0 1992 Enhancement of transforming potential of human insulinlike growth factor 1 receptor by N-terminal truncation and fusion to avian sarcoma virus UR2 gag sequence. Glycosaminoglycans 147-150 insulin like growth factor 1 Homo sapiens 47-74