PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27905556-5 2016 Here we show that in Gag-expressing cells, secretion of biologically active p17 takes place at the plasma membrane and occurs following its interaction with phosphatidylinositol-(4,5)-bisphosphate and its subsequent cleavage from the precursor Gag (Pr55Gag) operated by cellular aspartyl proteases. Glycosaminoglycans 21-24 family with sequence similarity 72 member B Homo sapiens 76-79 27905556-5 2016 Here we show that in Gag-expressing cells, secretion of biologically active p17 takes place at the plasma membrane and occurs following its interaction with phosphatidylinositol-(4,5)-bisphosphate and its subsequent cleavage from the precursor Gag (Pr55Gag) operated by cellular aspartyl proteases. Glycosaminoglycans 244-247 family with sequence similarity 72 member B Homo sapiens 76-79 21702696-3 2012 We show that the three amino acid deletion in gag p17 previously described from these LTS is not real and was a result of an alignment error. Glycosaminoglycans 46-49 family with sequence similarity 72 member B Homo sapiens 50-53 22749061-4 2012 Additionally, we identified an intronic splicing regulatory element within the p17-instability element of the Gag-ORF enhancing D1-activation. Glycosaminoglycans 110-113 family with sequence similarity 72 member B Homo sapiens 79-82 21211021-10 2011 However, antibody reactivity to gag antigens varied among the women, being 100%, 90%, 70% and 63% for p24, p17, p39 and p55, respectively. Glycosaminoglycans 32-35 family with sequence similarity 72 member B Homo sapiens 107-110 21904187-3 2011 METHODS: In four patients, we analysed by clonal analysis the viral population in gag cleavage site (p17/p24, p24/p2, p2/p7, p7/p1, p1/p6(gag)), in p6(gag), in gag-pol frameshift [p1/transframe protein (TFP)/p6(pol)] and in protease-coding region. Glycosaminoglycans 82-85 family with sequence similarity 72 member B Homo sapiens 101-104 20439606-7 2010 Baseline cleavage site substitutions in the product of the gag open reading frame at positions 128 (p17/p24) (P = 0.04) and 449 (p1/p6(gag)) (P = 0.01) were significantly more frequent in those patients not achieving virological response. Glycosaminoglycans 59-62 family with sequence similarity 72 member B Homo sapiens 100-103 15070984-2 2004 In the p17 coding region of the gag gene, a CRF02_AG-specific signature pattern was observed. Glycosaminoglycans 32-35 family with sequence similarity 72 member B Homo sapiens 7-10 17545188-4 2007 This site, Gag-30, lies within p17, the gag-encoded matrix protein. Glycosaminoglycans 11-14 family with sequence similarity 72 member B Homo sapiens 31-34 17545188-4 2007 This site, Gag-30, lies within p17, the gag-encoded matrix protein. Glycosaminoglycans 40-43 family with sequence similarity 72 member B Homo sapiens 31-34 16549978-3 2006 METHODS: We determined nucleotide sequences from the C2V3C3 and gp41 region of env and the p17 region of gag in viruses from the three infected individuals from whom specimens were available. Glycosaminoglycans 105-108 family with sequence similarity 72 member B Homo sapiens 91-94 16379605-10 2005 Gag p17 exhibited greater covariability and less diversity for HIV-1B than HIV-1C, raising the hypothesis that Gag p17 is highly immunodominant in HIV-1B and is especially important for HIV-1B vaccines. Glycosaminoglycans 0-3 family with sequence similarity 72 member B Homo sapiens 4-7 16379605-10 2005 Gag p17 exhibited greater covariability and less diversity for HIV-1B than HIV-1C, raising the hypothesis that Gag p17 is highly immunodominant in HIV-1B and is especially important for HIV-1B vaccines. Glycosaminoglycans 0-3 family with sequence similarity 72 member B Homo sapiens 115-118 16379605-10 2005 Gag p17 exhibited greater covariability and less diversity for HIV-1B than HIV-1C, raising the hypothesis that Gag p17 is highly immunodominant in HIV-1B and is especially important for HIV-1B vaccines. Glycosaminoglycans 111-114 family with sequence similarity 72 member B Homo sapiens 4-7 16379605-10 2005 Gag p17 exhibited greater covariability and less diversity for HIV-1B than HIV-1C, raising the hypothesis that Gag p17 is highly immunodominant in HIV-1B and is especially important for HIV-1B vaccines. Glycosaminoglycans 111-114 family with sequence similarity 72 member B Homo sapiens 115-118 15247563-2 2004 Subtypes were assigned by heteroduplex mobility assay or sequencing of the p17/p24 region of gag and the V3/V4 region of env and by sequencing of the protease gene. Glycosaminoglycans 93-96 family with sequence similarity 72 member B Homo sapiens 75-78 15117457-4 2004 Gag p17 and env-V3 nucleotide sequences of seroconvertors in our subjects were quite similar to the CS and conserved for at least 9 and 6 years postinfection, respectively. Glycosaminoglycans 0-3 family with sequence similarity 72 member B Homo sapiens 4-7 12643279-7 2003 The region encompassing gag p17 to env C2-V3-C3 was amplified by the polymerase chain reaction followed by direct sequencing. Glycosaminoglycans 24-27 family with sequence similarity 72 member B Homo sapiens 28-31 11807313-3 2002 Gag sequences with a discrepant subtype between p17 and p24 were analysed further to indicate approximate sites of recombination. Glycosaminoglycans 0-3 family with sequence similarity 72 member B Homo sapiens 48-51 12596720-3 2003 In this study we genetically characterized a set of samples displaying the culture-negative phenotype by sequencing the nucleotides of three genomic regions: the p17 region of the gag gene, the C2V3C3 fragment of the env gene, and the nef gene. Glycosaminoglycans 180-183 family with sequence similarity 72 member B Homo sapiens 162-165 11779356-2 2001 There was a low degree of heterogeneity of gag p17 matrix sequences in nontransmitting mothers compared with our previously analyzed mother-infant pairs" sequences. Glycosaminoglycans 43-46 family with sequence similarity 72 member B Homo sapiens 47-50 11281711-2 2001 DNA sequences encoding p17 of B- and C-subtype were cloned from respective gag sequences. Glycosaminoglycans 75-78 family with sequence similarity 72 member B Homo sapiens 23-26 11118069-3 2000 In the present study, we determined env (C2/V3) and gag (p17) subtypes of 25 specimens from central Myanmar (Mandalay). Glycosaminoglycans 52-55 family with sequence similarity 72 member B Homo sapiens 57-60 10823876-6 2000 The results show that 3 out of 46 peptides spanning p17(Gag) and p24(Gag) sequences tested contain two-thirds of the dominant Gag-specific epitopes, irrespective of the clade, ethnicity, or age group studied. Glycosaminoglycans 56-59 family with sequence similarity 72 member B Homo sapiens 52-55 10331444-2 1999 To characterize the HIV-1 subtypes circulating in this area, we have examined a 330-bp fragment of the p17 region of the gag gene of HIV-1 strains obtained from 70 patients (55 mothers, 15 children), of whom 61 were epidemiologically unlinked. Glycosaminoglycans 121-124 family with sequence similarity 72 member B Homo sapiens 103-106 10772536-2 2000 Phylogenetic sequence analysis of a fragment of 729 base pairs (bp) covering the Gag-coding region for half of p24 and all of p17 revealed the gag subtype of all 60 viruses included in the study: A (n = 20), B (n = 12), C (n = 7), D (n = 10), E (n = 3), F (n = 4), G (n = 3), and H (n = 1). Glycosaminoglycans 143-146 family with sequence similarity 72 member B Homo sapiens 126-129 10710214-3 2000 From the latter experiments, we conclude that Gag proteins that include p17, and perhaps also p7, sequences flanking the central p24 capsid protein, are better stimulants than proteins that comprise only p24 sequences. Glycosaminoglycans 46-49 family with sequence similarity 72 member B Homo sapiens 72-75 10331444-8 1999 This level of gag(p17) gene variation in the DRC is considerably greater than previously appreciated. Glycosaminoglycans 14-17 family with sequence similarity 72 member B Homo sapiens 18-21 9815256-8 1998 Antigenic variation was also detected in the p17 Gag epitope; a dominant viral variant present in the patient was well recognized by a specific CD4(+) T lymphocyte line, whereas several natural mutants were not. Glycosaminoglycans 49-52 family with sequence similarity 72 member B Homo sapiens 45-48 10482050-10 1999 Interestingly, we also identified a dually infected individual with viruses belonging to subtypes B and F, as demonstrated by molecular cloning analysis of the env V3 and the gag p17 regions. Glycosaminoglycans 175-178 family with sequence similarity 72 member B Homo sapiens 179-182 8837392-7 1996 In contrast, sequences of the gag p17 gene and the regulatory genes nef and vif were homogeneous and revealed a very high homology, suggesting that the child had been infected by the mother. Glycosaminoglycans 30-33 family with sequence similarity 72 member B Homo sapiens 34-37 9794421-3 1998 The dominant in vivo activated CTL response was directed against two overlapping Gag CTL epitopes in an area of p17 known to be essential for viral replication. Glycosaminoglycans 81-84 family with sequence similarity 72 member B Homo sapiens 112-115 9684349-14 1998 In the doughnut-shaped particles, Gag p17 and p24 proteins exist facing each other against an inner electron-dense ring, suggesting that the inner ring consists of a precursor Gag protein showing a defect at the viral proteinase. Glycosaminoglycans 34-37 family with sequence similarity 72 member B Homo sapiens 38-41 9684349-14 1998 In the doughnut-shaped particles, Gag p17 and p24 proteins exist facing each other against an inner electron-dense ring, suggesting that the inner ring consists of a precursor Gag protein showing a defect at the viral proteinase. Glycosaminoglycans 176-179 family with sequence similarity 72 member B Homo sapiens 38-41 9517991-1 1998 OBJECTIVE: To investigate the suitability of HIV sequence analysis, based on the p17 region of the gag gene, to characterize the sexual networks in and around a trading town in south-west Uganda. Glycosaminoglycans 99-102 family with sequence similarity 72 member B Homo sapiens 81-84 9300048-1 1997 We have sequenced the p17 coding regions of the gag gene from 211 patients infected either through injecting drug use (IDU) or by sexual intercourse between men from six cities in Scotland, N. England, N. Ireland, and the Republic of Ireland. Glycosaminoglycans 48-51 family with sequence similarity 72 member B Homo sapiens 22-25 7853521-4 1995 A comparison of the sequences of the V1-V2 and the V3 coding regions of the envelope gene and the p17 region of the gag gene showed that the donor-recipient pairs were tightly clustered in all gene segments, but away from local and published transmission controls. Glycosaminoglycans 116-119 family with sequence similarity 72 member B Homo sapiens 98-101 8315575-2 1993 In this study, we analyzed the immune response to two recombinant gag proteins, p24 and p17, in order to evaluate their diagnostic or prognostic significance. Glycosaminoglycans 66-69 family with sequence similarity 72 member B Homo sapiens 88-91 8328911-3 1993 The specific proteolytic activity of the recombinant protease on the gag and pol precursor proteins was used for the generation of processed gag (p 17, p 24, p 16) and pol (RT/RNaseH, IN) proteins. Glycosaminoglycans 69-72 family with sequence similarity 72 member B Homo sapiens 146-150 8497055-4 1993 Paradoxically, substantial sequence variability was found in the normally high conserved gag gene (encoding p17) in most of the preseroconversion samples. Glycosaminoglycans 89-92 family with sequence similarity 72 member B Homo sapiens 108-111 1584067-2 1992 We found that a mouse monoclonal antibody to p17, V17 recognizes the mature p17 but not the unprocessed Gag proteins containing the entire p17 moiety. Glycosaminoglycans 104-107 family with sequence similarity 72 member B Homo sapiens 45-48 1282012-7 1992 In contrast, target cells coated with the peptide gag aa 129-135, corresponding to the p17/p24 cleavage region of the gag precursor, were not killed. Glycosaminoglycans 50-53 family with sequence similarity 72 member B Homo sapiens 87-90 1282012-7 1992 In contrast, target cells coated with the peptide gag aa 129-135, corresponding to the p17/p24 cleavage region of the gag precursor, were not killed. Glycosaminoglycans 118-121 family with sequence similarity 72 member B Homo sapiens 87-90 1744586-5 1991 HIV gag-specific CTL precursors are identified at frequencies of 1/1700 to 1/17,000 lymphocytes and are made up of cells with both p17 and p24 specificities. Glycosaminoglycans 4-7 family with sequence similarity 72 member B Homo sapiens 131-134 1715884-10 1991 MAbs which recognize conserved epitopes of gag-encoded lentivirus proteins (CA p27 and MA p17) are valuable tools. Glycosaminoglycans 43-46 family with sequence similarity 72 member B Homo sapiens 90-93 2785991-7 1989 We conclude that the myristylated HIV-1 gag p55 precursor is initially cleaved at random either at the p17/p24 junction or at two sites between p24 and p15 proteins, resulting in three intermediates (p41a, p41b, and p39) which are subsequently cleaved to yield mature gag proteins. Glycosaminoglycans 40-43 family with sequence similarity 72 member B Homo sapiens 103-106 34512672-11 2021 Reactivity to one of these clusters located in gag p17 was inversely correlated with viral load set point in an independent cohort of non-controllers. Glycosaminoglycans 47-50 family with sequence similarity 72 member B Homo sapiens 51-54 3049075-12 1988 Cleavage of the gag precursor results in the mature capsid protein, p17. Glycosaminoglycans 16-19 family with sequence similarity 72 member B Homo sapiens 68-71 2447023-5 1988 Putative gag proteins of p55, p24 and p17 were recognized by sera of human AIDS patients, but the corresponding env proteins of 32-40 and 120 kDa showed only weak cross-reactivity with those of HIV. Glycosaminoglycans 9-12 family with sequence similarity 72 member B Homo sapiens 38-41