PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26223367-0	2015	Flexible Linker Modulates Glycosaminoglycan Affinity of Decorin Binding Protein A. Decorin binding protein A (DBPA) is a glycosaminoglycan (GAG)-binding adhesin found on the surface of the bacterium Borrelia burgdorferi (B. burgdorferi), the causative agent of Lyme disease.	Glycosaminoglycans	121-138	Y-box binding protein 3	Homo sapiens	110-114	
16368999-3	2006	Three surface-localized GAG-binding bacterial ligands, Bgp, DbpA, and DbpB, have been previously identified, but recent studies suggested that at least one additional GAG-binding ligand is expressed on the spirochetal surface when the spirochete is adapted to the mammalian host environment.	Glycosaminoglycans	24-27	Y-box binding protein 3	Homo sapiens	60-64	
12603746-5	2003	Three B. burgdorferi surface proteins, Bgp, DbpA and DbpB, have been demonstrated previously to bind to GAGs or to GAG-containing molecules, and we show here that recombinant derivatives of each of these proteins were able to bind to purified heparin and dermatan sulphate.	Glycosaminoglycans	104-108	Y-box binding protein 3	Homo sapiens	44-48	
12603746-5	2003	Three B. burgdorferi surface proteins, Bgp, DbpA and DbpB, have been demonstrated previously to bind to GAGs or to GAG-containing molecules, and we show here that recombinant derivatives of each of these proteins were able to bind to purified heparin and dermatan sulphate.	Glycosaminoglycans	104-107	Y-box binding protein 3	Homo sapiens	44-48	
26223367-0	2015	Flexible Linker Modulates Glycosaminoglycan Affinity of Decorin Binding Protein A. Decorin binding protein A (DBPA) is a glycosaminoglycan (GAG)-binding adhesin found on the surface of the bacterium Borrelia burgdorferi (B. burgdorferi), the causative agent of Lyme disease.	Glycosaminoglycans	140-143	Y-box binding protein 3	Homo sapiens	110-114	
26223367-2	2015	Interestingly, DBPA from different strains (B31, N40, and PBr) show significant differences in GAG affinities, but the structural basis for the differences is not clear.	Glycosaminoglycans	95-98	Y-box binding protein 3	Homo sapiens	15-19	
26223367-3	2015	In this study, we show that GAG affinity of N40 DBPA is modulated in part by flexible segments that control access to the GAG binding site, such that shortening of the linker leads to higher GAG affinity when analyzed using ELISA, gel mobility shift assay, solution NMR, and isothermal titration calorimetry.	Glycosaminoglycans	28-31	Y-box binding protein 3	Homo sapiens	48-52	
26223367-3	2015	In this study, we show that GAG affinity of N40 DBPA is modulated in part by flexible segments that control access to the GAG binding site, such that shortening of the linker leads to higher GAG affinity when analyzed using ELISA, gel mobility shift assay, solution NMR, and isothermal titration calorimetry.	Glycosaminoglycans	122-125	Y-box binding protein 3	Homo sapiens	48-52	
26223367-3	2015	In this study, we show that GAG affinity of N40 DBPA is modulated in part by flexible segments that control access to the GAG binding site, such that shortening of the linker leads to higher GAG affinity when analyzed using ELISA, gel mobility shift assay, solution NMR, and isothermal titration calorimetry.	Glycosaminoglycans	122-125	Y-box binding protein 3	Homo sapiens	48-52	
25695518-2	2015	DBPA facilitates the bacteria"s colonization of human tissue by adhering to glycosaminoglycan (GAG), a sulfated polysaccharide.	Glycosaminoglycans	76-93	Y-box binding protein 3	Homo sapiens	0-4	
25695518-2	2015	DBPA facilitates the bacteria"s colonization of human tissue by adhering to glycosaminoglycan (GAG), a sulfated polysaccharide.	Glycosaminoglycans	95-98	Y-box binding protein 3	Homo sapiens	0-4	
25695518-3	2015	Interestingly, DBPA sequence variation among different strains of Borrelia spirochetes is high, resulting in significant differences in their GAG affinities.	Glycosaminoglycans	142-145	Y-box binding protein 3	Homo sapiens	15-19	
25695518-7	2015	In particular, the C-terminus of PBr DBPA, unlike C-termini from B31 and N40 DBPAs, is positioned away from the GAG-binding pocket and the linker between helices one and two of PBr DBPA is highly structured and retracted from the GAG-binding pocket.	Glycosaminoglycans	112-115	Y-box binding protein 3	Homo sapiens	37-41	
25695518-7	2015	In particular, the C-terminus of PBr DBPA, unlike C-termini from B31 and N40 DBPAs, is positioned away from the GAG-binding pocket and the linker between helices one and two of PBr DBPA is highly structured and retracted from the GAG-binding pocket.	Glycosaminoglycans	230-233	Y-box binding protein 3	Homo sapiens	37-41	
25695518-8	2015	The repositioning of the C-terminus allowed the formation of an extra GAG-binding epitope in PBr DBPA and the retracted linker gave GAG ligands more access to the GAG-binding epitopes than other DBPAs.	Glycosaminoglycans	70-73	Y-box binding protein 3	Homo sapiens	97-101	
18195034-1	2008	Both decorin-binding proteins (DbpA and DbpB) of the Lyme disease spirochete Borrelia burgdorferi bind decorin and glycosaminoglycans, two important building blocks of proteoglycans that are abundantly found in the extracellular matrix (ECM) and connective tissues as well as on cell surfaces of mammals.	Glycosaminoglycans	115-133	Y-box binding protein 3	Homo sapiens	31-35