PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15126635-0	2004	Nedd4.1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding.	Glycosaminoglycans	83-86	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	0-5	
15126635-2	2004	The Gag proteins of oncoretroviruses possess a PPxY motif that recruits a ubiquitin ligase from the Nedd4 family, whereas those of the human immunodeficiency virus interact through a PTAP motif with Tsg101, a protein of the ESCRT-1 complex.	Glycosaminoglycans	4-7	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	100-105	
15126635-5	2004	We show that Nedd4.1, but not Nedd4.2, is recruited by the PPPY motif of Gag and subsequently catalyzes Gag ubiquitination.	Glycosaminoglycans	73-76	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	13-20	
15126635-5	2004	We show that Nedd4.1, but not Nedd4.2, is recruited by the PPPY motif of Gag and subsequently catalyzes Gag ubiquitination.	Glycosaminoglycans	104-107	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	13-20	
15126635-6	2004	We also demonstrate that Gag interacts first with Nedd4.1 at the plasma membrane and then with Tsg101 in late endosomes/MVBs.	Glycosaminoglycans	25-28	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	50-57	
15126635-8	2004	Our findings indicate that Nedd4.1 and Tsg101 act successively in the assembly process of HTLV-1 to ensure proper Gag trafficking through the endocytic pathway up to late endosomes where the late steps of retroviral release occur.	Glycosaminoglycans	114-117	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	27-32