PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11718104-1	2001	Addition of human recombinant interleukin 6 (IL-6) to culture medium (supplemented MEM without or with 10% fetal calf serum (FCS)) of human skin fibroblasts exerted a stimulating effect in a dose-dependent manner on glycosaminoglycan (GAG) synthesis, including hyaluronic acid (hyaluronan) synthesis, of young (phase-II) skin fibroblasts in concentrations of 1 ng/ml and 10 ng/ml.	Glycosaminoglycans	216-233	interleukin 6	Homo sapiens	30-43	
28000839-11	2017	Sulfated glycosaminoglycan production was also reduced upon chondrogenic differentiation in the presence of IL-6, but not IL-8.	Glycosaminoglycans	9-26	interleukin 6	Homo sapiens	108-112	
25198673-2	2014	We also examined mucosal expression of IL-6, which stimulates excess GAG synthesis in disorders such as Grave"s ophthalmopathy.	Glycosaminoglycans	69-72	interleukin 6	Homo sapiens	39-43	
23983782-6	2013	Results showed that the hyperglycemia-induced GAG alterations in the cell surface perlecan as well as in the ECM indeed upregulated the expressions of IL-6, IL-8, and MCP-1 and the activities of MMP-2 and MMP-9 and downregulated the expressions of TIMP-2.	Glycosaminoglycans	46-49	interleukin 6	Homo sapiens	151-155	
1457283-13	1992	Interleukin-6 has been shown to stimulate fibroblast synthesis of collagen and glycosaminoglycans.	Glycosaminoglycans	79-97	interleukin 6	Homo sapiens	0-13	
1940439-4	1991	Although the effective stimulating concentrations of IL-6 were within the range (approximately 100 ng/ml) we found produced by rhIL-1 beta-treated fibroblast cultures, rhIL-1 beta at 0.2-1.0 ng/ml induced significantly greater amounts of collagen and GAG than the maximum effective concentrations of IL-6.	Glycosaminoglycans	251-254	interleukin 6	Homo sapiens	53-57	
23897063-5	2013	Depletion of HIV-specific CD8(+) IL-10(+) cells from PBMCs led to upregulation of CD38 on CD14(+) monocytes together with increased IL-6 production, in response to gag stimulation.	Glycosaminoglycans	164-167	interleukin 6	Homo sapiens	132-136	
23206933-9	2012	Adding IL-6 increased GAG production by healthy chondrocytes and decreased GAG release by osteoarthritic chondrocytes (P < 0.05).	Glycosaminoglycans	22-25	interleukin 6	Homo sapiens	7-11	
23206933-9	2012	Adding IL-6 increased GAG production by healthy chondrocytes and decreased GAG release by osteoarthritic chondrocytes (P < 0.05).	Glycosaminoglycans	75-78	interleukin 6	Homo sapiens	7-11	
23206933-10	2012	Inhibition of IL-6 present in osteoarthritic synovial fluid showed a trend towards decreased GAG content of the explants (P = 0.06).	Glycosaminoglycans	93-96	interleukin 6	Homo sapiens	14-18	
19790045-11	2009	The catabolic effects of injury plus TNFalpha appeared partly due to endogenous IL-6, since GAG loss was partially abrogated by an IL-6-blocking Fab.	Glycosaminoglycans	92-95	interleukin 6	Homo sapiens	131-135	
17982709-2	2007	We therefore investigated the presence of urinary IL-6 in patients with BPS/IC to find a possible correlation with the symptoms before and after glycosaminoglycan substitution therapy.	Glycosaminoglycans	145-162	interleukin 6	Homo sapiens	50-54	
14653390-4	2003	RESULTS: The results showed that IL-6 elicited an inhibitory effect on collagen and GAG levels in CLP fibroblasts by lowering hyaluronan and dermatan sulfate secretion.	Glycosaminoglycans	84-87	interleukin 6	Homo sapiens	33-37	
11718104-1	2001	Addition of human recombinant interleukin 6 (IL-6) to culture medium (supplemented MEM without or with 10% fetal calf serum (FCS)) of human skin fibroblasts exerted a stimulating effect in a dose-dependent manner on glycosaminoglycan (GAG) synthesis, including hyaluronic acid (hyaluronan) synthesis, of young (phase-II) skin fibroblasts in concentrations of 1 ng/ml and 10 ng/ml.	Glycosaminoglycans	216-233	interleukin 6	Homo sapiens	45-49	
11718104-1	2001	Addition of human recombinant interleukin 6 (IL-6) to culture medium (supplemented MEM without or with 10% fetal calf serum (FCS)) of human skin fibroblasts exerted a stimulating effect in a dose-dependent manner on glycosaminoglycan (GAG) synthesis, including hyaluronic acid (hyaluronan) synthesis, of young (phase-II) skin fibroblasts in concentrations of 1 ng/ml and 10 ng/ml.	Glycosaminoglycans	235-238	interleukin 6	Homo sapiens	30-43	
11718104-1	2001	Addition of human recombinant interleukin 6 (IL-6) to culture medium (supplemented MEM without or with 10% fetal calf serum (FCS)) of human skin fibroblasts exerted a stimulating effect in a dose-dependent manner on glycosaminoglycan (GAG) synthesis, including hyaluronic acid (hyaluronan) synthesis, of young (phase-II) skin fibroblasts in concentrations of 1 ng/ml and 10 ng/ml.	Glycosaminoglycans	235-238	interleukin 6	Homo sapiens	45-49	
11067924-10	2000	This interaction will tend to retain IL-6 close to its sites of secretion in the tissues by binding to heparin-like glycosaminoglycans, thus favoring a paracrine mode of activity.	Glycosaminoglycans	116-134	interleukin 6	Homo sapiens	37-41