PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35416346-5 2022 Unexpectedly, when SIRT1 was activated, while ACAN was enhanced, glycosaminoglycans (GAGs) were reduced, paralleled by down regulation of gene expression for N-acetylgalactosaminyltransferase type 1 (GALNT1) responsible for GAG chain initiation/elongation. Glycosaminoglycans 224-227 aggrecan Homo sapiens 46-50 24338203-8 2014 Real-time-quantitative PCR showed that sesamin promoted the expression of the genes encoding the core protein (ACAN) of the major CS-PG aggrecan and the biosynthetic enzymes (XYLT1, XYLT2, CHSY1 and CHPF) required for the synthesis of CS-GAG side chains. Glycosaminoglycans 238-241 aggrecan Homo sapiens 111-115