PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34712574-2	2021	It is caused by bi-allelic loss-of-function mutations in SGSH encoding sulphamidase, a lysosomal enzyme required for heparan sulphate glycosaminoglycan (HS GAG) degradation, that results in the progressive build-up of HS GAGs in multiple tissues most notably the central nervous system (CNS).	Glycosaminoglycans	156-159	N-sulfoglucosamine sulfohydrolase	Homo sapiens	71-83	
34712574-2	2021	It is caused by bi-allelic loss-of-function mutations in SGSH encoding sulphamidase, a lysosomal enzyme required for heparan sulphate glycosaminoglycan (HS GAG) degradation, that results in the progressive build-up of HS GAGs in multiple tissues most notably the central nervous system (CNS).	Glycosaminoglycans	221-225	N-sulfoglucosamine sulfohydrolase	Homo sapiens	71-83	
27331076-3	2016	We treated MPS IIIA mice at 1, 2, 3, 6, and 9 months of age with an intravenous injection of scAAV9-U1a-hSGSH vector, leading to restoration of SGSH activity and reduction of glycosaminoglycans (GAG) throughout the central nervous system (CNS) and somatic tissues at a dose of 5E12 vg/kg.	Glycosaminoglycans	175-193	N-sulfoglucosamine sulfohydrolase	Homo sapiens	104-109	
27331076-3	2016	We treated MPS IIIA mice at 1, 2, 3, 6, and 9 months of age with an intravenous injection of scAAV9-U1a-hSGSH vector, leading to restoration of SGSH activity and reduction of glycosaminoglycans (GAG) throughout the central nervous system (CNS) and somatic tissues at a dose of 5E12 vg/kg.	Glycosaminoglycans	195-198	N-sulfoglucosamine sulfohydrolase	Homo sapiens	104-109	
27491210-1	2016	Mucopolysaccharidosis type IIIA (MPS-IIIA) is a childhood metabolic neuropathology caused by the inherited deficiency of the lysosomal enzyme sulfamidase and is characterized by the accumulation of undegraded glycosaminoglycans in the lysosomes of cells and tissues of affected patients.	Glycosaminoglycans	209-227	N-sulfoglucosamine sulfohydrolase	Homo sapiens	0-31	
23863627-3	2013	Mucopolysaccharidosis type IIIA (MPS IIIA) is an autosomic recessive LSD caused by a deficiency in sulfamidase, a sulfatase involved in the stepwise degradation of glycosaminoglycan (GAG) heparan sulfate.	Glycosaminoglycans	164-187	N-sulfoglucosamine sulfohydrolase	Homo sapiens	0-31