PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9029728-9	1997	We have recently shown that P450c17 must be phosphorylated on serine and threonine residues by a cAMP-dependent protein kinase to acquire 17,20 lyase activity.	Threonine	73-82	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	28-35	
9029728-14	1997	Alternatively, the affinity of P450c17 for redox partners may be selectively increased by Ser/Thr phosphorylation, or selectively decreased by certain mutations in the redox partner binding site, in either case altering an electrostatic interaction between P450c17 and the redox partner.	Threonine	94-97	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	31-38	
20160131-4	2010	One factor favoring more efficient electron transfer and 17,20 lyase activity is cAMP-dependent serine/threonine phosphorylation of P450c17.	Threonine	103-112	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	132-139	
20534731-10	2010	Time-course experiments revealed that a short cAMP stimulation augmented threonine phosphorylation of P450c17 but did not increase 17,20-lyase activity.	Threonine	73-82	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	102-109	
7479852-3	1995	We show that human P450c17 is phosphorylated on serine and threonine residues by a cAMP-dependent protein kinase.	Threonine	59-68	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	19-26	
8504753-4	1993	We used site-directed mutagenesis to construct expression vectors for the conservative P450c17 mutations Ser106-->Thr and Ser106-->Ala.	Threonine	117-120	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	87-94	
25224484-5	2015	Third, the serine/threonine phosphorylation of P450c17 itself promotes 17,20 lyase activity, again apparently by promoting the interaction of P450c17 with POR.	Threonine	18-27	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	47-54	
25224484-5	2015	Third, the serine/threonine phosphorylation of P450c17 itself promotes 17,20 lyase activity, again apparently by promoting the interaction of P450c17 with POR.	Threonine	18-27	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	142-149	
23836902-3	2013	These are increased amounts of POR, the allosteric action of cytochrome b5 to promote POR-P450c17 interaction, and Ser/Thr phosphorylation of P450c17, which also appears to promote POR-P450c17 interaction.	Threonine	119-122	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	142-149	
23836902-3	2013	These are increased amounts of POR, the allosteric action of cytochrome b5 to promote POR-P450c17 interaction, and Ser/Thr phosphorylation of P450c17, which also appears to promote POR-P450c17 interaction.	Threonine	119-122	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	142-149	
20160131-8	2010	Using this vector, we explored P450c17 phosphorylation by mutagenesis of Ser and/or Thr residues to Asp or Glu to mimic the approximate size and charge of phospho-Ser or phospho-Thr.	Threonine	84-87	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	31-38	
16616104-0	2006	Mutagenesis of putative serine-threonine phosphorylation sites proximal to Arg255 of human cytochrome P450c17 does not selectively promote its 17,20-lyase activity.	Threonine	31-40	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	91-109	
16616104-1	2006	OBJECTIVE: To investigate the role of serine-threonine phosphorylation on the activity of human P450c17.	Threonine	45-54	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	96-103