PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10531390-8 1999 Three-dimensional models built on the basis of the predicted structure of rhodopsin showed that Tyr(308) of the beta(2)AR covered the binding pocket formed by TM2 and TM7 from the upper side, and Thr(117) of the beta(1)AR located in the middle of the binding pocket to provide a hydrogen bonding for the beta(1)-selective agonists. Threonine 0-3 adrenoceptor beta 2 Homo sapiens 112-121 13680034-1 2003 OBJECTIVE: It has been shown that arginine to glycine (Arg16Gly), glutamine to glutamic acid (Gln27Glu) and threonine to isoleucine (Thr164Ile) exchanges in codons 16, 27 and 164, respectively, of the beta 2-adrenergic receptor (B2AR) gene significantly alter receptor function. Threonine 108-117 adrenoceptor beta 2 Homo sapiens 201-227 13680034-1 2003 OBJECTIVE: It has been shown that arginine to glycine (Arg16Gly), glutamine to glutamic acid (Gln27Glu) and threonine to isoleucine (Thr164Ile) exchanges in codons 16, 27 and 164, respectively, of the beta 2-adrenergic receptor (B2AR) gene significantly alter receptor function. Threonine 108-117 adrenoceptor beta 2 Homo sapiens 229-233 11279203-13 2001 In addition, we identify a beta-arrestin mutant with enhanced affinity for the agonist-activated beta2-adrenergic receptor that traffics into endocytic vesicles with receptors that lack serine/threonine clusters and normally dissociate from wild-type beta-arrestin at the plasma membrane. Threonine 193-202 adrenoceptor beta 2 Homo sapiens 97-122 11778498-5 2000 The beta 2-AR 164 loci: Thr/Thr genotype accounts for 30%, Thr/Ile 53% and Ile/Ile 17%. Threonine 24-27 adrenoceptor beta 2 Homo sapiens 4-13 11778498-5 2000 The beta 2-AR 164 loci: Thr/Thr genotype accounts for 30%, Thr/Ile 53% and Ile/Ile 17%. Threonine 28-31 adrenoceptor beta 2 Homo sapiens 4-13 11778498-5 2000 The beta 2-AR 164 loci: Thr/Thr genotype accounts for 30%, Thr/Ile 53% and Ile/Ile 17%. Threonine 28-31 adrenoceptor beta 2 Homo sapiens 4-13 11778498-10 2000 The frequency of genotype beta 2-AR 164 loci in asthmatics: Thr/Thr genotype accounts for 10%, Thr/Ile 83% and Ile/Ile 7%. Threonine 60-63 adrenoceptor beta 2 Homo sapiens 26-35 11778498-10 2000 The frequency of genotype beta 2-AR 164 loci in asthmatics: Thr/Thr genotype accounts for 10%, Thr/Ile 83% and Ile/Ile 7%. Threonine 64-67 adrenoceptor beta 2 Homo sapiens 26-35 11778498-10 2000 The frequency of genotype beta 2-AR 164 loci in asthmatics: Thr/Thr genotype accounts for 10%, Thr/Ile 83% and Ile/Ile 7%. Threonine 64-67 adrenoceptor beta 2 Homo sapiens 26-35 12167654-4 2002 In the beta(2) adrenergic receptor, mutation of Cys(6.47) to Thr, which in an alpha-helix has a different rotamer distribution from Cys and Ser, produced a constitutively active receptor, whereas the Ser mutant was similar to wild-type receptor. Threonine 61-64 adrenoceptor beta 2 Homo sapiens 7-34 11516429-1 2001 beta(2)-adrenoceptors (beta(2)AR) are polymorphic at amino acid 164 (Thr or Ile) of the fourth transmembrane domain. Threonine 69-72 adrenoceptor beta 2 Homo sapiens 0-21 11516429-1 2001 beta(2)-adrenoceptors (beta(2)AR) are polymorphic at amino acid 164 (Thr or Ile) of the fourth transmembrane domain. Threonine 69-72 adrenoceptor beta 2 Homo sapiens 23-32 1849641-6 1991 We replaced four serine and threonine residues located within a 10-amino acid segment of this domain of beta 2AR and thereby prevented agonist-promoted phosphorylation, sequestration, and rapid desensitization of the adenylyl cyclase response. Threonine 28-37 adrenoceptor beta 2 Homo sapiens 104-112 8662852-8 1996 Increasing the stoichiometry of GRK2-mediated beta2AR phosphorylation from approximately 1.0 to 5.0 mol Pi/mol receptor increases the stoichiometry of phosphorylation of Thr-384, Ser-396, Ser-401, and Ser-407 rather than increasing the number of phosphoacceptor sites. Threonine 170-173 adrenoceptor beta 2 Homo sapiens 46-53 2836733-6 1988 Here we report that prevention of agonist-stimulated beta 2-adrenergic receptor (beta 2AR) phosphorylation by truncation of its serine and threonine-rich phosphate acceptor segment delays the onset of desensitization. Threonine 139-148 adrenoceptor beta 2 Homo sapiens 53-79 2836733-6 1988 Here we report that prevention of agonist-stimulated beta 2-adrenergic receptor (beta 2AR) phosphorylation by truncation of its serine and threonine-rich phosphate acceptor segment delays the onset of desensitization. Threonine 139-148 adrenoceptor beta 2 Homo sapiens 81-89 32067279-6 2020 In our study, we found that Abeta-M expression slowly induced cell apoptosis within 48 hours after transfection, beta2 adrenergic receptor (beta2AR) interacted with Abeta-M in the pull-down and the yeast two-hybrid assays, and Abeta-M played a major role in inducing phosphorylation of Tau at Ser-214, c-Jun N-terminal kinase (JNK) at Thr-183/Tyr-185, p70 ribosomal protein S6 kinase (p70S6K) at Thr-389. Threonine 335-338 adrenoceptor beta 2 Homo sapiens 113-138 26902407-2 2016 Internalization of beta2AR is initiated by phosphorylations of certain serines and threonines by cAMP dependent protein kinase A (PKA) and G protein-coupled receptor kinases (GRK). Threonine 83-93 adrenoceptor beta 2 Homo sapiens 19-26 30120106-7 2018 Interestingly, ISO activation of beta2AR also induced threonine phosphorylation of the IL-2Rbeta. Threonine 54-63 adrenoceptor beta 2 Homo sapiens 33-40 29053759-1 2017 The natural variant C491T (rs1800088) in ADRB2 gene substitutes Threonine to Isoleucine at 164th position in beta2AR and results in receptor sequestration and altered binding of agonists. Threonine 64-73 adrenoceptor beta 2 Homo sapiens 41-46 29053759-1 2017 The natural variant C491T (rs1800088) in ADRB2 gene substitutes Threonine to Isoleucine at 164th position in beta2AR and results in receptor sequestration and altered binding of agonists. Threonine 64-73 adrenoceptor beta 2 Homo sapiens 109-116 17569809-1 2007 BACKGROUND: Beta2-adrenergic receptor Thr164Ile (threonine (Thr) is replaced by an isoleucine (Ile) at codon 164) polymorphism was postulated to contribute to lower exercise tolerance and poor prognosis in patients with congestive heart failure. Threonine 49-58 adrenoceptor beta 2 Homo sapiens 12-37 21868357-4 2011 The beta(2)-adrenergic receptor (beta(2)AR) has many serine and threonine residues in the carboxyl-terminal tail and the intracellular loops, which are potential sites of phosphorylation. Threonine 64-73 adrenoceptor beta 2 Homo sapiens 4-31 21868357-4 2011 The beta(2)-adrenergic receptor (beta(2)AR) has many serine and threonine residues in the carboxyl-terminal tail and the intracellular loops, which are potential sites of phosphorylation. Threonine 64-73 adrenoceptor beta 2 Homo sapiens 33-42 17569809-1 2007 BACKGROUND: Beta2-adrenergic receptor Thr164Ile (threonine (Thr) is replaced by an isoleucine (Ile) at codon 164) polymorphism was postulated to contribute to lower exercise tolerance and poor prognosis in patients with congestive heart failure. Threonine 38-41 adrenoceptor beta 2 Homo sapiens 12-37