PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28578803-3 2017 Based on our previous findings indicating c-Abl hyperphosphorylation on tyrosine (Y) 412 and threonine (T) 735 upon beta1-integrin inhibition, we hypothesized c-Abl tyrosine kinase as an important mediator of beta1-integrin signaling for radioresistance. Threonine 93-102 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 159-164 30704478-10 2019 We report a novel mechanism and identified strong c-Abl threonine 735 phosphorylation (pAblT735) mediated by the type-IV secretion system (T4SS) effector D-glycero-beta-D-manno-heptose-1,7-bisphosphate (betaHBP) and protein kinase C (PKC) as a new c-Abl kinase. Threonine 56-65 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 50-55 30704478-10 2019 We report a novel mechanism and identified strong c-Abl threonine 735 phosphorylation (pAblT735) mediated by the type-IV secretion system (T4SS) effector D-glycero-beta-D-manno-heptose-1,7-bisphosphate (betaHBP) and protein kinase C (PKC) as a new c-Abl kinase. Threonine 56-65 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 248-253 19643477-4 2010 Those effects are at least partly conditional upon the enhanced nuclear accumulation of p145 c-ABL through events encompassing post-translational modifications of p145 c-ABL (Thr(735) phosphorylation) precluding its nuclear export and of 14-3-3 sigma (Ser(186) phosphorylation by c-Jun N-terminal kinase [JNK]) promoting p145 c-ABL nuclear re-import. Threonine 175-178 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 93-98 24480037-7 2014 These peptides contained either multiple proline residues or serine/threonine-proline pairs and showed a confirmed binding preference for BCR/ABL+ fibroblasts. Threonine 68-77 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 138-145 25944899-8 2015 These data demonstrate a new mechanism for the induction of DNA damage-induced apoptosis by c-Abl and illustrate network interactions between serine/threonine and tyrosine kinases that dictate cell fate. Threonine 149-158 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 92-97 23318434-5 2013 On one hand, Abl indirectly enhanced phosphorylation of Myc on Ser 62 and Thr 58, its association with Pin1 and p300 and its acetylation by p300. Threonine 74-77 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 13-16 19643477-4 2010 Those effects are at least partly conditional upon the enhanced nuclear accumulation of p145 c-ABL through events encompassing post-translational modifications of p145 c-ABL (Thr(735) phosphorylation) precluding its nuclear export and of 14-3-3 sigma (Ser(186) phosphorylation by c-Jun N-terminal kinase [JNK]) promoting p145 c-ABL nuclear re-import. Threonine 175-178 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 168-173 19643477-4 2010 Those effects are at least partly conditional upon the enhanced nuclear accumulation of p145 c-ABL through events encompassing post-translational modifications of p145 c-ABL (Thr(735) phosphorylation) precluding its nuclear export and of 14-3-3 sigma (Ser(186) phosphorylation by c-Jun N-terminal kinase [JNK]) promoting p145 c-ABL nuclear re-import. Threonine 175-178 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 168-173 17475908-3 2007 In fact, high levels of p210-BCR/ABL are required for enhanced hnRNP-E2 expression, which depends on phosphorylation of hnRNP-E2 serines 173, 189, and 272 and threonine 213 by the BCR/ABL-activated MAPK(ERK1/2). Threonine 159-168 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 33-36 17804707-6 2007 The cocrystal structure of T315I Abl kinase domain provides the structural basis for this activity: the inhibitor associates with an active conformation of the kinase domain in the ATP-binding pocket and lacks the steric hindrance imposed by the substitution of threonine by isoleucine. Threonine 262-271 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 33-36 17475908-3 2007 In fact, high levels of p210-BCR/ABL are required for enhanced hnRNP-E2 expression, which depends on phosphorylation of hnRNP-E2 serines 173, 189, and 272 and threonine 213 by the BCR/ABL-activated MAPK(ERK1/2). Threonine 159-168 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 24-36 17475908-4 2007 Serine/threonine to alanine substitution abolishes hnRNP-E2 phosphorylation and markedly decreases its stability in BCR/ABL-expressing myeloid precursors. Threonine 7-16 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 116-123 17318191-1 2007 Self-renewal of Bcr-Abl(+) chronic myeloid leukemia (CML) cells is sustained by a nuclear activated serine/threonine-(S/T) unphosphorylated beta-catenin. Threonine 107-116 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 16-23 16888623-5 2006 Binding of MUC1 to c-Abl attenuates phosphorylation of c-Abl on Thr-735 and the interaction between c-Abl and cytosolic 14-3-3. Threonine 64-67 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 19-24 17382017-4 2007 One of the more common mutations results from the substitution of isoleucine for threonine at Abl amino acid position 351, known as the T315I mutation. Threonine 81-90 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 94-97 16888623-5 2006 Binding of MUC1 to c-Abl attenuates phosphorylation of c-Abl on Thr-735 and the interaction between c-Abl and cytosolic 14-3-3. Threonine 64-67 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 55-60 16888623-6 2006 We also show that expression of MUC1 with a mutation at Tyr-60 (i) disrupts the interaction between MUC1 and c-Abl, (ii) relieves the MUC1-induced block of c-Abl phosphorylation on Thr-735 and binding to 14-3-3, and (iii) attenuates the MUC1 antiapoptotic function. Threonine 181-184 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 109-114 16888623-6 2006 We also show that expression of MUC1 with a mutation at Tyr-60 (i) disrupts the interaction between MUC1 and c-Abl, (ii) relieves the MUC1-induced block of c-Abl phosphorylation on Thr-735 and binding to 14-3-3, and (iii) attenuates the MUC1 antiapoptotic function. Threonine 181-184 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 156-161 15696159-5 2005 Phosphorylation of c-Abl on Thr 735 functions as a site for direct binding to 14-3-3 proteins. Threonine 28-31 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 19-24 15632178-4 2005 Aspartic acid substitution of Thr(566), which is phosphorylated in mitotic or okadaic acid-treated cells, is sufficient to abolish F-actin-mediated inhibition and to maintain Abl activity despite cell detachment. Threonine 30-33 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 175-178 8227078-13 1993 For v-Abl, the presence of threonine at any position in the YMXM motif caused a reduction in catalytic efficiency. Threonine 27-36 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 4-9 12149456-2 2002 Mutations of Thr-315 in the Abl kinase domain to Ile (T315I) were previously described in STI-571-resistant patients and likely cause resistance from steric interference with drug binding. Threonine 13-16 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 28-31 12077114-3 2002 Co-crystallization studies of Abl kinase and an STI571-related compound identify specific amino acid residues as critical to STI571 binding, one of which, T315, has been characterized as an acquired Thr to Ile mutation in relapsed patients. Threonine 199-202 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 30-33 11840343-4 2002 Here, we present evidence that c-Abl induces the phosphorylation of p73 in threonine residues adjacent to prolines, and that the p38 MAP kinase pathway mediates this response. Threonine 75-84 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 31-36 33419251-4 2020 Here, we presented a 77-year-old male with a diagnosis of Ph positive ALL resistant to ponatinib and carrying a rare threonine to leucine (T315L) mutation on BCR-ABL1 gene. Threonine 117-126 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 162-166