PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23104469-6 2013 The ORF3 protein interacts with the tumor susceptibility gene 101, a critical cellular protein required for the budding of enveloped viruses, through the Pro, Ser, Ala, and Pro (PSAP) motif in infected cells; ORF3 is co-localized with multivesicular bodies (MVBs) in the cytoplasm of infected cells, thus suggesting that HEV requires the MVB pathway for the egress of virus particles. Proline 154-157 ankyrin repeat, SAM and basic leucine zipper domain containing 1 Homo sapiens 4-8 31753030-10 2019 Analysis of the amino acid sequence of ORF3 indicated two hydrophobic domains (HD) and single conserved proline-rich domain (PRD) PREPSAPP (PXXPXXPP) with a single PSAP motif found in C-terminal. Proline 104-111 ankyrin repeat, SAM and basic leucine zipper domain containing 1 Homo sapiens 39-43 29471051-8 2018 ORF3 mutants with proline-to-leucine mutations at amino acids (aa) 93, 96 and/or 98 in ORF3 were constructed and transfected into PLC/PRF/5 cells. Proline 18-25 ankyrin repeat, SAM and basic leucine zipper domain containing 1 Homo sapiens 0-4 29471051-10 2018 In conclusion, the ORF3 protein, especially its proline residues at aa 93 and 96, is essential for the release of membrane-associated ratHEV particles, and ORF4 is unnecessary for the replication of ratHEV. Proline 48-55 ankyrin repeat, SAM and basic leucine zipper domain containing 1 Homo sapiens 19-23 23104469-6 2013 The ORF3 protein interacts with the tumor susceptibility gene 101, a critical cellular protein required for the budding of enveloped viruses, through the Pro, Ser, Ala, and Pro (PSAP) motif in infected cells; ORF3 is co-localized with multivesicular bodies (MVBs) in the cytoplasm of infected cells, thus suggesting that HEV requires the MVB pathway for the egress of virus particles. Proline 154-157 ankyrin repeat, SAM and basic leucine zipper domain containing 1 Homo sapiens 209-213 20610720-2 2010 Virus egress from cells depended on open reading frame 3 (ORF3) protein, and a proline-rich sequence in ORF3 was important for egress from cultured cells and for infection of macaques. Proline 79-86 ankyrin repeat, SAM and basic leucine zipper domain containing 1 Homo sapiens 104-108