PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33975938-4	2021	Here, we show that this RBD conjugated to each of two carrier proteins elicited more potent neutralizing responses in immunized rodents than did a similarly conjugated proline-stabilized S-protein ectodomain.	Proline	168-175	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	187-188	
35575289-7	2022	Mutations at the spike residue P681 in several strains, such P681R in the Delta strain, resulted in the disruption of a proline-directed kinase phosphorylation motif at the S1/S2 site, which may lessen the impact of phosphorylation for these variants.	Proline	120-127	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	17-22	
32995773-5	2021	S2GDeltaHR2 elicited two-fold-higher NAb titers than the proline-capped spike (S2P), while S2GDeltaHR2 SApNPs derived from multilayered E2p and I3-01v9 60-mers elicited up to 10-fold higher NAb titers.	Proline	57-64	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	72-77	
33236008-4	2020	Here we show that this RBD conjugated to each of two carrier proteins elicited more potent neutralizing responses in immunized rodents than did a similarly conjugated proline-stabilized S-protein ectodomain.	Proline	167-174	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	186-187	
34611365-3	2021	We recently developed a prefusion-stabilized spike variant, termed HexaPro for six stabilizing proline substitutions, that can be expressed with a yield of >30 mg/L in ExpiCHO cells.	Proline	95-102	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	45-50	
34461095-2	2021	Here, we demonstrate that the prefusion-stabilized two-proline "S2P" spike -widely employed for laboratory work and clinical studies- unfolds when stored at 4  C, physiological pH, as observed by electron microscopy (EM) and differential scanning calorimetry, but that its trimeric, native-like conformation can be reacquired by low pH treatment.	Proline	55-62	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	69-74	
33653892-4	2021	Exchange of K986 and V987 for prolines has been shown to stabilize the trimers of SARS-CoV-1 and the Middle East respiratory syndrome coronavirus spike proteins.	Proline	30-38	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	146-151	
34717971-3	2022	The latest expression-enhanced version of the spike incorporates six proline substitutions to stabilize the prefusion conformation (termed SARS-CoV-2 S HexaPro).	Proline	69-76	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	46-51	
34987509-7	2021	We developed an intranasal COVID-19 subunit vaccine, based on a recombinant, six-proline-stabilized, D614G spike protein (mC-Spike) of SARS-CoV-2 linked via the LPS-binding peptide sequence mCramp (mC) to outer membrane vesicles (OMVs) from Neisseria meningitidis.	Proline	81-88	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	107-112	
35231586-0	2022	Addition of arginine hydrochloride and proline to the culture medium enhances recombinant protein expression in Brevibacillus choshinensis: The case of RBD of SARS-CoV-2 spike protein and its antibody.	Proline	39-46	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	170-175