PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15517380-1 2005 UNLABELLED: Delta1-pyrroline-5-carboxylate synthase (P5CS) catalyses the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine. Proline 170-177 aldehyde dehydrogenase 18 family member A1 Homo sapiens 18-51 15517380-1 2005 UNLABELLED: Delta1-pyrroline-5-carboxylate synthase (P5CS) catalyses the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine. Proline 170-177 aldehyde dehydrogenase 18 family member A1 Homo sapiens 53-57 11092761-0 2000 Hyperammonemia with reduced ornithine, citrulline, arginine and proline: a new inborn error caused by a mutation in the gene encoding delta(1)-pyrroline-5-carboxylate synthase. Proline 64-71 aldehyde dehydrogenase 18 family member A1 Homo sapiens 134-175 11092761-1 2000 delta(1)-pyrroline-5-carboxylate synthase (P5CS), a bifunctional ATP- and NADPH-dependent mitochondrial enzyme, catalyzes the reduction of glutamate to delta(1)-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine. Proline 225-232 aldehyde dehydrogenase 18 family member A1 Homo sapiens 0-41 11092761-1 2000 delta(1)-pyrroline-5-carboxylate synthase (P5CS), a bifunctional ATP- and NADPH-dependent mitochondrial enzyme, catalyzes the reduction of glutamate to delta(1)-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine. Proline 225-232 aldehyde dehydrogenase 18 family member A1 Homo sapiens 43-47 10037775-2 1999 Delta1-Pyrroline-5-carboxylate synthase (P5CS; EC not assigned), a mitochondrial inner membrane, ATP- and NADPH-dependent, bifunctional enzyme, catalyzes the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline and ornithine. Proline 263-270 aldehyde dehydrogenase 18 family member A1 Homo sapiens 0-39 10037775-2 1999 Delta1-Pyrroline-5-carboxylate synthase (P5CS; EC not assigned), a mitochondrial inner membrane, ATP- and NADPH-dependent, bifunctional enzyme, catalyzes the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline and ornithine. Proline 263-270 aldehyde dehydrogenase 18 family member A1 Homo sapiens 41-45 10037775-7 1999 To confirm the identity of the putative P5CS cDNAs, we expressed both human forms in gamma-glutamyl kinase- and gamma-glutamyl phosphate reductase-deficient strains of Saccharomyces cerevisiae and showed that they conferred the proline prototrophy. Proline 228-235 aldehyde dehydrogenase 18 family member A1 Homo sapiens 40-44 9622938-1 1998 delta 1-pyrroline 5-carboxylate synthetase (P5C synthetase) catalyzes the ATP and the NAD(P)H-dependent conversion of L-glutamate to glutamate semialdehyde (GSA) which is the metabolic precursor for proline biosynthesis. Proline 199-206 aldehyde dehydrogenase 18 family member A1 Homo sapiens 0-42 8761662-0 1996 Database cloning human delta 1-pyrroline-5-carboxylate synthetase (P5CS) cDNA: a bifunctional enzyme catalyzing the first 2 steps in proline biosynthesis. Proline 133-140 aldehyde dehydrogenase 18 family member A1 Homo sapiens 23-65 8761662-0 1996 Database cloning human delta 1-pyrroline-5-carboxylate synthetase (P5CS) cDNA: a bifunctional enzyme catalyzing the first 2 steps in proline biosynthesis. Proline 133-140 aldehyde dehydrogenase 18 family member A1 Homo sapiens 67-71 8761662-1 1996 delta 1-pyrroline-5-carboxylate synthetase (P5CS) catalyzes the ATP and the NAD(P)H-dependent conversion of L-glutamate to glutamic gamma-semialdehyde (GSA) which is the metabolic precursor for proline biosynthesis. Proline 194-201 aldehyde dehydrogenase 18 family member A1 Homo sapiens 0-42 8761662-1 1996 delta 1-pyrroline-5-carboxylate synthetase (P5CS) catalyzes the ATP and the NAD(P)H-dependent conversion of L-glutamate to glutamic gamma-semialdehyde (GSA) which is the metabolic precursor for proline biosynthesis. Proline 194-201 aldehyde dehydrogenase 18 family member A1 Homo sapiens 44-48 8761662-5 1996 The phenotypic features for deficiency of P5CS include joint hyperlaxity, skin hyperelasticity, cataract and mental retardation with hyperammonemia and low plasma levels of proline, citrulline and ornithine. Proline 173-180 aldehyde dehydrogenase 18 family member A1 Homo sapiens 42-46 32798076-1 2021 BACKGROUND: The ALDH18A1 gene is located at 10q24.1 and encodes delta-1-pyrroline-5-carboxylate synthetase (P5CS), a mitochondrial bifunctional enzyme that catalyzes the first two steps in de novo biosynthesis of proline, ornithine, citrulline, and arginine. Proline 213-220 aldehyde dehydrogenase 18 family member A1 Homo sapiens 16-24 32798076-1 2021 BACKGROUND: The ALDH18A1 gene is located at 10q24.1 and encodes delta-1-pyrroline-5-carboxylate synthetase (P5CS), a mitochondrial bifunctional enzyme that catalyzes the first two steps in de novo biosynthesis of proline, ornithine, citrulline, and arginine. Proline 213-220 aldehyde dehydrogenase 18 family member A1 Homo sapiens 64-106 32798076-1 2021 BACKGROUND: The ALDH18A1 gene is located at 10q24.1 and encodes delta-1-pyrroline-5-carboxylate synthetase (P5CS), a mitochondrial bifunctional enzyme that catalyzes the first two steps in de novo biosynthesis of proline, ornithine, citrulline, and arginine. Proline 213-220 aldehyde dehydrogenase 18 family member A1 Homo sapiens 108-112 34390414-5 2021 Proline can be synthesized by aldehyde dehydrogenase family 18 member A1 (ALDH18A1) and delta1-pyrroline-5-carboxylate reductase (PYCR), up-regulating ALDH18A1 and PYCR can promote the proliferation and invasion of cancer cells. Proline 0-7 aldehyde dehydrogenase 18 family member A1 Homo sapiens 30-72 34390414-5 2021 Proline can be synthesized by aldehyde dehydrogenase family 18 member A1 (ALDH18A1) and delta1-pyrroline-5-carboxylate reductase (PYCR), up-regulating ALDH18A1 and PYCR can promote the proliferation and invasion of cancer cells. Proline 0-7 aldehyde dehydrogenase 18 family member A1 Homo sapiens 74-82 34390414-5 2021 Proline can be synthesized by aldehyde dehydrogenase family 18 member A1 (ALDH18A1) and delta1-pyrroline-5-carboxylate reductase (PYCR), up-regulating ALDH18A1 and PYCR can promote the proliferation and invasion of cancer cells. Proline 0-7 aldehyde dehydrogenase 18 family member A1 Homo sapiens 151-159 35453378-5 2022 Under drought stress, wheat seedlings responded in proline accumulation that was correlated with the P5CS gene expression. Proline 51-58 aldehyde dehydrogenase 18 family member A1 Homo sapiens 101-105 35286254-1 2022 The bifunctional enzyme Delta1-pyrroline-5-carboxylate synthase (P5CS) is vital to the synthesis of proline and ornithine, playing an essential role in human health and agriculture. Proline 100-107 aldehyde dehydrogenase 18 family member A1 Homo sapiens 24-63 35286254-1 2022 The bifunctional enzyme Delta1-pyrroline-5-carboxylate synthase (P5CS) is vital to the synthesis of proline and ornithine, playing an essential role in human health and agriculture. Proline 100-107 aldehyde dehydrogenase 18 family member A1 Homo sapiens 65-69 6115302-2 1981 Using a radioisotopic assay, we have studied the regulation by ornithine of delta 1-pyrroline-5-carboxylate synthase, the enzyme that catalyzes the first step of proline biosynthesis from glutamic acid. Proline 162-169 aldehyde dehydrogenase 18 family member A1 Homo sapiens 76-116 33646427-8 2021 Two of the enzymes in the proline biosynthetic pathway, pyrroline-5-carboxylate reductase (PYCR1) and Aldehyde Dehydrogenase 18 Family Member A1 (ALDH18A1), are upregulated in liver cancer of both human and animal models, while proline catabolic enzymes, such as proline dehydrogenase (PRODH) are downregulated. Proline 26-33 aldehyde dehydrogenase 18 family member A1 Homo sapiens 102-144 33646427-8 2021 Two of the enzymes in the proline biosynthetic pathway, pyrroline-5-carboxylate reductase (PYCR1) and Aldehyde Dehydrogenase 18 Family Member A1 (ALDH18A1), are upregulated in liver cancer of both human and animal models, while proline catabolic enzymes, such as proline dehydrogenase (PRODH) are downregulated. Proline 26-33 aldehyde dehydrogenase 18 family member A1 Homo sapiens 146-154 33646427-8 2021 Two of the enzymes in the proline biosynthetic pathway, pyrroline-5-carboxylate reductase (PYCR1) and Aldehyde Dehydrogenase 18 Family Member A1 (ALDH18A1), are upregulated in liver cancer of both human and animal models, while proline catabolic enzymes, such as proline dehydrogenase (PRODH) are downregulated. Proline 228-235 aldehyde dehydrogenase 18 family member A1 Homo sapiens 102-144 33646427-8 2021 Two of the enzymes in the proline biosynthetic pathway, pyrroline-5-carboxylate reductase (PYCR1) and Aldehyde Dehydrogenase 18 Family Member A1 (ALDH18A1), are upregulated in liver cancer of both human and animal models, while proline catabolic enzymes, such as proline dehydrogenase (PRODH) are downregulated. Proline 228-235 aldehyde dehydrogenase 18 family member A1 Homo sapiens 146-154 33465163-9 2021 MYCN-cluster cases showed high expression of ALDH18A1, encoding P5CS related to proline production. Proline 80-87 aldehyde dehydrogenase 18 family member A1 Homo sapiens 45-53 33465163-9 2021 MYCN-cluster cases showed high expression of ALDH18A1, encoding P5CS related to proline production. Proline 80-87 aldehyde dehydrogenase 18 family member A1 Homo sapiens 64-68 32770108-1 2021 Pyrroline-5-carboxylate synthase (P5CS) catalyzes the synthesis of pyrroline-5-carboxylate (P5C), a key precursor for the synthesis of proline and ornithine. Proline 135-142 aldehyde dehydrogenase 18 family member A1 Homo sapiens 0-32 32770108-1 2021 Pyrroline-5-carboxylate synthase (P5CS) catalyzes the synthesis of pyrroline-5-carboxylate (P5C), a key precursor for the synthesis of proline and ornithine. Proline 135-142 aldehyde dehydrogenase 18 family member A1 Homo sapiens 34-38 32516727-10 2020 Also, increased total soluble carbohydrates, cysteine, and Pro accumulation with increased Pro synthesizing enzyme (Delta1-pyrroline-5-carboxylate synthetase (P5CS) and decreased Pro degrading enzyme (proline dehydrogenase) in Mel + Ca2+ treated plants conferred As toxicity tolerance. Proline 59-62 aldehyde dehydrogenase 18 family member A1 Homo sapiens 122-157 32960509-4 2020 Supervised analysis identified two proteins of proline biosynthesis pathway, PYCR1 and ALDH18A1, that were significantly associated with resistance to treatment based on pattern dominance. Proline 47-54 aldehyde dehydrogenase 18 family member A1 Homo sapiens 87-95 32637352-2 2020 P5CS is involved in proline biosynthesis and targeting ALDH18A1 has previously been shown to inhibit melanoma development by decreasing intracellular proline levels to increase the phosphorylation of eIF2alpha mediated by GCN2, which then impairs mRNA translation. Proline 20-27 aldehyde dehydrogenase 18 family member A1 Homo sapiens 0-4 32637352-2 2020 P5CS is involved in proline biosynthesis and targeting ALDH18A1 has previously been shown to inhibit melanoma development by decreasing intracellular proline levels to increase the phosphorylation of eIF2alpha mediated by GCN2, which then impairs mRNA translation. Proline 150-157 aldehyde dehydrogenase 18 family member A1 Homo sapiens 0-4 32637352-2 2020 P5CS is involved in proline biosynthesis and targeting ALDH18A1 has previously been shown to inhibit melanoma development by decreasing intracellular proline levels to increase the phosphorylation of eIF2alpha mediated by GCN2, which then impairs mRNA translation. Proline 150-157 aldehyde dehydrogenase 18 family member A1 Homo sapiens 55-63 30973753-6 2019 PSAT1 is required for de novo glycine production while ALDH18A1/P5CS is required for de novo proline production. Proline 93-100 aldehyde dehydrogenase 18 family member A1 Homo sapiens 55-63 30973753-6 2019 PSAT1 is required for de novo glycine production while ALDH18A1/P5CS is required for de novo proline production. Proline 93-100 aldehyde dehydrogenase 18 family member A1 Homo sapiens 64-68 30853934-5 2019 P5CS is a critical enzyme in the conversion of glutamate to pyrroline-5-carboxylate, an intermediate that enters in the proline biosynthesis and that is connected with the urea cycle. Proline 120-127 aldehyde dehydrogenase 18 family member A1 Homo sapiens 0-4 29084919-7 2018 Moreover, we demonstrated that hypoxia activated proline biosynthesis via upregulation of ALDH18A1, subsequently leading to accumulation of hydroxyproline via attenuated PRODH2 activity. Proline 49-56 aldehyde dehydrogenase 18 family member A1 Homo sapiens 90-98 28510193-2 2017 In plants, P5CS proteins are key enzymes that catalyzed the rate-limiting steps of proline synthesis, and proline is a well-known osmoprotectant that is closely related to abiotic stress tolerance. Proline 83-90 aldehyde dehydrogenase 18 family member A1 Homo sapiens 11-15 28510193-2 2017 In plants, P5CS proteins are key enzymes that catalyzed the rate-limiting steps of proline synthesis, and proline is a well-known osmoprotectant that is closely related to abiotic stress tolerance. Proline 106-113 aldehyde dehydrogenase 18 family member A1 Homo sapiens 11-15 28510193-9 2017 However, there should be other P5CS homologues in the lily genome, and some of them could be highly stress-induced and more important for proline accumulation. Proline 138-145 aldehyde dehydrogenase 18 family member A1 Homo sapiens 31-35 28510193-10 2017 Future studies on P5CS family genes would be of great importance to proline-related stress tolerance in lily. Proline 68-75 aldehyde dehydrogenase 18 family member A1 Homo sapiens 18-22 26829900-9 2016 ALDH18A1 encodes Delta(1)-pyrroline-5-carboxylate synthase, which is related to the biosynthesis of ornithine, citrulline, arginine, and proline. Proline 137-144 aldehyde dehydrogenase 18 family member A1 Homo sapiens 0-8 26829900-9 2016 ALDH18A1 encodes Delta(1)-pyrroline-5-carboxylate synthase, which is related to the biosynthesis of ornithine, citrulline, arginine, and proline. Proline 137-144 aldehyde dehydrogenase 18 family member A1 Homo sapiens 17-58 26082174-4 2015 Therefore, an RNAi screen of a kinase library was undertaken, identifying aldehyde dehydrogenase 18 family, member A1 (ALDH18A1) as a critically important gene in regulating melanoma cell growth through proline biosynthesis. Proline 203-210 aldehyde dehydrogenase 18 family member A1 Homo sapiens 74-117 26082174-4 2015 Therefore, an RNAi screen of a kinase library was undertaken, identifying aldehyde dehydrogenase 18 family, member A1 (ALDH18A1) as a critically important gene in regulating melanoma cell growth through proline biosynthesis. Proline 203-210 aldehyde dehydrogenase 18 family member A1 Homo sapiens 119-127 26082174-7 2015 Mechanistically, targeting ALDH18A1 activated the serine/threonine protein kinase GCN2 (general control nonderepressible 2) to inhibit protein synthesis, which could be reversed with proline supplementation. Proline 183-190 aldehyde dehydrogenase 18 family member A1 Homo sapiens 27-35 26082174-8 2015 Thus, targeting ALDH18A1 in melanoma can be used to disrupt proline biosynthesis to limit cell metabolism thereby increasing the cellular doubling time mediated through the GCN2 pathway. Proline 60-67 aldehyde dehydrogenase 18 family member A1 Homo sapiens 16-24 26320891-2 2015 They are caused by biallelic mutations in PYCR1 or ALDH18A1, encoding pyrroline-5-carboxylate reductase 1 and pyrroline-5-carboxylate synthase (P5CS), respectively, which both operate in the mitochondrial proline cycle. Proline 205-212 aldehyde dehydrogenase 18 family member A1 Homo sapiens 51-59 26320891-2 2015 They are caused by biallelic mutations in PYCR1 or ALDH18A1, encoding pyrroline-5-carboxylate reductase 1 and pyrroline-5-carboxylate synthase (P5CS), respectively, which both operate in the mitochondrial proline cycle. Proline 205-212 aldehyde dehydrogenase 18 family member A1 Homo sapiens 110-142 26320891-2 2015 They are caused by biallelic mutations in PYCR1 or ALDH18A1, encoding pyrroline-5-carboxylate reductase 1 and pyrroline-5-carboxylate synthase (P5CS), respectively, which both operate in the mitochondrial proline cycle. Proline 205-212 aldehyde dehydrogenase 18 family member A1 Homo sapiens 144-148 26320891-8 2015 Furthermore, we found that the mutant cells had a reduced P5CS enzymatic activity leading to a delayed proline accumulation. Proline 103-110 aldehyde dehydrogenase 18 family member A1 Homo sapiens 58-62 26026163-3 2015 ALDH18A1 encodes delta-1-pyrroline-5-carboxylate synthase (P5CS), an enzyme that catalyses the first and common step of proline and ornithine biosynthesis from glutamate. Proline 120-127 aldehyde dehydrogenase 18 family member A1 Homo sapiens 0-8 26026163-3 2015 ALDH18A1 encodes delta-1-pyrroline-5-carboxylate synthase (P5CS), an enzyme that catalyses the first and common step of proline and ornithine biosynthesis from glutamate. Proline 120-127 aldehyde dehydrogenase 18 family member A1 Homo sapiens 17-57 26026163-3 2015 ALDH18A1 encodes delta-1-pyrroline-5-carboxylate synthase (P5CS), an enzyme that catalyses the first and common step of proline and ornithine biosynthesis from glutamate. Proline 120-127 aldehyde dehydrogenase 18 family member A1 Homo sapiens 59-63 26026163-6 2015 Low levels of plasma ornithine, citrulline, arginine and proline in four individuals from two families suggested P5CS deficiency. Proline 57-64 aldehyde dehydrogenase 18 family member A1 Homo sapiens 113-117 24068435-0 2013 Molecular evolution of plant P5CS gene involved in proline biosynthesis. Proline 51-58 aldehyde dehydrogenase 18 family member A1 Homo sapiens 29-33 24068435-1 2013 The P5CS ({Delta} 1-Pyrroline-5-Carboxylate Synthetase) gene encodes for a bifunctional enzyme that catalyzes the rate limiting reaction in proline biosynthesis in living organisms. Proline 140-147 aldehyde dehydrogenase 18 family member A1 Homo sapiens 4-8 24068435-1 2013 The P5CS ({Delta} 1-Pyrroline-5-Carboxylate Synthetase) gene encodes for a bifunctional enzyme that catalyzes the rate limiting reaction in proline biosynthesis in living organisms. Proline 140-147 aldehyde dehydrogenase 18 family member A1 Homo sapiens 11-54 24068435-3 2013 The proline biosynthetic genes, especially, P5CS is commonly used in metabolic engineering for proline overproduction conferring stress tolerance in plants. Proline 4-11 aldehyde dehydrogenase 18 family member A1 Homo sapiens 44-48 24068435-3 2013 The proline biosynthetic genes, especially, P5CS is commonly used in metabolic engineering for proline overproduction conferring stress tolerance in plants. Proline 95-102 aldehyde dehydrogenase 18 family member A1 Homo sapiens 44-48 23041351-7 2013 Moreover, transcriptional analysis of polyamine and proline metabolism genes (P5CS, P5CR, ADC, SPMS, SPDS, SAMDC, PAO, DAO) further supported the obtained data and revealed a complex SNP concentration-, time-, and developmental stage-dependent mechanism controlling endogenous proline and polyamine metabolite production. Proline 52-59 aldehyde dehydrogenase 18 family member A1 Homo sapiens 78-82 23041351-7 2013 Moreover, transcriptional analysis of polyamine and proline metabolism genes (P5CS, P5CR, ADC, SPMS, SPDS, SAMDC, PAO, DAO) further supported the obtained data and revealed a complex SNP concentration-, time-, and developmental stage-dependent mechanism controlling endogenous proline and polyamine metabolite production. Proline 277-284 aldehyde dehydrogenase 18 family member A1 Homo sapiens 78-82 22170564-1 2012 Delta(1)-Pyrroline-5-carboxylate synthetase (P5CS) catalyzes the first two steps of ornithine/proline biosynthesis. Proline 94-101 aldehyde dehydrogenase 18 family member A1 Homo sapiens 0-43 22170564-1 2012 Delta(1)-Pyrroline-5-carboxylate synthetase (P5CS) catalyzes the first two steps of ornithine/proline biosynthesis. Proline 94-101 aldehyde dehydrogenase 18 family member A1 Homo sapiens 45-49 22170564-3 2012 Only one family exhibited metabolic changes consistent with P5CS deficiency (low proline/ornithine/citrulline/arginine; fasting hyperammonemia). Proline 81-88 aldehyde dehydrogenase 18 family member A1 Homo sapiens 60-64 20387057-2 2010 The Delta(1)-pyrroline-5-carboxylate synthetase catalyzes the first committed step and the rate-limiting step for proline biosynthesis in both plants and mammals. Proline 114-121 aldehyde dehydrogenase 18 family member A1 Homo sapiens 4-47 18401542-1 2008 Mammalian Delta(1)-pyrroline-5-carboxylate synthase (P5CS) is a bifunctional ATP- and NAD(P)H-dependent mitochondrial enzyme that catalyzes the coupled phosphorylation and reduction-conversion of L: -glutamate to P5C, a pivotal step in the biosynthesis of L: -proline, L: -ornithine and L: -arginine. Proline 256-267 aldehyde dehydrogenase 18 family member A1 Homo sapiens 10-51 18401542-1 2008 Mammalian Delta(1)-pyrroline-5-carboxylate synthase (P5CS) is a bifunctional ATP- and NAD(P)H-dependent mitochondrial enzyme that catalyzes the coupled phosphorylation and reduction-conversion of L: -glutamate to P5C, a pivotal step in the biosynthesis of L: -proline, L: -ornithine and L: -arginine. Proline 256-267 aldehyde dehydrogenase 18 family member A1 Homo sapiens 53-57 18478038-8 2008 In an in vivo assay of flux through this metabolic pathway using dermal fibroblasts obtained from an affected individual, proline and ornithine biosynthetic activity of P5CS was not affected by the H784Y substitution. Proline 122-129 aldehyde dehydrogenase 18 family member A1 Homo sapiens 169-173 18036351-6 2008 In contrast, overexpression of the proline biosynthetic enzymes Delta(1)-pyrroline-5-carboxylate (P5C) synthetase (P5CS) and P5C reductase (P5CR) resulted in 2-fold higher proline content, significantly lower ROS levels, and increased cell survival relative to control cells. Proline 35-42 aldehyde dehydrogenase 18 family member A1 Homo sapiens 115-119 18036351-6 2008 In contrast, overexpression of the proline biosynthetic enzymes Delta(1)-pyrroline-5-carboxylate (P5C) synthetase (P5CS) and P5C reductase (P5CR) resulted in 2-fold higher proline content, significantly lower ROS levels, and increased cell survival relative to control cells. Proline 172-179 aldehyde dehydrogenase 18 family member A1 Homo sapiens 115-119 18036351-7 2008 In different mammalian cell lines exposed to physiological H(2)O(2) levels, increased endogenous P5CS and P5CR expression was observed, indicating that upregulation of proline biosynthesis is an oxidative stress response. Proline 168-175 aldehyde dehydrogenase 18 family member A1 Homo sapiens 97-101