PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31473186-2 2019 Both metformin and canagliflozin indirectly activate AMPK by inhibiting mitochondrial function, while salsalate is a direct AMPK activator. salicylsalicylic acid 102-111 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 124-128 34425254-0 2021 Salsalate reduces atherosclerosis through AMPKbeta1 in mice. salicylsalicylic acid 0-9 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 42-51 34425254-10 2021 CONCLUSIONS: These data indicate that salsalate suppresses macrophage proliferation and atherosclerosis through an AMPKbeta1-dependent pathways and this may involve the phosphorylation of HMGCR and cholesterol synthesis. salicylsalicylic acid 38-47 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 115-124 23825542-6 2013 Palmitate-induced SeP expression was inhibited by both salsalate and salicylate, which was mediated by AMPK activation, and was blocked by AMPK siRNA or an inhibitor of AMPK. salicylsalicylic acid 55-64 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 103-107 23825542-7 2013 Chromatin immunoprecipitation (ChIP) and electrophoretic mobility shift (EMSA) assay showed that salsalate suppressed SeP expression by AMPK-mediated phosphorylation of FOXO1alpha. salicylsalicylic acid 97-106 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 136-140 23825542-10 2013 Taken together, we found that salsalate and adiponectin ameliorated palmitate-induced IR in hepatocytes via SeP inhibition through the AMPK-FOXO1alpha pathway. salicylsalicylic acid 30-39 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 135-139