PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25795558-7	2015	Furthermore, PA induced a robust neutral sphingomyelinase (nSMase)-mediated sphingomyelin hydrolysis that was involved in PA-augmented IL-6 upregulation.	Sphingomyelins	41-54	interleukin 6	Homo sapiens	135-139	
23921144-8	2013	To further elucidate the regulatory mechanism whereby PA amplifies LPS signal, our studies showed that PA and LPS synergistically increased hydrolysis of sphingomyelin by stimulating acid sphingomyelinase (ASMase) activity, which contributed to a marked increase in ceramide production and IL-6 upregulation.	Sphingomyelins	154-167	interleukin 6	Homo sapiens	290-294	
9466577-5	1998	The objective of this study was to determine whether TNF-alpha activates the sphingomyelin pathway in human synovial fibroblasts (HSF) and the potential role of ceramide in HSF proliferation and apoptosis.	Sphingomyelins	77-90	interleukin 6	Homo sapiens	130-133	
9359864-5	1997	The combination of IL-6+IL-1beta led to increased turnover of sphingomyelin in Hep3B cells.	Sphingomyelins	62-75	interleukin 6	Homo sapiens	19-23	
9359864-7	1997	The ability of C2 and C6 to potentiate the effects of cytokines suggests that the sphingomyelin-ceramide pathway participates in induction of CRP and SAA by IL-6+IL-1beta under these experimental conditions, most likely by transducing the effects of IL-1beta.	Sphingomyelins	82-95	interleukin 6	Homo sapiens	157-161	
8550818-5	1995	We propose that the sphingomyelin pathway is part of the signal transduction cascade leading to IL-6 gene expression in astrocytes, and that this pathway may be involved in IL-6-mediated neurodegenerative processes.	Sphingomyelins	20-33	interleukin 6	Homo sapiens	96-100	
8381666-2	1993	Exposure of cells to 0.1 U/ml of sphingomyelinase led to the degradation of 75, 55 and 40% of the cellular total sphingomyelin mass in human skin fibroblasts (HSF), Chinese hamster lung fibroblasts (CHLF) and rat liver hepatocytes (RLH), respectively.	Sphingomyelins	33-46	interleukin 6	Homo sapiens	159-162	
34608242-7	2021	Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them.	Sphingomyelins	30-43	interleukin 6	Homo sapiens	173-186	
34608242-7	2021	Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them.	Sphingomyelins	30-43	interleukin 6	Homo sapiens	188-192	
34608242-7	2021	Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them.	Sphingomyelins	45-47	interleukin 6	Homo sapiens	173-186	
12732938-8	2003	Total intracellular PL contents were also unchanged; however, IL-6 led to significant changes in PL composition including an increase in phosphatidylethanolamine (PE) and sphingomyelin (SM) and a decrease in phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) ( p<0.05).	Sphingomyelins	171-184	interleukin 6	Homo sapiens	62-66	
12732938-8	2003	Total intracellular PL contents were also unchanged; however, IL-6 led to significant changes in PL composition including an increase in phosphatidylethanolamine (PE) and sphingomyelin (SM) and a decrease in phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) ( p<0.05).	Sphingomyelins	186-188	interleukin 6	Homo sapiens	62-66	
8550818-0	1995	Stimulation of the sphingomyelin pathway induces interleukin-6 gene expression in human astrocytoma cells.	Sphingomyelins	19-32	interleukin 6	Homo sapiens	49-62