PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16879426-3 2006 Sphingomyelin synthase 1 functions by catalyzing the conversion of ceramide and phosphatidylcholine to sphingomyelin and diacylglycerol. Sphingomyelins 103-116 sphingomyelin synthase 1 Mus musculus 0-24 16508036-1 2006 Sphingomyelin synthase 1 (SMS1) and SMS2 are two isoforms of SMS, the last enzyme for sphingomyelin (SM) biosynthesis. Sphingomyelins 86-99 sphingomyelin synthase 1 Mus musculus 0-24 16508036-1 2006 Sphingomyelin synthase 1 (SMS1) and SMS2 are two isoforms of SMS, the last enzyme for sphingomyelin (SM) biosynthesis. Sphingomyelins 86-99 sphingomyelin synthase 1 Mus musculus 26-30 16508036-1 2006 Sphingomyelin synthase 1 (SMS1) and SMS2 are two isoforms of SMS, the last enzyme for sphingomyelin (SM) biosynthesis. Sphingomyelins 26-28 sphingomyelin synthase 1 Mus musculus 0-24 16226406-1 2005 Sphingomyelin synthase 1 (SMS1) is a recently identified 413-residue protein that plays a critical role in sphingolipid metabolism by catalyzing the conversion of ceramide and phosphatidylcholine to sphingomyelin and diacylglycerol (DAG). Sphingomyelins 199-212 sphingomyelin synthase 1 Mus musculus 0-24 16226406-1 2005 Sphingomyelin synthase 1 (SMS1) is a recently identified 413-residue protein that plays a critical role in sphingolipid metabolism by catalyzing the conversion of ceramide and phosphatidylcholine to sphingomyelin and diacylglycerol (DAG). Sphingomyelins 199-212 sphingomyelin synthase 1 Mus musculus 26-30 33545384-3 2021 SM is synthesized by sphingomyelin synthase 1 and 2 (SMS1 and SMS2) which utilizes ceramide and phosphatidylcholine, as two substrates, to produce SM and diacylglyceride. Sphingomyelins 0-2 sphingomyelin synthase 1 Mus musculus 21-51 14976195-7 2004 WR19L/Fas-SM(-) cells expressing SMS1 cDNA (WR19L/Fas-SMS1) restored the resistance against MbetaCD, the accumulation of SM at the plasma membrane, and SM synthesis by transferring phosphocholine from phosphatidylcholine to ceramide. Sphingomyelins 10-12 sphingomyelin synthase 1 Mus musculus 33-37 14976195-7 2004 WR19L/Fas-SM(-) cells expressing SMS1 cDNA (WR19L/Fas-SMS1) restored the resistance against MbetaCD, the accumulation of SM at the plasma membrane, and SM synthesis by transferring phosphocholine from phosphatidylcholine to ceramide. Sphingomyelins 10-12 sphingomyelin synthase 1 Mus musculus 50-58 35230716-2 2022 Sphingomyelin (SM), a sphingolipid synthesized by sphingomyelin synthase (SMS) 1 and 2, is involved in signal transduction via modulation of lipid-raft functions. Sphingomyelins 15-17 sphingomyelin synthase 1 Mus musculus 50-86 33545384-3 2021 SM is synthesized by sphingomyelin synthase 1 and 2 (SMS1 and SMS2) which utilizes ceramide and phosphatidylcholine, as two substrates, to produce SM and diacylglyceride. Sphingomyelins 53-55 sphingomyelin synthase 1 Mus musculus 21-51 34478523-1 2021 Sphingomyelin synthase 1 (SMS1) contributes to the generation of membrane sphingomyelin (SM) and affects SM-mediated physiological functions. Sphingomyelins 74-87 sphingomyelin synthase 1 Mus musculus 0-24 34478523-1 2021 Sphingomyelin synthase 1 (SMS1) contributes to the generation of membrane sphingomyelin (SM) and affects SM-mediated physiological functions. Sphingomyelins 74-87 sphingomyelin synthase 1 Mus musculus 26-30 34478523-1 2021 Sphingomyelin synthase 1 (SMS1) contributes to the generation of membrane sphingomyelin (SM) and affects SM-mediated physiological functions. Sphingomyelins 89-91 sphingomyelin synthase 1 Mus musculus 0-24 34478523-1 2021 Sphingomyelin synthase 1 (SMS1) contributes to the generation of membrane sphingomyelin (SM) and affects SM-mediated physiological functions. Sphingomyelins 89-91 sphingomyelin synthase 1 Mus musculus 26-30 34478523-1 2021 Sphingomyelin synthase 1 (SMS1) contributes to the generation of membrane sphingomyelin (SM) and affects SM-mediated physiological functions. Sphingomyelins 105-107 sphingomyelin synthase 1 Mus musculus 0-24 34478523-1 2021 Sphingomyelin synthase 1 (SMS1) contributes to the generation of membrane sphingomyelin (SM) and affects SM-mediated physiological functions. Sphingomyelins 105-107 sphingomyelin synthase 1 Mus musculus 26-30 34478523-4 2021 Deficiency of SMS1, but not SMS2, prevented SM production and enhanced phosphatidylserine (PS) externalization on the plasma membranes of platelets and megakaryocytes. Sphingomyelins 44-46 sphingomyelin synthase 1 Mus musculus 14-18 34478523-9 2021 Therefore, SM depletion on platelet membrane microdomains due to SMS1 deficiency enhanced PS externalization via a Ca2+ influx through TMEM16F activation, leading to elevated platelet clearance and causing hemostasis dysfunction through thrombocytopenia. Sphingomyelins 11-13 sphingomyelin synthase 1 Mus musculus 65-69 33545384-3 2021 SM is synthesized by sphingomyelin synthase 1 and 2 (SMS1 and SMS2) which utilizes ceramide and phosphatidylcholine, as two substrates, to produce SM and diacylglyceride. Sphingomyelins 0-2 sphingomyelin synthase 1 Mus musculus 53-57 27882938-5 2016 SMPD3 deficiency disrupts homeostasis of sphingomyelin (SM), ceramide (Cer) and diacylglycerol (DAG) in the Golgi SMPD3-SMS1 (SM-synthase1) cycle. Sphingomyelins 0-2 sphingomyelin synthase 1 Mus musculus 120-124 22688512-4 2012 In addition, SMS1/SMS2 double-knockout cells had heightened sensitivity to CXCL12, which was significantly suppressed upon transfection with the SMS1 or SMS2 gene or when they were treated with exogenous sphingomyelin but not when they were treated with the SMS substrate ceramide. Sphingomyelins 204-217 sphingomyelin synthase 1 Mus musculus 13-17 27788151-2 2016 We have generated a transgenic mouse line carrying an insertion in the sphingomyelin synthase gene Sms1, the enzyme which generates sphingomyelin species in the Golgi apparatus. Sphingomyelins 71-84 sphingomyelin synthase 1 Mus musculus 99-103 23593476-1 2013 Sphingomyelin synthase 1 (SMS1) catalyzes the conversion of ceramide to sphingomyelin. Sphingomyelins 72-85 sphingomyelin synthase 1 Mus musculus 0-24 23593476-1 2013 Sphingomyelin synthase 1 (SMS1) catalyzes the conversion of ceramide to sphingomyelin. Sphingomyelins 72-85 sphingomyelin synthase 1 Mus musculus 26-30 21115496-1 2011 Sphingomyelin synthase 1 (SMS1) catalyzes the conversion of ceramide to sphingomyelin. Sphingomyelins 72-85 sphingomyelin synthase 1 Mus musculus 0-24 21115496-1 2011 Sphingomyelin synthase 1 (SMS1) catalyzes the conversion of ceramide to sphingomyelin. Sphingomyelins 72-85 sphingomyelin synthase 1 Mus musculus 26-30