PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23018927-3	2012	Recently, ranolazine was also shown to be an inhibitor of Na(V)1.5 mechanosensitivity.	Ranolazine	10-20	immunoglobulin lambda variable 2-18	Homo sapiens	58-66	
25496128-6	2014	CONCLUSIONS: Taken together, our results demonstrate the importance of Na(V)1.5 in the metastatic colonisation of organs by breast cancer cells and indicate that small molecules interfering with Na(V) activity, such as ranolazine, may represent powerful pharmacological tools to inhibit metastatic development and improve cancer treatments.	Ranolazine	219-229	immunoglobulin lambda variable 2-18	Homo sapiens	71-79	
25496128-4	2014	Furthermore, we demonstrated that ranolazine (50 muM) inhibited Na(V)1.5 currents in breast cancer cells and reduced Na(V)1.5-related cancer cell invasiveness in vitro.	Ranolazine	34-44	immunoglobulin lambda variable 2-18	Homo sapiens	64-72	
25496128-4	2014	Furthermore, we demonstrated that ranolazine (50 muM) inhibited Na(V)1.5 currents in breast cancer cells and reduced Na(V)1.5-related cancer cell invasiveness in vitro.	Ranolazine	34-44	immunoglobulin lambda variable 2-18	Homo sapiens	117-125	
25496128-5	2014	In vivo, the injection of ranolazine (50 mg/kg/day) significantly reduced lung colonisation by Na(V)1.5-expressing human breast cancer cells.	Ranolazine	26-36	immunoglobulin lambda variable 2-18	Homo sapiens	95-103	
22565935-0	2012	Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel Na(v)1.5: a novel mechanism of drug action.	Ranolazine	0-10	immunoglobulin lambda variable 2-18	Homo sapiens	80-88	
22565935-2	2012	Ranolazine is a Na(V)1.5 antagonist with antianginal and antiarrhythmic properties.	Ranolazine	0-10	immunoglobulin lambda variable 2-18	Homo sapiens	16-24	
22565935-9	2012	Block of Na(V)1.5 mechanosensitivity by ranolazine was not due to the known binding site on DIVS6 (F1760).	Ranolazine	40-50	immunoglobulin lambda variable 2-18	Homo sapiens	9-17	
22565935-10	2012	The effect of ranolazine on mechanosensitivity of Na(V)1.5 was approximated by lidocaine.	Ranolazine	14-24	immunoglobulin lambda variable 2-18	Homo sapiens	50-58	
22565935-12	2012	CONCLUSIONS: Ranolazine effectively inhibits mechanosensitivity of Na(V)1.5.	Ranolazine	13-23	immunoglobulin lambda variable 2-18	Homo sapiens	67-75	
22565935-13	2012	The block of Na(V)1.5 mechanosensitivity by ranolazine does not utilize the established binding site and may require bilayer partitioning.	Ranolazine	44-54	immunoglobulin lambda variable 2-18	Homo sapiens	13-21	
22565935-14	2012	Ranolazine block of Na(V)1.5 mechanosensitivity may be relevant in disorders of mechanoelectric dysfunction.	Ranolazine	0-10	immunoglobulin lambda variable 2-18	Homo sapiens	20-28	
19077543-2	2008	Ranolazine, an anti-ischemic drug, has been shown to block cardiac (Na(V)1.5) late sodium current (I(Na)).	Ranolazine	0-10	immunoglobulin lambda variable 2-18	Homo sapiens	68-76