PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2808412-1 1989 The amino acid sequence of the sex steroid-binding protein (SBP or SHBG) of rabbit serum, specific for binding testosterone and 5 alpha-dihydrotestosterone, was determined using a complementary combination of mass spectrometric and Edman degradation techniques. Dihydrotestosterone 128-155 selenium binding protein 1 Homo sapiens 60-63 1907862-1 1991 In heifers, the specific 5 alpha-dihydrotestosterone (5 alpha-DHT) binding to sex steroid-binding protein (SBP) was 53 nM in midluteal phase and was 20% lower (p less than 0.05) in early luteal phase. Dihydrotestosterone 25-52 selenium binding protein 1 Homo sapiens 107-110 1907862-1 1991 In heifers, the specific 5 alpha-dihydrotestosterone (5 alpha-DHT) binding to sex steroid-binding protein (SBP) was 53 nM in midluteal phase and was 20% lower (p less than 0.05) in early luteal phase. Dihydrotestosterone 54-65 selenium binding protein 1 Homo sapiens 107-110 1907862-6 1991 Porcine growth hormone (pGH) and E2 injections increased specific 5 alpha-DHT binding to SBP in both H and L heifers, but the effect depended on diet. Dihydrotestosterone 73-77 selenium binding protein 1 Homo sapiens 89-92 1659891-2 1991 The hormonal regulation studies of hepatic SBP mRNA demonstrate that it is controlled by estradiol, antiestrogen tamoxifen, dihydrotestosterone, triiodothyronine and insulin in a similar way as secreted SBP. Dihydrotestosterone 124-143 selenium binding protein 1 Homo sapiens 43-46 7980944-2 1994 Binding data obtained using charcoal adsorption assay and equilibrium dialysis methods indicates a single protein, named Bufo arenarum sex binding protein (Ba SBP), which binds 5 alpha-dihydrotestosterone (DHT), testosterone (T), and estradiol-17 beta (E2) with high affinity (10(-7) M-1 - 10(8) M-1) and fair capacity (10(-6) M). Dihydrotestosterone 206-209 selenium binding protein 1 Homo sapiens 159-162 1314639-6 1992 Both dihydrotestosterone and estradiol were shown to inhibit the binding of SBP to its specific receptor on neoplastic membranes. Dihydrotestosterone 5-24 selenium binding protein 1 Homo sapiens 76-79 6933505-4 1980 The dog has an unusual Sbp (Kd for dihydrotestosterone, 7.1 nM; for estradiol, 125 nM), and rodents do not have a specific dihydrotestosterone-binding plasma protein. Dihydrotestosterone 35-54 selenium binding protein 1 Homo sapiens 23-26 7197986-4 1981 Parallel measurements of dihydrotestosterone-binding capacity of SBP showed a good correlation between SBP content and biological activity. Dihydrotestosterone 25-44 selenium binding protein 1 Homo sapiens 65-68 7197986-4 1981 Parallel measurements of dihydrotestosterone-binding capacity of SBP showed a good correlation between SBP content and biological activity. Dihydrotestosterone 25-44 selenium binding protein 1 Homo sapiens 103-106 6933505-1 1980 Sex steoid binding plasma protein (Sbp) in man and in monkeys binds the androgens dihydrotestosterone and testosterone and the estrogen estradiol with high affinity (Kd approximately 0.5, 1, and 2 nM, respectively). Dihydrotestosterone 82-101 selenium binding protein 1 Homo sapiens 4-33 6933505-1 1980 Sex steoid binding plasma protein (Sbp) in man and in monkeys binds the androgens dihydrotestosterone and testosterone and the estrogen estradiol with high affinity (Kd approximately 0.5, 1, and 2 nM, respectively). Dihydrotestosterone 82-101 selenium binding protein 1 Homo sapiens 35-38 3331377-7 1987 (3) Dihydrotestosterone (DHT), the most active androgen in many target cells, given at therapeutic dosages to adult males, resulted in a decrease in plasma concentrations of luteinizing hormone (LH) and T, without any significant change in the percent of free T, even though the affinity of DHT for SBP is higher than that of T. This suggests that the main effect of DHT is to inhibit gonadotropin secretion at the central level. Dihydrotestosterone 4-23 selenium binding protein 1 Homo sapiens 299-302 3331377-7 1987 (3) Dihydrotestosterone (DHT), the most active androgen in many target cells, given at therapeutic dosages to adult males, resulted in a decrease in plasma concentrations of luteinizing hormone (LH) and T, without any significant change in the percent of free T, even though the affinity of DHT for SBP is higher than that of T. This suggests that the main effect of DHT is to inhibit gonadotropin secretion at the central level. Dihydrotestosterone 25-28 selenium binding protein 1 Homo sapiens 299-302 3934028-1 1985 Reproductively active female Bufo arenarum possess a serum protein (SBP) that binds testosterone, dihydrotestosterone, and estradiol with high affinity and capacity. Dihydrotestosterone 98-117 selenium binding protein 1 Homo sapiens 68-71 7197818-2 1981 SBP was purified partially and the ability of each of more than 150 steroids to compete with [3H]dihydrotestosterone (17 beta-hydroxy-5 alpha-androstan-3-one) for binding to SBP was assessed. Dihydrotestosterone 93-116 selenium binding protein 1 Homo sapiens 0-3 7197818-2 1981 SBP was purified partially and the ability of each of more than 150 steroids to compete with [3H]dihydrotestosterone (17 beta-hydroxy-5 alpha-androstan-3-one) for binding to SBP was assessed. Dihydrotestosterone 93-116 selenium binding protein 1 Homo sapiens 174-177 7197818-2 1981 SBP was purified partially and the ability of each of more than 150 steroids to compete with [3H]dihydrotestosterone (17 beta-hydroxy-5 alpha-androstan-3-one) for binding to SBP was assessed. Dihydrotestosterone 118-157 selenium binding protein 1 Homo sapiens 0-3 7197818-2 1981 SBP was purified partially and the ability of each of more than 150 steroids to compete with [3H]dihydrotestosterone (17 beta-hydroxy-5 alpha-androstan-3-one) for binding to SBP was assessed. Dihydrotestosterone 118-157 selenium binding protein 1 Homo sapiens 174-177 6766666-1 1980 Several species of primates have sex differences in sex steroid-binding protein (SBP), female adults having higher serum binding capacities (micrograms of dihydrotestosterone bound per deciliter) than male adults, e.g., male humans, 1.28 +/- 0.4; human females, 2.86 +4- 0.9; Macaca nemestrina male animals, 5.62 +/- 1.24; Macaca nemestrina female animals, 11.07 +/- 1.85 (means +/- standard deviations). Dihydrotestosterone 155-174 selenium binding protein 1 Homo sapiens 81-84 59732-12 1976 In addition, SBP altered the metabolism of testosterone: the androstanolone/testosterone ratio in the prostate explants was critically dependent upon the SBP concentration in the superfusion medium. Dihydrotestosterone 61-75 selenium binding protein 1 Homo sapiens 13-16 59732-12 1976 In addition, SBP altered the metabolism of testosterone: the androstanolone/testosterone ratio in the prostate explants was critically dependent upon the SBP concentration in the superfusion medium. Dihydrotestosterone 61-75 selenium binding protein 1 Homo sapiens 154-157 51854-11 1975 The second binding component was attributable, at least in part, to the sex steroid-binding plasma protein (SBP), as indicated by its sedimentation coefficient (congruent to 4 S in low salt medium), its high affinity for androstanolone and androstanediol and its lower affinity for estradiol, and finally, its migration on polyacrylamide gel electrophoresis. Dihydrotestosterone 221-235 selenium binding protein 1 Homo sapiens 76-106 51854-11 1975 The second binding component was attributable, at least in part, to the sex steroid-binding plasma protein (SBP), as indicated by its sedimentation coefficient (congruent to 4 S in low salt medium), its high affinity for androstanolone and androstanediol and its lower affinity for estradiol, and finally, its migration on polyacrylamide gel electrophoresis. Dihydrotestosterone 221-235 selenium binding protein 1 Homo sapiens 108-111 51854-12 1975 In one instance, the concentration of the SBP-like protein in prostate cytosol was measured by equilibrium dialysis, and it was calculated that the binding capacity of the prostate SBP-like component corresponded to 4 pmol of androstanolone/g of prostate, a small (less than 5%) value with regard to SBP concentration in the plasma of the same patient. Dihydrotestosterone 226-240 selenium binding protein 1 Homo sapiens 42-45 51854-12 1975 In one instance, the concentration of the SBP-like protein in prostate cytosol was measured by equilibrium dialysis, and it was calculated that the binding capacity of the prostate SBP-like component corresponded to 4 pmol of androstanolone/g of prostate, a small (less than 5%) value with regard to SBP concentration in the plasma of the same patient. Dihydrotestosterone 226-240 selenium binding protein 1 Homo sapiens 181-184 51854-12 1975 In one instance, the concentration of the SBP-like protein in prostate cytosol was measured by equilibrium dialysis, and it was calculated that the binding capacity of the prostate SBP-like component corresponded to 4 pmol of androstanolone/g of prostate, a small (less than 5%) value with regard to SBP concentration in the plasma of the same patient. Dihydrotestosterone 226-240 selenium binding protein 1 Homo sapiens 181-184 51854-16 1975 In the peak containing the SBP-like protein, the ratio was 0.74, which may suggest that all or part had been exposed to the predominant androstanolone environment inside the prostatic cell. Dihydrotestosterone 136-150 selenium binding protein 1 Homo sapiens 27-30