PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22040886-0 2011 Dihydrotestosterone inhibits interleukin-1alpha or tumor necrosis factor alpha-induced proinflammatory cytokine production via androgen receptor-dependent inhibition of nuclear factor-kappaB activation in rheumatoid fibroblast-like synovial cell line. Dihydrotestosterone 0-19 tumor necrosis factor Homo sapiens 51-78 22040886-5 2011 DHT also inhibited the effects of TNFalpha on the cells overexpressed with AR, indicating that sufficient expression level of functional AR was necessary for the inhibitory effect of DHT on TNFalpha. Dihydrotestosterone 0-3 tumor necrosis factor Homo sapiens 34-42 22040886-5 2011 DHT also inhibited the effects of TNFalpha on the cells overexpressed with AR, indicating that sufficient expression level of functional AR was necessary for the inhibitory effect of DHT on TNFalpha. Dihydrotestosterone 0-3 tumor necrosis factor Homo sapiens 190-198 22040886-5 2011 DHT also inhibited the effects of TNFalpha on the cells overexpressed with AR, indicating that sufficient expression level of functional AR was necessary for the inhibitory effect of DHT on TNFalpha. Dihydrotestosterone 183-186 tumor necrosis factor Homo sapiens 34-42 22040886-5 2011 DHT also inhibited the effects of TNFalpha on the cells overexpressed with AR, indicating that sufficient expression level of functional AR was necessary for the inhibitory effect of DHT on TNFalpha. Dihydrotestosterone 183-186 tumor necrosis factor Homo sapiens 190-198 20043171-7 2010 Upregulation of IL-6 and TNF-alpha in immunohistochemistry, and increase in RNA amplification for IL-6 and TNF-alpha were observed after addition of DHT compared with the control. Dihydrotestosterone 149-152 tumor necrosis factor Homo sapiens 25-34 20043171-7 2010 Upregulation of IL-6 and TNF-alpha in immunohistochemistry, and increase in RNA amplification for IL-6 and TNF-alpha were observed after addition of DHT compared with the control. Dihydrotestosterone 149-152 tumor necrosis factor Homo sapiens 107-116 11918080-3 2002 Tumor necrosis factor-alpha (TNF-alpha) regulates VCAM expression on the endothelium and this effect is enhanced by dihydrotestosterone (DHT). Dihydrotestosterone 116-135 tumor necrosis factor Homo sapiens 0-27 17541168-4 2007 We found that a potent androgen, 5alpha-dihydrotestosterone (DHT) inhibits IL-1alpha mRNA expression induced by TNFalpha and the DHT effect was inhibited by an androgen receptor antagonist, hydroxyflutamide (OHF). Dihydrotestosterone 33-59 tumor necrosis factor Homo sapiens 112-120 17541168-4 2007 We found that a potent androgen, 5alpha-dihydrotestosterone (DHT) inhibits IL-1alpha mRNA expression induced by TNFalpha and the DHT effect was inhibited by an androgen receptor antagonist, hydroxyflutamide (OHF). Dihydrotestosterone 61-64 tumor necrosis factor Homo sapiens 112-120 17541168-5 2007 DHT inhibited the NF-kappaB activation induced by TNFalpha in a manner dependent on the androgen receptor (AR). Dihydrotestosterone 0-3 tumor necrosis factor Homo sapiens 50-58 17541168-6 2007 These results suggest that DHT inhibits the TNFalpha-induced IL-1alpha mRNA expression by inhibiting NF-kappaB activation, and contributes to the gender differences of the disease. Dihydrotestosterone 27-30 tumor necrosis factor Homo sapiens 44-52 16317058-7 2006 RESULTS: Lipopolysaccharide and TNFalpha induced VCAM-1 and ICAM-1 mRNA and protein expression, as detected by real-time quantitative PCR, fluorescence-activated cell sorting, and confocal microscopy, but this effect was inhibited when cells were incubated with DHT. Dihydrotestosterone 262-265 tumor necrosis factor Homo sapiens 32-40 16317058-10 2006 Furthermore, when cells were cotransfected with a Cox-2 promoter or a 3X-NF-kappaB luciferase reporter vector and a plasmid expressing the human androgen receptor, DHT treatment inhibited the increase of the luciferase activity observed with TNFalpha. Dihydrotestosterone 164-167 tumor necrosis factor Homo sapiens 242-250 12475390-11 2002 Similarly, in Sertoli cells treated with testosterone or its non-aromatizable metabolite dihydrotestosterone (100 ng/ml, 24 h), TNFalpha reduced the hormone-stimulated GSTalpha mRNA and protein levels. Dihydrotestosterone 89-108 tumor necrosis factor Homo sapiens 128-136 11918080-3 2002 Tumor necrosis factor-alpha (TNF-alpha) regulates VCAM expression on the endothelium and this effect is enhanced by dihydrotestosterone (DHT). Dihydrotestosterone 116-135 tumor necrosis factor Homo sapiens 29-38 11918080-3 2002 Tumor necrosis factor-alpha (TNF-alpha) regulates VCAM expression on the endothelium and this effect is enhanced by dihydrotestosterone (DHT). Dihydrotestosterone 137-140 tumor necrosis factor Homo sapiens 0-27 11918080-3 2002 Tumor necrosis factor-alpha (TNF-alpha) regulates VCAM expression on the endothelium and this effect is enhanced by dihydrotestosterone (DHT). Dihydrotestosterone 137-140 tumor necrosis factor Homo sapiens 29-38 10953159-15 2000 TNFalpha inhibited the ability of 10-9 M dihydrotestosterone (DHT) to induce LNCaP cell proliferation and activation of the prostate specific antigen (PSA) gene promoter. Dihydrotestosterone 41-60 tumor necrosis factor Homo sapiens 0-8 11241555-12 2001 CONCLUSIONS: Long-term exposure of TNFalpha causes hypersensitivity to DHT in LNCaP and this was associated with increased nuclear AR protein. Dihydrotestosterone 71-74 tumor necrosis factor Homo sapiens 35-43 10953159-15 2000 TNFalpha inhibited the ability of 10-9 M dihydrotestosterone (DHT) to induce LNCaP cell proliferation and activation of the prostate specific antigen (PSA) gene promoter. Dihydrotestosterone 62-65 tumor necrosis factor Homo sapiens 0-8 32141941-6 2020 RESULTS: Pretreatment with 10 M DHT or 17-beta-estradiol inhibited the high osmolarity-induced expression of TNF-alpha, IL-8, and IL-6. Dihydrotestosterone 32-35 tumor necrosis factor Homo sapiens 109-118 32755990-9 2020 DHT significantly counteracted the secretion of IL1RA, IL2, IL5, IL15, FGF, VEGF and TNFalpha. Dihydrotestosterone 0-3 tumor necrosis factor Homo sapiens 85-93 10821125-0 2000 Destabilization of tumor necrosis factor-alpha mRNA by 5-alpha dihydrotestosterone in Jurkat cells. Dihydrotestosterone 55-82 tumor necrosis factor Homo sapiens 19-46 10457265-4 1999 Treatment with 5alpha-dihydrotestosterone (DHT) dose-dependently inhibited constitutive and TNF-alpha/IL-1beta-stimulated IL-6 mRNA steady-state levels in hFOB/AR-6 cells by 70-80% at 10-7 M. In addition, testosterone also suppressed TNF-alpha/IL-1beta-stimulated IL-6 mRNA levels by 57%, while the adrenal androgen dehydroepiandrosterone had no effect. Dihydrotestosterone 15-41 tumor necrosis factor Homo sapiens 92-101 10457265-4 1999 Treatment with 5alpha-dihydrotestosterone (DHT) dose-dependently inhibited constitutive and TNF-alpha/IL-1beta-stimulated IL-6 mRNA steady-state levels in hFOB/AR-6 cells by 70-80% at 10-7 M. In addition, testosterone also suppressed TNF-alpha/IL-1beta-stimulated IL-6 mRNA levels by 57%, while the adrenal androgen dehydroepiandrosterone had no effect. Dihydrotestosterone 15-41 tumor necrosis factor Homo sapiens 234-243 10457265-4 1999 Treatment with 5alpha-dihydrotestosterone (DHT) dose-dependently inhibited constitutive and TNF-alpha/IL-1beta-stimulated IL-6 mRNA steady-state levels in hFOB/AR-6 cells by 70-80% at 10-7 M. In addition, testosterone also suppressed TNF-alpha/IL-1beta-stimulated IL-6 mRNA levels by 57%, while the adrenal androgen dehydroepiandrosterone had no effect. Dihydrotestosterone 43-46 tumor necrosis factor Homo sapiens 92-101 10457265-4 1999 Treatment with 5alpha-dihydrotestosterone (DHT) dose-dependently inhibited constitutive and TNF-alpha/IL-1beta-stimulated IL-6 mRNA steady-state levels in hFOB/AR-6 cells by 70-80% at 10-7 M. In addition, testosterone also suppressed TNF-alpha/IL-1beta-stimulated IL-6 mRNA levels by 57%, while the adrenal androgen dehydroepiandrosterone had no effect. Dihydrotestosterone 43-46 tumor necrosis factor Homo sapiens 234-243 9780231-5 1998 Among these, one distally located DH site (DH2) disappeared in both cell lines following treatment with TNFalpha. Dihydrotestosterone 34-36 tumor necrosis factor Homo sapiens 104-112 34975070-0 2021 Combined treatment with dihydrotestosterone and lipopolysaccharide modulates prostate homeostasis by upregulating TNF-alpha from M1 macrophages and promotes proliferation of prostate stromal cells. Dihydrotestosterone 24-43 tumor necrosis factor Homo sapiens 114-123 34975070-5 2021 We found that DHT increased secretion of the pro-inflammatory factor tumor necrosis factor (TNF)-alpha from M1 macrophages differentiated from THP-1 cells. Dihydrotestosterone 14-17 tumor necrosis factor Homo sapiens 69-102 34975070-10 2021 This study suggests that DHT modulates the inflammatory environment of BPH by increasing TNF-alpha expression from lipopolysaccharide-treated M1 macrophages and promotes the proliferation of prostate stromal cells. Dihydrotestosterone 25-28 tumor necrosis factor Homo sapiens 89-98 29194865-11 2018 We confirmed that DHT enhanced macrophages TNF-alpha secretion through AR signalling. Dihydrotestosterone 18-21 tumor necrosis factor Homo sapiens 43-52 31738650-5 2021 When these LPS + LBP-stimulated cells were exposed to DHT for 2 days, it was found that DHT suppressed the secretion of IL-6, IL-10, IL-1beta, VEGF-A cytokines in corneal epithelial cells; TNF-alpha, IL-6, IL-1beta, VEGF-A cytokines in conjunctival epithelial cells; and IL-6, IL-1beta, VEGF-A cytokines in meibomian gland epithelial cells.Conclusion: LPS + LBP is shown to induce the secretion of certain proinflammatory cytokines from ocular surface and adnexal epithelial cells. Dihydrotestosterone 88-91 tumor necrosis factor Homo sapiens 189-198 30794859-7 2019 In line with this, DHT increased the activities of the c-Jun promoter and the tumor necrosis factor alpha promoter, which both contain AP-1 binding sites. Dihydrotestosterone 19-22 tumor necrosis factor Homo sapiens 78-105 31876682-5 2020 Also, DHT inhibited HG-induced expression of TNF-alpha and IL-1beta. Dihydrotestosterone 6-9 tumor necrosis factor Homo sapiens 45-54 24947177-6 2014 In both HUVEC genders, the inflammatory effect of TNF-alpha was amplified by co-administration of T or DHT and several AAS frequently used in doping, while E2 had no effect. Dihydrotestosterone 103-106 tumor necrosis factor Homo sapiens 50-59 22912365-3 2012 The antiapoptotic effect of DHT on human epithelial HSG cells exposed to tumor necrosis factor-alpha and cycloheximide was studied. Dihydrotestosterone 28-31 tumor necrosis factor Homo sapiens 73-100 22504554-5 2012 The effect of testosterone (10-50 nM), dihydrotestosterone (5-50 nM), and estradiol (0.1-0.4 nM) on the adhesion of tumor necrosis factor-alpha (TNF-alpha)-stimulated HCAECs was determined at different time points (12-96 h) by assessing their binding with human monocytic THP-1 cells. Dihydrotestosterone 39-58 tumor necrosis factor Homo sapiens 116-143