PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26044185-7 2016 Expression of 5alpha-red and androgen receptor genes showed a good correlation with DHT levels in both regions. Dihydrotestosterone 84-87 androgen receptor Rattus norvegicus 29-46 25511993-10 2015 Taken together, these results imply that enhanced spinogenesis by DHT and T is mediated by synaptic/extranuclear AR which rapidly drives the kinase networks. Dihydrotestosterone 66-69 androgen receptor Rattus norvegicus 113-115 27389922-11 2016 Testosterone and its metabolite 5alpha-dihydrotestosterone protect neurons via the genomic pathway of the androgen receptor. Dihydrotestosterone 32-58 androgen receptor Rattus norvegicus 106-123 22976277-3 2012 Neonatal rats received diethylstilbestrol (DES), with or without the estrogen receptor (ESR) antagonist ICI 182,780 (ICI) or the androgen receptor (AR) agonist dihydrotestosterone (DHT), from Postnatal Days 1 to 6. Dihydrotestosterone 160-179 androgen receptor Rattus norvegicus 148-150 24055403-8 2013 Furthermore, luciferase reporter assay revealed that AR activated the CB1 gene in response to testosterone or dihydrotestosterone treatment. Dihydrotestosterone 110-129 androgen receptor Rattus norvegicus 53-55 23689136-4 2013 We found that although both T and DHT stimulate androgen receptor (AR) binding to the LRH-1 promoter, DHT prevents T-mediated stimulation of LRH-1 expression. Dihydrotestosterone 34-37 androgen receptor Rattus norvegicus 48-65 23689136-4 2013 We found that although both T and DHT stimulate androgen receptor (AR) binding to the LRH-1 promoter, DHT prevents T-mediated stimulation of LRH-1 expression. Dihydrotestosterone 34-37 androgen receptor Rattus norvegicus 67-69 23449329-6 2013 Yeast two-hybrid interaction assays revealed that DHT promoted recruitment of numerous cofactors to AR such as TIF2, SRC1, beta-catenin, NCoA3, gelsolin and PROX1 in a dose-dependent manner. Dihydrotestosterone 50-53 androgen receptor Rattus norvegicus 100-102 21048966-4 2010 Reduction of androgen levels in Sprague-Dawley rats by castration inhibited the expression of a large set of miRs in prostate and muscle, which was reversed by treatment of castrated rats with 3 mg/day dihydrotestosterone (DHT) or selective androgen receptor modulators. Dihydrotestosterone 202-221 androgen receptor Rattus norvegicus 241-258 21819988-5 2011 One week of DHT exposure decreased androgen receptor (AR) expression in the hypothalamus and leptin synthesis and function in adipocytes; it also inhibited signal transducer and activator of transcription 3 (STAT3) and attenuated leptin activity by increasing levels of soluble leptin receptor, a leptin-binding protein, in the hypothalamus. Dihydrotestosterone 12-15 androgen receptor Rattus norvegicus 35-52 21819988-5 2011 One week of DHT exposure decreased androgen receptor (AR) expression in the hypothalamus and leptin synthesis and function in adipocytes; it also inhibited signal transducer and activator of transcription 3 (STAT3) and attenuated leptin activity by increasing levels of soluble leptin receptor, a leptin-binding protein, in the hypothalamus. Dihydrotestosterone 12-15 androgen receptor Rattus norvegicus 54-56 21271819-2 2011 To test the hypothesis that testosterone (T) and 5a-dihydrotestosterone (DHT) modulate CNS catecholamines and BP through androgen receptor (AR)-dependent and independent mechanisms, we used the testicular feminized male (Tfm) rat. Dihydrotestosterone 73-76 androgen receptor Rattus norvegicus 121-138 21048966-4 2010 Reduction of androgen levels in Sprague-Dawley rats by castration inhibited the expression of a large set of miRs in prostate and muscle, which was reversed by treatment of castrated rats with 3 mg/day dihydrotestosterone (DHT) or selective androgen receptor modulators. Dihydrotestosterone 223-226 androgen receptor Rattus norvegicus 241-258 20444881-4 2010 The androgen receptor (AR) relative binding affinities ranged from 0.1 to 26.5% (relative to dihydrotestosterone) and demonstrated a range of agonist activity at 100 nM. Dihydrotestosterone 93-112 androgen receptor Rattus norvegicus 4-21 20444881-4 2010 The androgen receptor (AR) relative binding affinities ranged from 0.1 to 26.5% (relative to dihydrotestosterone) and demonstrated a range of agonist activity at 100 nM. Dihydrotestosterone 93-112 androgen receptor Rattus norvegicus 23-25 19729001-2 2009 Recent work in our laboratory showed that the androgens testosterone and dihydrotestosterone (DHT) activate androgen receptor (AR)-dependent mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling. Dihydrotestosterone 73-92 androgen receptor Rattus norvegicus 108-125 19941958-6 2010 Bolandiol was stimulatory in all these assays, but only 4-9% as potent as T, DHT, and 19-NT via AR, 1% as potent as progesterone via PR, and 3% and 1% as potent as E(2) acting through ERalpha or ERbeta, respectively. Dihydrotestosterone 77-80 androgen receptor Rattus norvegicus 96-98 19729001-2 2009 Recent work in our laboratory showed that the androgens testosterone and dihydrotestosterone (DHT) activate androgen receptor (AR)-dependent mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling. Dihydrotestosterone 73-92 androgen receptor Rattus norvegicus 127-129 19729001-2 2009 Recent work in our laboratory showed that the androgens testosterone and dihydrotestosterone (DHT) activate androgen receptor (AR)-dependent mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling. Dihydrotestosterone 94-97 androgen receptor Rattus norvegicus 108-125 19729001-2 2009 Recent work in our laboratory showed that the androgens testosterone and dihydrotestosterone (DHT) activate androgen receptor (AR)-dependent mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling. Dihydrotestosterone 94-97 androgen receptor Rattus norvegicus 127-129 19729001-5 2009 Further, we observed that DHT-induced CREB phosphorylation is AR-dependent, as it occurs in PC12 cells stably transfected with AR but in neither wild-type nor empty vector-transfected cells. Dihydrotestosterone 26-29 androgen receptor Rattus norvegicus 62-64 19729001-5 2009 Further, we observed that DHT-induced CREB phosphorylation is AR-dependent, as it occurs in PC12 cells stably transfected with AR but in neither wild-type nor empty vector-transfected cells. Dihydrotestosterone 26-29 androgen receptor Rattus norvegicus 127-129 18292193-4 2008 5alpha-Androstane-3beta, 17beta-diol (3betaAdiol), a metabolite of testosterone produced via the intermediate potent androgen 5alpha-dihydrotestosterone (DHT), has been reported to selectively bind ERbeta rather than EpsilonRalpha, but not androgen receptor. Dihydrotestosterone 126-152 androgen receptor Rattus norvegicus 240-257 19680559-12 2009 Thus, rats with DHT-induced PCOS have disrupted estrous cyclicity and an increased number of hypothalamic cells expressing GnRH, most likely mediated by AR activation. Dihydrotestosterone 16-19 androgen receptor Rattus norvegicus 153-155 18346198-7 2008 DHT also significantly decreased levels of Abeta in AR-expressing cells transfected with amyloid precursor protein, but did not affect levels of either full-length or non-amyloidogenic, soluble amyloid precursor protein. Dihydrotestosterone 0-3 androgen receptor Rattus norvegicus 52-54 18346198-9 2008 The DHT-mediated increase in NEP expression and decrease in Abeta levels were (i) not observed in rat pheochromocytoma cell 12 lacking AR and (ii) blocked in AR-expressing cells by the antagonists, cyproterone acetate and flutamide. Dihydrotestosterone 4-7 androgen receptor Rattus norvegicus 135-137 18346198-9 2008 The DHT-mediated increase in NEP expression and decrease in Abeta levels were (i) not observed in rat pheochromocytoma cell 12 lacking AR and (ii) blocked in AR-expressing cells by the antagonists, cyproterone acetate and flutamide. Dihydrotestosterone 4-7 androgen receptor Rattus norvegicus 158-160 18292193-4 2008 5alpha-Androstane-3beta, 17beta-diol (3betaAdiol), a metabolite of testosterone produced via the intermediate potent androgen 5alpha-dihydrotestosterone (DHT), has been reported to selectively bind ERbeta rather than EpsilonRalpha, but not androgen receptor. Dihydrotestosterone 154-157 androgen receptor Rattus norvegicus 240-257 18234307-3 2008 Androgen receptor expression is up-regulated by systemic chronic administration of anabolic androgens, 5alpha-dihydrotestosterone or estradiol benzoate. Dihydrotestosterone 103-129 androgen receptor Rattus norvegicus 0-17 15498879-9 2005 However, DHT appears not to activate ERalpha directly because DHT induction of IGF-I is blocked by the AR antagonist bicalutamide, and multiple genes regulated directly by ERalpha were not induced by DHT. Dihydrotestosterone 62-65 androgen receptor Rattus norvegicus 103-105 17660230-6 2007 Likewise, the ability of testosterone or dihydrotestosterone to negate these abnormalities suggests a role for an androgen receptor (AR)-mediated pathway. Dihydrotestosterone 41-60 androgen receptor Rattus norvegicus 114-131 17660230-6 2007 Likewise, the ability of testosterone or dihydrotestosterone to negate these abnormalities suggests a role for an androgen receptor (AR)-mediated pathway. Dihydrotestosterone 41-60 androgen receptor Rattus norvegicus 133-135 15498879-9 2005 However, DHT appears not to activate ERalpha directly because DHT induction of IGF-I is blocked by the AR antagonist bicalutamide, and multiple genes regulated directly by ERalpha were not induced by DHT. Dihydrotestosterone 62-65 androgen receptor Rattus norvegicus 103-105 15354540-2 2004 Using radioligand methods, gel filtration on Toyopearl HW-55F column and analyses of specific testicular cytosol 5-alpha-dihydrotestosterone binding in Scatchard and Hill plots it was shown that functional androgen receptor complexes (ARC"s) are dimers exhibiting positive cooperativity during hormone ligand binding. Dihydrotestosterone 113-140 androgen receptor Rattus norvegicus 206-223 15232065-5 2004 Replacement with DHT and testosterone alone or in combination with estradiol caused the recovery of AR expression to control levels. Dihydrotestosterone 17-20 androgen receptor Rattus norvegicus 100-102 14643878-8 2003 The relative binding affinity (RBA) of either 7alpha-cyano-(17alpha,20E/Z)-IVNT isomer for the AR is low (RBA=4 and 3, respectively, versus 100 for 5alpha-dihydrotestosterone (DHT)), suggesting the absence of a possible role of the AR in the localization process. Dihydrotestosterone 176-179 androgen receptor Rattus norvegicus 95-97 14761201-6 2004 Although some compounds were unable to stimulate AR-mediated transcription, several demonstrated activity similar to that of dihydrotestosterone (DHT, an endogenous steroidal ligand for the AR). Dihydrotestosterone 125-144 androgen receptor Rattus norvegicus 190-192 14761201-6 2004 Although some compounds were unable to stimulate AR-mediated transcription, several demonstrated activity similar to that of dihydrotestosterone (DHT, an endogenous steroidal ligand for the AR). Dihydrotestosterone 146-149 androgen receptor Rattus norvegicus 190-192 11801526-2 2002 Surprisingly, we found that AR(+) CA25 cells grew slower in the presence of dihydrotestosterone (DHT), whereas the growth of AR(-) CA25 cells was not affected by the hormone. Dihydrotestosterone 76-95 androgen receptor Rattus norvegicus 28-30 12773767-1 2003 Finasteride is a specific inhibitor of type II 5alpha-reductase, the enzyme that converts testosterone (T) to the more potent androgen receptor agonist dihydrotestosterone (DHT). Dihydrotestosterone 152-171 androgen receptor Rattus norvegicus 126-143 12773767-1 2003 Finasteride is a specific inhibitor of type II 5alpha-reductase, the enzyme that converts testosterone (T) to the more potent androgen receptor agonist dihydrotestosterone (DHT). Dihydrotestosterone 173-176 androgen receptor Rattus norvegicus 126-143 12890564-5 2003 Substitution of testosterone by the non-aromatizable androgen dihydrotestosterone gave rise to comparable changes in the mRNA and protein levels of the lipogenic genes under investigation, confirming the involvement of the androgen receptor in the observed effects. Dihydrotestosterone 62-81 androgen receptor Rattus norvegicus 223-240 11801526-2 2002 Surprisingly, we found that AR(+) CA25 cells grew slower in the presence of dihydrotestosterone (DHT), whereas the growth of AR(-) CA25 cells was not affected by the hormone. Dihydrotestosterone 97-100 androgen receptor Rattus norvegicus 28-30 11092397-10 2000 Proliferation associated with testosterone appears to follow its aromatization to estrogen and is mediated through the ER, whereas proliferation associated with 5alpha-dihydrotestosterone is mediated by the androgen receptor. Dihydrotestosterone 161-187 androgen receptor Rattus norvegicus 207-224 10935541-7 2000 Similarly, antiandrogenic ligands, cyproterone acetate and casodex, were also capable of translocating the cytoplasmic AR into the nucleus albeit at a slower rate than the androgen 5alpha-dihydrotestosterone (DHT). Dihydrotestosterone 209-212 androgen receptor Rattus norvegicus 119-121 10935541-10 2000 Subsequent exposure of the casodex-treated cell to DHT rapidly (15-30 min) altered the homogeneous to punctate distribution of the already translocated nuclear AR. Dihydrotestosterone 51-54 androgen receptor Rattus norvegicus 160-162 10935541-11 2000 When transported into the nucleus either by casodex or by DHT, GFP-AR was resistant to 2 M NaCl extraction, indicating that the homogeneously distributed AR is also associated with the nuclear matrix. Dihydrotestosterone 58-61 androgen receptor Rattus norvegicus 67-69 10913783-0 2000 Dihydrotestosterone and estrogen regulation of rat brain androgen-receptor immunoreactivity. Dihydrotestosterone 0-19 androgen receptor Rattus norvegicus 57-74 10913783-1 2000 Androgen-receptor upregulation that occurs with androgenic-anabolic steroid (AAS) administration may be mediated by AAS metabolites, dihydrotestosterone (DHT), and estrogen. Dihydrotestosterone 133-152 androgen receptor Rattus norvegicus 0-17 10913783-1 2000 Androgen-receptor upregulation that occurs with androgenic-anabolic steroid (AAS) administration may be mediated by AAS metabolites, dihydrotestosterone (DHT), and estrogen. Dihydrotestosterone 154-157 androgen receptor Rattus norvegicus 0-17 10188194-2 1999 For example, in utero treatment with the androgen receptor (AR) antagonist, flutamide, produces ventral prostate agenesis and testicular nondescent, while in contrast, finasteride, an inhibitor of 5 alpha-dihydrotestosterone (DHT) synthesis, rarely, if ever, induces such malformations. Dihydrotestosterone 226-229 androgen receptor Rattus norvegicus 41-58 10725371-5 2000 In contrast, androgen receptor (AR) mRNA level in the hypothalamus was slightly reduced by castration and increased by treatment with DHT. Dihydrotestosterone 134-137 androgen receptor Rattus norvegicus 13-30 10725371-5 2000 In contrast, androgen receptor (AR) mRNA level in the hypothalamus was slightly reduced by castration and increased by treatment with DHT. Dihydrotestosterone 134-137 androgen receptor Rattus norvegicus 32-34 10354410-2 1999 The relative binding affinity to the androgen receptor determined in competition assays showed that in the androstane series the fluoro steroids have the highest affinity and that F-17alpha-CH3-DHT (4) has a higher affinity than 5alpha-DHT. Dihydrotestosterone 229-239 androgen receptor Rattus norvegicus 37-54 10354410-4 1999 The relative biological activity in cells transfected with the androgen receptor and an androgen responsive reporter gene is 4 >> 5alpha-DHT > 2 > 6 > 3 >/= 1 >/= 8 >/= 5 > 7. Dihydrotestosterone 136-146 androgen receptor Rattus norvegicus 63-80 10188194-2 1999 For example, in utero treatment with the androgen receptor (AR) antagonist, flutamide, produces ventral prostate agenesis and testicular nondescent, while in contrast, finasteride, an inhibitor of 5 alpha-dihydrotestosterone (DHT) synthesis, rarely, if ever, induces such malformations. Dihydrotestosterone 226-229 androgen receptor Rattus norvegicus 60-62 8828500-8 1996 Treatment with 5 alpha-dihydrotestosterone (1 microM) resulted in a significant reduction in the abundance of AR mRNA to 67% of the control value (P < 0.05). Dihydrotestosterone 15-42 androgen receptor Rattus norvegicus 110-112 9593936-5 1998 The compounds that produced the greatest stimulation of aromatase activity were those that bound most avidly to the androgen receptor in vitro (i.e., testosterone, dihydrotestosterone and nandrolone). Dihydrotestosterone 164-183 androgen receptor Rattus norvegicus 116-133 9048585-9 1997 Because DHT is a high affinity ligand for the androgen receptor and androstenedione shows very little, if any, affinity for the receptor, these studies suggest that 5 alpha-reduction of testosterone may be a mechanism to amplify androgen action in urogenital tissues such as the prostate by preventing catabolism of testosterone to the inactive androgen, androstenedione, at the site of hormone action. Dihydrotestosterone 8-11 androgen receptor Rattus norvegicus 46-63 7821714-6 1994 Administration of 5 alpha-dihydrotestosterone to pregnant rats at a dose of 50 mg/kg body weight per day from day 12 to day 22 caused an increase in immunoreactive androgen receptor in the female urogenital sinus and tubercle to levels approaching those in male tissues. Dihydrotestosterone 18-45 androgen receptor Rattus norvegicus 164-181 8770883-11 1996 Treatment of hypophysectomized rats with 5alpha-dihydrotestosterone for 7 days caused a dramatic increase in the amount of detectable AR in both the ventral prostate and the adrenal gland, but had a trophic effect only in the ventral prostate. Dihydrotestosterone 41-67 androgen receptor Rattus norvegicus 134-136 8639471-6 1996 As a result of these findings, DHT production from testosterone and expression of androgen receptor mRNA, we concluded that RSS18 proliferation may be stimulated by DHT through 5alpha-reductase from testosterone. Dihydrotestosterone 165-168 androgen receptor Rattus norvegicus 82-99 2257240-9 1990 Slight binding affinity for androgen receptor was observed with FCE 24304 and 4-OHA (0.21 and 0.25% of DHT). Dihydrotestosterone 103-106 androgen receptor Rattus norvegicus 28-45 8056636-3 1994 If, indeed, T regulation of spermatogenesis is mediated through the androgen receptor, 5 alpha-dihydrotestosterone (DHT) would be expected to more effectively maintain spermatogenesis than T because of its greater affinity for, and slower rate of dissociation from, the androgen receptor. Dihydrotestosterone 116-119 androgen receptor Rattus norvegicus 68-85 8056636-3 1994 If, indeed, T regulation of spermatogenesis is mediated through the androgen receptor, 5 alpha-dihydrotestosterone (DHT) would be expected to more effectively maintain spermatogenesis than T because of its greater affinity for, and slower rate of dissociation from, the androgen receptor. Dihydrotestosterone 116-119 androgen receptor Rattus norvegicus 270-287 8361343-6 1993 Castration (4 days) resulted in significantly increased AR mRNA in the AP and hypothalamic-preoptic area, but not the amygdala, which subsequent administration of dihydrotestosterone (DHT; 1 day; 2 mg/animal) significantly decreased. Dihydrotestosterone 184-187 androgen receptor Rattus norvegicus 56-58 2282981-1 1990 The androgen receptor (AR) is activated upon binding of testosterone or dihydrotestosterone and exerts regulatory effects on gene expression in androgen target cells. Dihydrotestosterone 72-91 androgen receptor Rattus norvegicus 4-21 2282981-1 1990 The androgen receptor (AR) is activated upon binding of testosterone or dihydrotestosterone and exerts regulatory effects on gene expression in androgen target cells. Dihydrotestosterone 72-91 androgen receptor Rattus norvegicus 23-25 2117526-10 1990 Furthermore, the failure of estradiol to substitute for testosterone and the ability of DHT to substantially support GHRH mRNA suggest that testosterone exerts its effects on GHRH gene expression predominantly through direct activation of the androgen receptor. Dihydrotestosterone 88-91 androgen receptor Rattus norvegicus 243-260 34180022-2 2021 In contrast, exposure to 5alpha-dihydrotestosterone (DHT) and insulin (INS) or DHT alone significantly increased AR protein levels in the uterus in association with the aberrant expression of endometrial receptivity and decidualization genes, as well as disrupted implantation. Dihydrotestosterone 25-51 androgen receptor Rattus norvegicus 113-115 2189281-6 1990 Norgestimate"s affinity for the androgen receptor is very poor (0.003 x dihydrotestosterone [DHT]), even poorer than that of progesterone (0.005 x DHT). Dihydrotestosterone 72-91 androgen receptor Rattus norvegicus 32-49 2189281-6 1990 Norgestimate"s affinity for the androgen receptor is very poor (0.003 x dihydrotestosterone [DHT]), even poorer than that of progesterone (0.005 x DHT). Dihydrotestosterone 93-96 androgen receptor Rattus norvegicus 32-49 2189281-6 1990 Norgestimate"s affinity for the androgen receptor is very poor (0.003 x dihydrotestosterone [DHT]), even poorer than that of progesterone (0.005 x DHT). Dihydrotestosterone 147-150 androgen receptor Rattus norvegicus 32-49 34180022-2 2021 In contrast, exposure to 5alpha-dihydrotestosterone (DHT) and insulin (INS) or DHT alone significantly increased AR protein levels in the uterus in association with the aberrant expression of endometrial receptivity and decidualization genes, as well as disrupted implantation. Dihydrotestosterone 53-56 androgen receptor Rattus norvegicus 113-115 34180022-2 2021 In contrast, exposure to 5alpha-dihydrotestosterone (DHT) and insulin (INS) or DHT alone significantly increased AR protein levels in the uterus in association with the aberrant expression of endometrial receptivity and decidualization genes, as well as disrupted implantation. Dihydrotestosterone 79-82 androgen receptor Rattus norvegicus 113-115 34180022-4 2021 We found that AR blockage using flutamide largely attenuated the DHT and INS-induced maternal endocrine, metabolic, and fertility impairments in pregnant rats in association with suppressed induction of uterine AR protein abundance and androgen-regulated response protein and normalized expression of several endometrial receptivity and decidualization genes. Dihydrotestosterone 65-68 androgen receptor Rattus norvegicus 14-16 34180022-4 2021 We found that AR blockage using flutamide largely attenuated the DHT and INS-induced maternal endocrine, metabolic, and fertility impairments in pregnant rats in association with suppressed induction of uterine AR protein abundance and androgen-regulated response protein and normalized expression of several endometrial receptivity and decidualization genes. Dihydrotestosterone 65-68 androgen receptor Rattus norvegicus 211-213 34180022-11 2021 Pregnant rats exposed to 5alpha-dihydrotestosterone (DHT) and insulin (INS) or to DHT alone show elevated uterine AR protein abundance and implantation failure related to the aberrant expression of genes involved in endometrial receptivity and decidualization in early to mid-gestation. Dihydrotestosterone 25-51 androgen receptor Rattus norvegicus 114-116 34180022-11 2021 Pregnant rats exposed to 5alpha-dihydrotestosterone (DHT) and insulin (INS) or to DHT alone show elevated uterine AR protein abundance and implantation failure related to the aberrant expression of genes involved in endometrial receptivity and decidualization in early to mid-gestation. Dihydrotestosterone 53-56 androgen receptor Rattus norvegicus 114-116 34180022-11 2021 Pregnant rats exposed to 5alpha-dihydrotestosterone (DHT) and insulin (INS) or to DHT alone show elevated uterine AR protein abundance and implantation failure related to the aberrant expression of genes involved in endometrial receptivity and decidualization in early to mid-gestation. Dihydrotestosterone 82-85 androgen receptor Rattus norvegicus 114-116 34129879-6 2021 Docking data showed that kaempferol could bind to ASN705 and THR877 residues of androgen receptor which were also the binding sites of dihydrotestosterone. Dihydrotestosterone 135-154 androgen receptor Rattus norvegicus 80-97 3485449-6 1986 Scatchard analysis of salt-extracted nuclear androgen receptor (ARn) showed a single, high-affinity binding site with similar Kd values in PIT and HPA of intact and castrated, DHT-treated male rats (PIT Kd = 7.3 X 10(-10) M, 9.3 X 10(-10) M; HPA Kd = 1.5 X 10(-9) M, 1.3 X 10(-9) M, respectively). Dihydrotestosterone 176-179 androgen receptor Rattus norvegicus 45-62 35038776-3 2022 Furthermore, exposure to DHT alone increased uterine ferroptosis, and NRF2 abundance was negatively correlated with AR status. Dihydrotestosterone 25-28 androgen receptor Rattus norvegicus 116-118 35038776-4 2022 Co-immunoprecipitation and Western blot assays revealed that the AR physically interacted with endogenous NRF2, and this interaction was increased by DHT exposure in vivo. Dihydrotestosterone 150-153 androgen receptor Rattus norvegicus 65-67 2514815-2 1989 That DHT acts through interaction with the androgen receptor is supported by the finding that simultaneous treatment with the antiandrogen Flutamide completely prevents DHT action. Dihydrotestosterone 5-8 androgen receptor Rattus norvegicus 43-60 2514815-2 1989 That DHT acts through interaction with the androgen receptor is supported by the finding that simultaneous treatment with the antiandrogen Flutamide completely prevents DHT action. Dihydrotestosterone 169-172 androgen receptor Rattus norvegicus 43-60 2644508-3 1989 Androgen receptor sites were measured by sucrose density gradient and charcoal assay using tritiated dihydrotestosterone (DHT). Dihydrotestosterone 122-125 androgen receptor Rattus norvegicus 0-17 2469075-2 1989 Under our androgen binding assay conditions, the effect of acid phosphatase inhibitors (sodium fluoride, tartaric acid, sodium orthovanadate) on the endogenous phosphatases could be correlated with an increase in dihydrotestosterone (DHT) binding to fractions of partially purified cytosolic androgen receptor. Dihydrotestosterone 213-232 androgen receptor Rattus norvegicus 292-309 2469075-4 1989 Immunoprecipitation of androgen receptor fractions with polyclonal anti-phosphotyrosine antibody resulted in the recovery of [3H]-DHT binding activity from nuclear receptor fractions and partially purified cytosolic receptor fractions prepared from 20- to 24-hr castrated rats. Dihydrotestosterone 130-133 androgen receptor Rattus norvegicus 23-40 3216867-7 1988 Antisera reacted with high titer against the synthetic peptide by enzyme-linked immunosorbent assay and against the native [3H]dihydrotestosterone-labeled androgen receptor as evidenced by an increase in receptor sedimentation rate determined by sucrose gradient centrifugation. Dihydrotestosterone 127-146 androgen receptor Rattus norvegicus 155-172 3783591-1 1986 A series of steroids, primarily 4-azasteroids, were prepared and tested in vitro as inhibitors of human and rat prostatic 5 alpha-reductase and of binding of dihydrotestosterone to the rat androgen receptor. Dihydrotestosterone 158-177 androgen receptor Rattus norvegicus 189-206 3736037-4 1986 The 17 alpha-allyl-DHT had about 50% of DHT"s affinity for rat uterine androgen receptor, while the affinity of the major epoxide isomer was 9% and that of the minor isomer was 4%. Dihydrotestosterone 19-22 androgen receptor Rattus norvegicus 71-88 3736037-7 1986 The use of the new DHT beads in purifications of the androgen receptor and other binding proteins is now being explored by other laboratories. Dihydrotestosterone 19-22 androgen receptor Rattus norvegicus 53-70 3488063-1 1986 Binding of androgens including 5 alpha-dihydrotestosterone, testosterone and androstenedione stabilized the androgen receptor from rat submandibular gland with respect to its [3H]methyltrienolone binding activity. Dihydrotestosterone 31-58 androgen receptor Rattus norvegicus 108-125 4068702-3 1985 The validity of the present exchange assay is based on the following: a similar quantity of androgen receptor was detected when binding was measured directly after in vivo treatment with radioactive androgen or indirectly by [3H]DHT exchange after treatment with non-radioactive androgen. Dihydrotestosterone 229-232 androgen receptor Rattus norvegicus 92-109 6607463-4 1984 Binding of R1881 was low but specific for the androgen receptor as shown by competition studies in which nonlabeled R1881, 5 alpha-dihydrotestosterone, and testosterone competed successfully with 3H-R1881 for binding sites, but 17 beta-estradiol and low levels of progesterone did not. Dihydrotestosterone 123-150 androgen receptor Rattus norvegicus 46-63 6609069-1 1984 This study compares the physicochemical characteristics of the androgen-receptor hormone complexes formed in vitro by incubation of prostatic cytosol with tritiated 5 alpha-dihydrotestosterone (DHT) and methyltrienolone (R1881; 17 beta-hydroxy-17 alpha-methyl-4,9, 11-estra-trien-3-one) with those of hormone-receptor complexes formed in vivo upon hormone injection. Dihydrotestosterone 165-192 androgen receptor Rattus norvegicus 63-80 6609069-1 1984 This study compares the physicochemical characteristics of the androgen-receptor hormone complexes formed in vitro by incubation of prostatic cytosol with tritiated 5 alpha-dihydrotestosterone (DHT) and methyltrienolone (R1881; 17 beta-hydroxy-17 alpha-methyl-4,9, 11-estra-trien-3-one) with those of hormone-receptor complexes formed in vivo upon hormone injection. Dihydrotestosterone 194-197 androgen receptor Rattus norvegicus 63-80 6609069-2 1984 [3H]DHT and [3H]R1881 had similar affinities for the androgen receptor in vitro (Kd = 0.3 nM). Dihydrotestosterone 4-7 androgen receptor Rattus norvegicus 53-70 6645492-2 1983 One-hundred micrograms of DHT which has been shown by previous workers [4] to saturate the androgen receptor but not bind or translocate estrogen receptor was injected daily into immature rats with or without 5 micrograms of 17 beta estradiol (E2) for three consecutive days. Dihydrotestosterone 26-29 androgen receptor Rattus norvegicus 91-108 6887871-6 1983 These 5 alpha-reductase inhibitors also have an affinity to the androgen receptor which is orders of magnitude lower than that of 5 alpha-dihydrotestosterone (DHT), spironolactone and cyproterone acetate. Dihydrotestosterone 130-157 androgen receptor Rattus norvegicus 64-81 7159407-1 1982 The dynamic status of the androgen receptor in prostate cells was studied by incubation of rat ventral prostate with radioactive 17beta-hydroxy-5alpha-androstan-3-one (5alpha-dihydrotestosterone) in the presence and absence of respiratory poisons and inhibitors of protein and RNA synthesis and also by isotope chasing of the radioactive androgen-receptor complexes. Dihydrotestosterone 168-194 androgen receptor Rattus norvegicus 26-43 6193048-1 1983 In intact adult rats almost all androgen receptor (AR) sites of the rat ventral prostate (RVP) are occupied by endogenous dihydrotestosterone, and about 80% of these sites are nuclear. Dihydrotestosterone 122-141 androgen receptor Rattus norvegicus 51-53 7160340-6 1982 It is concluded that testosterone and 19-nortestosterone (which are equally good substrates for 5 alpha-reductase) are converted in the seminal vesicles to metabolites, of which DHT exhibits an affinity to the androgen receptor nearly one order of magnitude higher than that of DHN. Dihydrotestosterone 178-181 androgen receptor Rattus norvegicus 210-227 7132347-1 1982 Competition of 22 steroids with [3H]-dihydrotestosterone for the binding to the androgen receptor of the rat seminal vesicle has been studied. Dihydrotestosterone 32-56 androgen receptor Rattus norvegicus 80-97 7049789-3 1982 In our view the action of androgens on the prostate are exerted exclusively through the binding of 5 alpha-dihydrotestosterone to the androgen receptor and its subsequent translocation to the nucleus. Dihydrotestosterone 99-126 androgen receptor Rattus norvegicus 134-151 7075544-1 1982 Methods have been developed for the measurement of nonradioactive or radioactive dihydrotestosterone (DHT) bound to androgen receptor in rat ventral prostate nuclei (DHTRn). Dihydrotestosterone 81-100 androgen receptor Rattus norvegicus 116-133 7075544-1 1982 Methods have been developed for the measurement of nonradioactive or radioactive dihydrotestosterone (DHT) bound to androgen receptor in rat ventral prostate nuclei (DHTRn). Dihydrotestosterone 102-105 androgen receptor Rattus norvegicus 116-133 7053985-7 1982 However, Teslac inhibited DHT binding to the androgen receptor (Ki = 2.5 +/- 0.8 X 10(-7) M) in cytosol of the rat prostate. Dihydrotestosterone 26-29 androgen receptor Rattus norvegicus 45-62 7210056-1 1980 The androgen receptor from rat prostate binds 5 alpha-dihydrotestosterone and related androgenic steroids at a steroid binding site and in addition shows selective binding to structures related to nucleic acids (chromatin binding site). Dihydrotestosterone 46-73 androgen receptor Rattus norvegicus 4-21 7263637-4 1981 This affinity to the androgen receptor is 1,000-, 500-, 120-, and 40-fold lower than that of 5 alpha-dihydrotestosterone, testosterone, spironolactone, and cyproterone acetate, respectively, and 7-fold higher than that of cimetidine. Dihydrotestosterone 93-120 androgen receptor Rattus norvegicus 21-38 6249575-0 1980 Marihuana inhibits dihydrotestosterone binding to the androgen receptor. Dihydrotestosterone 19-38 androgen receptor Rattus norvegicus 54-71 6249575-2 1980 Smoked marihuana condensate, delta 9-THC, and CBN inhibit specific binding of dihydrotestosterone (DHT) to the androgen receptor with a dissociatin constant of the inhibitors (Li) of 2.1-5.8 X 10(-7)M. in addition, other metabolites of delta 9-THC were also androgen antagonists. Dihydrotestosterone 78-97 androgen receptor Rattus norvegicus 111-128 6249575-2 1980 Smoked marihuana condensate, delta 9-THC, and CBN inhibit specific binding of dihydrotestosterone (DHT) to the androgen receptor with a dissociatin constant of the inhibitors (Li) of 2.1-5.8 X 10(-7)M. in addition, other metabolites of delta 9-THC were also androgen antagonists. Dihydrotestosterone 99-102 androgen receptor Rattus norvegicus 111-128 758974-4 1979 Its Kd for both dihydrotestosterone and testosterone is about 1 X 10(-9) M and for estradiol about 2 X 10(-8) M. Its properties are generally consistent with those of androgen receptor reported for other tissues. Dihydrotestosterone 16-35 androgen receptor Rattus norvegicus 167-184 991822-11 1976 The serum levels of testosterone (7.7+/-0.15 (SE) ng/ml) and 5alpha-dihydrotestosterone (0.37+/-0.06 ng/ml) were significantly higher in intact Tfm rats than in normal littermates (2.6+/-0.03 and less than 0.1 ng/ml, respectively). Dihydrotestosterone 61-87 androgen receptor Rattus norvegicus 144-147 611640-1 1977 Postmitochondrial supernatant (PMS) (1) has been prepared from the homogenate of rat seminal vesicles and the characteristics of the binding reaction of 5alpha-dihydrotestosterone (DHT) to the cytoplasmic androgen receptor have been studied using a charcoal adsorption procedure. Dihydrotestosterone 153-179 androgen receptor Rattus norvegicus 205-222 611640-1 1977 Postmitochondrial supernatant (PMS) (1) has been prepared from the homogenate of rat seminal vesicles and the characteristics of the binding reaction of 5alpha-dihydrotestosterone (DHT) to the cytoplasmic androgen receptor have been studied using a charcoal adsorption procedure. Dihydrotestosterone 181-184 androgen receptor Rattus norvegicus 205-222 841615-3 1977 Injection of 100 mug DHT induced a maximal occupation of androgen receptor sites (RA) but was totally ineffective in translocating the estrogen receptor sites and in increasing general protein synthesis. Dihydrotestosterone 21-24 androgen receptor Rattus norvegicus 57-74 31591335-4 2019 DHT binds to an androgen receptor (AR) and steroid receptor coactivator 1 (SRC-1); then, it induces the proliferation of a prostate cell and expression of prostate specific antigen (PSA). Dihydrotestosterone 0-3 androgen receptor Rattus norvegicus 16-33 33513940-13 2021 In F1:Fin rats the serum levels of T and DHT negatively correlated with androgen receptor mRNA. Dihydrotestosterone 41-44 androgen receptor Rattus norvegicus 72-89 33340384-12 2021 In addition, immunohistochemistry revealed that DHT treatment of GDX animals rapidly increased the number of cell bodies in the NAcSh positive for phosphorylated cAMP response-element binding protein, a downstream messenger of the androgen receptor. Dihydrotestosterone 48-51 androgen receptor Rattus norvegicus 231-248 30641088-5 2019 Treatment of primary neonatal rat ventricular cardiomyocytes (NRCMs) and H9c2 cells with DHT significantly increased cell size and upregulated PKCdelta expression, which could be attenuated by AR antagonist. Dihydrotestosterone 89-92 androgen receptor Rattus norvegicus 193-195 30568634-8 2018 Results: AR is expressed in the nucleus of mesenchymal core, tip and cord cells of the embryonic (E) day 17 and 21 fetal gubernaculum, and is enhanced by DHT in primary cultures of gubernacular mesenchymal cells. Dihydrotestosterone 154-157 androgen receptor Rattus norvegicus 9-11 30568634-13 2018 DHT enhanced cellular AR expression but had no major effects on muscle morphology or matrix composition in the rat fetal gubernaculum in vitro. Dihydrotestosterone 0-3 androgen receptor Rattus norvegicus 22-24 29444261-2 2018 In the prostate cancer (PC) cell line LNCaP, S42 did not induce AR transactivation but antagonized 5alpha-dihydrotestosterone (DHT)-induced AR activation. Dihydrotestosterone 99-125 androgen receptor Rattus norvegicus 140-142 29444261-2 2018 In the prostate cancer (PC) cell line LNCaP, S42 did not induce AR transactivation but antagonized 5alpha-dihydrotestosterone (DHT)-induced AR activation. Dihydrotestosterone 127-130 androgen receptor Rattus norvegicus 140-142 29444261-9 2018 DHT also significantly upregulated AR, insulinlike growth factor-1 receptor (IGF-1R), and insulin receptor (IR)-beta protein levels, which were similarly reduced by S42 treatment. Dihydrotestosterone 0-3 androgen receptor Rattus norvegicus 35-37