PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12767274-6 2003 Insulin-like growth factor-I (IGF-I), which has been shown to activate AR in the absence of ligand, did not activate PSA secretion in the absence of androgen, but further increased the dihydrotestosterone-induced PSA secretion in PC-3(AR) cells. Dihydrotestosterone 185-204 insulin like growth factor 1 Homo sapiens 30-35 12767274-6 2003 Insulin-like growth factor-I (IGF-I), which has been shown to activate AR in the absence of ligand, did not activate PSA secretion in the absence of androgen, but further increased the dihydrotestosterone-induced PSA secretion in PC-3(AR) cells. Dihydrotestosterone 185-204 insulin like growth factor 1 Homo sapiens 0-28 14973257-3 2004 We examined the in vitro effect of dihydrotestosterone (DHT) on DNA synthesis and progesterone secretion by follicular cells in response to FSH and IGF-I, alone or in combination. Dihydrotestosterone 35-54 insulin like growth factor 1 Homo sapiens 148-153 14973257-3 2004 We examined the in vitro effect of dihydrotestosterone (DHT) on DNA synthesis and progesterone secretion by follicular cells in response to FSH and IGF-I, alone or in combination. Dihydrotestosterone 56-59 insulin like growth factor 1 Homo sapiens 148-153 14973257-7 2004 The effects of DHT on proliferative responses of COCs were also dependent on follicle size: DHT significantly augmented either IGF-I-stimulated proliferation (1- to 3-mm follicles) or FSH-stimulated proliferation (3- to 5-mm follicles). Dihydrotestosterone 92-95 insulin like growth factor 1 Homo sapiens 127-132 10579321-3 1999 The nonaromatizable androgen, 5alpha-dihydrotestosterone (5alphaDHT), and testosterone, but not dehydroepiandrosterone, increased IGF-I messenger RNA (mRNA) levels up to 4-fold in a dose (10(-12)-10(-6) M)- and time (2-72 h)-dependent fashion. Dihydrotestosterone 30-56 insulin like growth factor 1 Homo sapiens 130-135 12213870-9 2002 In conclusion, short-term GH and IGF-I suppression after surgery or LAN significantly increased T and DHT levels and improved sperm number and motility in acromegalic men. Dihydrotestosterone 102-105 insulin like growth factor 1 Homo sapiens 33-38 10579321-3 1999 The nonaromatizable androgen, 5alpha-dihydrotestosterone (5alphaDHT), and testosterone, but not dehydroepiandrosterone, increased IGF-I messenger RNA (mRNA) levels up to 4-fold in a dose (10(-12)-10(-6) M)- and time (2-72 h)-dependent fashion. Dihydrotestosterone 58-67 insulin like growth factor 1 Homo sapiens 130-135 26187065-2 2015 Here we show that IGF-I gene promoter activity in prostaglandin E2 (PGE2) induced osteoblasts is suppressed by dihydrotestosterone (DHT) through an essential C/EBP response element (RE) in exon 1 of the igf1 gene. Dihydrotestosterone 111-130 insulin like growth factor 1 Homo sapiens 18-23 29472733-8 2017 The mRNA expression of AR and IGF-I and the phosphorylation of mTOR, p70S6K, and 4EBP1 were significantly increased in DHT+SED and SHAM+EX and were significantly enhanced in DHT+EX compared with either DHT or exercise alone. Dihydrotestosterone 119-122 insulin like growth factor 1 Homo sapiens 30-35 29472733-8 2017 The mRNA expression of AR and IGF-I and the phosphorylation of mTOR, p70S6K, and 4EBP1 were significantly increased in DHT+SED and SHAM+EX and were significantly enhanced in DHT+EX compared with either DHT or exercise alone. Dihydrotestosterone 174-177 insulin like growth factor 1 Homo sapiens 30-35 29472733-8 2017 The mRNA expression of AR and IGF-I and the phosphorylation of mTOR, p70S6K, and 4EBP1 were significantly increased in DHT+SED and SHAM+EX and were significantly enhanced in DHT+EX compared with either DHT or exercise alone. Dihydrotestosterone 174-177 insulin like growth factor 1 Homo sapiens 30-35 26187065-10 2015 Thus DHT suppresses the PGE2 and TGF-beta induced IGF-I gene promoter and differentiates other aspects of TGF-beta activity in osteoblasts. Dihydrotestosterone 5-8 insulin like growth factor 1 Homo sapiens 50-55 8969286-8 1996 DHT treatment resulted in a small decrease of mean GH from 4.3 to 2.9 microg/L (P < .025) and of IGF-I from 29.4 to 27.2 nmol/L (nonsignificant [NS]). Dihydrotestosterone 0-3 insulin like growth factor 1 Homo sapiens 100-105 8344190-7 1993 Addition of a monoclonal antibody against IGF-I significantly reduced the effect of DHT, and simultaneous addition of a specific IGF-I receptor antibody blocked the expected induction of 5 alpha R activity (control, 4.9 +/- 0.5; DHT, 8.0 +/- 1.9; DHT plus IGF-I receptor antibody, 3.7 +/- 0.4%). Dihydrotestosterone 84-87 insulin like growth factor 1 Homo sapiens 42-47 8344190-9 1993 These studies indicate that IGF-I may be an important regulator of skin 5 alpha R activity and, thus, may influence DHT formation. Dihydrotestosterone 116-119 insulin like growth factor 1 Homo sapiens 28-33 8473416-0 1993 Androgen-stimulated pubertal growth: the effects of testosterone and dihydrotestosterone on growth hormone and insulin-like growth factor-I in the treatment of short stature and delayed puberty. Dihydrotestosterone 69-88 insulin like growth factor 1 Homo sapiens 111-139 8488157-3 1993 However, in the presence of dihydrotestosterone (DHT), DNA synthesis of LNCaP cells was stimulated by IGF-I in a dose-dependent manner. Dihydrotestosterone 28-47 insulin like growth factor 1 Homo sapiens 102-107 8488157-3 1993 However, in the presence of dihydrotestosterone (DHT), DNA synthesis of LNCaP cells was stimulated by IGF-I in a dose-dependent manner. Dihydrotestosterone 49-52 insulin like growth factor 1 Homo sapiens 102-107 2229290-6 1990 We found that dihydrotestosterone (DHT) treatment enhanced the mitogenic effects of fibroblast growth factor (FGF) and IGF-II but not those of IGF-I. Dihydrotestosterone 14-33 insulin like growth factor 1 Homo sapiens 119-124 2229290-6 1990 We found that dihydrotestosterone (DHT) treatment enhanced the mitogenic effects of fibroblast growth factor (FGF) and IGF-II but not those of IGF-I. Dihydrotestosterone 35-38 insulin like growth factor 1 Homo sapiens 119-124 26187065-2 2015 Here we show that IGF-I gene promoter activity in prostaglandin E2 (PGE2) induced osteoblasts is suppressed by dihydrotestosterone (DHT) through an essential C/EBP response element (RE) in exon 1 of the igf1 gene. Dihydrotestosterone 111-130 insulin like growth factor 1 Homo sapiens 203-207 26187065-2 2015 Here we show that IGF-I gene promoter activity in prostaglandin E2 (PGE2) induced osteoblasts is suppressed by dihydrotestosterone (DHT) through an essential C/EBP response element (RE) in exon 1 of the igf1 gene. Dihydrotestosterone 132-135 insulin like growth factor 1 Homo sapiens 18-23 26187065-2 2015 Here we show that IGF-I gene promoter activity in prostaglandin E2 (PGE2) induced osteoblasts is suppressed by dihydrotestosterone (DHT) through an essential C/EBP response element (RE) in exon 1 of the igf1 gene. Dihydrotestosterone 132-135 insulin like growth factor 1 Homo sapiens 203-207 26187065-5 2015 Inhibition by DHT persists when upstream Smad and Runx REs in the IGF-I gene promoter are mutated. Dihydrotestosterone 14-17 insulin like growth factor 1 Homo sapiens 66-71 26187065-7 2015 Still, DHT suppresses TGF-beta induced IGF-I promoter activity, but not its effects on DNA or collagen synthesis. Dihydrotestosterone 7-10 insulin like growth factor 1 Homo sapiens 39-44 25669835-3 2015 Previously, we demonstrated in human peripheral blood lymphocytes that high doses of anabolic androgenic steroids, such as dihydrotestosterone (DHT) and growth factors, such as insulin-like growth factor-1 (IGF-1), have effects at gene and protein levels. Dihydrotestosterone 123-142 insulin like growth factor 1 Homo sapiens 207-212 25669835-3 2015 Previously, we demonstrated in human peripheral blood lymphocytes that high doses of anabolic androgenic steroids, such as dihydrotestosterone (DHT) and growth factors, such as insulin-like growth factor-1 (IGF-1), have effects at gene and protein levels. Dihydrotestosterone 144-147 insulin like growth factor 1 Homo sapiens 207-212 18280909-1 2008 Acne is caused by the action of dihydrotestosterone, derived from endogenous and exogenous precursors, likely acting synergistically with insulin-like growth factor-1. Dihydrotestosterone 32-51 insulin like growth factor 1 Homo sapiens 138-166 24152843-2 2013 First, to obtain a gene signature, we treated cultures of lymphocytes from sedentary males with three doses of 0.237 microg/ml DHT, each of which is 80-fold the physiological concentration in young adult male serum, at days 0, 2 and 4, or with a single dose of 1.25 microg/ml IGF-1, which is 5-fold the physiological concentration in young adult male serum. Dihydrotestosterone 127-130 insulin like growth factor 1 Homo sapiens 276-281 24152843-7 2013 We identified six (IDO1, CXCL13, CCL1, GZMB, VDR and IL2RA) and two (FN1 and RAB31) genes that were up-regulated in lymphocytes from sedentary subjects after 7 days of DHT and IGF-1 treatment, respectively. Dihydrotestosterone 168-171 insulin like growth factor 1 Homo sapiens 176-181 21765438-7 2011 With increasing concentrations of DHT, insulin-like growth factor-1 (IGF-1) secretion increased in PZsc but decreased in TZsc. Dihydrotestosterone 34-37 insulin like growth factor 1 Homo sapiens 39-67 21765438-7 2011 With increasing concentrations of DHT, insulin-like growth factor-1 (IGF-1) secretion increased in PZsc but decreased in TZsc. Dihydrotestosterone 34-37 insulin like growth factor 1 Homo sapiens 69-74 21471532-3 2011 MATERIALS AND METHODS: The expression of the IGF-1 system was characterized in human HLE-B3 lens epithelium cells and the mitogenic activity of IGF-1 and synthetic E peptide and the effects of growth hormone (GH) and dihydrotestosterone (DHT) were examined, using qualitative real-time PCR, RT-PCR, Western blot analysis and trypan blue exclusion assays in wild-type and IGF-1R knock-out HLE-B3 cells. Dihydrotestosterone 217-236 insulin like growth factor 1 Homo sapiens 45-50 21471532-3 2011 MATERIALS AND METHODS: The expression of the IGF-1 system was characterized in human HLE-B3 lens epithelium cells and the mitogenic activity of IGF-1 and synthetic E peptide and the effects of growth hormone (GH) and dihydrotestosterone (DHT) were examined, using qualitative real-time PCR, RT-PCR, Western blot analysis and trypan blue exclusion assays in wild-type and IGF-1R knock-out HLE-B3 cells. Dihydrotestosterone 238-241 insulin like growth factor 1 Homo sapiens 45-50 18521741-3 2009 Here we demonstrate that an AR ligand, 5-alpha-dihydrotestosterone (DHT), inhibits MCF-7 breast cancer cell growth induced by insulin like growth factor 1 (IGF-I). Dihydrotestosterone 39-66 insulin like growth factor 1 Homo sapiens 126-154 18521741-3 2009 Here we demonstrate that an AR ligand, 5-alpha-dihydrotestosterone (DHT), inhibits MCF-7 breast cancer cell growth induced by insulin like growth factor 1 (IGF-I). Dihydrotestosterone 39-66 insulin like growth factor 1 Homo sapiens 156-161 18521741-3 2009 Here we demonstrate that an AR ligand, 5-alpha-dihydrotestosterone (DHT), inhibits MCF-7 breast cancer cell growth induced by insulin like growth factor 1 (IGF-I). Dihydrotestosterone 68-71 insulin like growth factor 1 Homo sapiens 126-154 18521741-3 2009 Here we demonstrate that an AR ligand, 5-alpha-dihydrotestosterone (DHT), inhibits MCF-7 breast cancer cell growth induced by insulin like growth factor 1 (IGF-I). Dihydrotestosterone 68-71 insulin like growth factor 1 Homo sapiens 156-161 21338237-3 2010 Low concentrations of DHT, estrone and flutamide increased the expression of AR and IGF-1, especially estrone, with concentration and time dependence. Dihydrotestosterone 22-25 insulin like growth factor 1 Homo sapiens 84-89 21338237-5 2010 The results indicated expression of AR and IGF-1 genes to be influenced by DHT, estrone and flutamide in LNCaP cells, regulated by multiple signal pathways. Dihydrotestosterone 75-78 insulin like growth factor 1 Homo sapiens 43-48 18283040-0 2008 Lycopene inhibits IGF-I signal transduction and growth in normal prostate epithelial cells by decreasing DHT-modulated IGF-I production in co-cultured reactive stromal cells. Dihydrotestosterone 105-108 insulin like growth factor 1 Homo sapiens 18-23 18283040-0 2008 Lycopene inhibits IGF-I signal transduction and growth in normal prostate epithelial cells by decreasing DHT-modulated IGF-I production in co-cultured reactive stromal cells. Dihydrotestosterone 105-108 insulin like growth factor 1 Homo sapiens 119-124 18283040-3 2008 Dihydrotestosterone (DHT) stimulates insulin-like growth factor-I (IGF-I) production by 6S but not PSRC cells. Dihydrotestosterone 0-19 insulin like growth factor 1 Homo sapiens 37-65 18283040-3 2008 Dihydrotestosterone (DHT) stimulates insulin-like growth factor-I (IGF-I) production by 6S but not PSRC cells. Dihydrotestosterone 0-19 insulin like growth factor 1 Homo sapiens 67-72 18283040-3 2008 Dihydrotestosterone (DHT) stimulates insulin-like growth factor-I (IGF-I) production by 6S but not PSRC cells. Dihydrotestosterone 21-24 insulin like growth factor 1 Homo sapiens 37-65 18283040-3 2008 Dihydrotestosterone (DHT) stimulates insulin-like growth factor-I (IGF-I) production by 6S but not PSRC cells. Dihydrotestosterone 21-24 insulin like growth factor 1 Homo sapiens 67-72 18283040-9 2008 DHT blocked CM-induced, IGF-I-mediated, NPE death in co-cultured NPE/6S cells without, but not with, added anti-IGF-I and anti-IGF-R antibodies. Dihydrotestosterone 0-3 insulin like growth factor 1 Homo sapiens 24-29 16368782-9 2006 The effects of DHT on IGF-I, IGFBP-2, and IGFBP-3 were more pronounced in stromal cultures that did not express desmin. Dihydrotestosterone 15-18 insulin like growth factor 1 Homo sapiens 22-27 15368471-8 2004 IGF-I significantly enhanced dihydrotestosterone (DHT)-stimulated, but not basal, AR transcriptional activity in PRI cells. Dihydrotestosterone 29-48 insulin like growth factor 1 Homo sapiens 0-5 16368782-0 2006 DHT and testosterone, but not DHEA or E2, differentially modulate IGF-I, IGFBP-2, and IGFBP-3 in human prostatic stromal cells. Dihydrotestosterone 0-3 insulin like growth factor 1 Homo sapiens 66-71 16368782-5 2006 DHT and T each increased IGF-I (7-fold) and decreased IGFBP-3 (2-fold) mRNA expression and protein secretion in a dose- and time-dependent manner and increased IGFBP-2 (2-fold) mRNA in a dose- and time-dependent manner. Dihydrotestosterone 0-3 insulin like growth factor 1 Homo sapiens 25-30 16368782-7 2006 Flutamide abolished the DHT-modulated increases in IGF-I and IGFBP-2, suggesting that the influences of DHT and T on these measures were androgen receptor mediated. Dihydrotestosterone 24-27 insulin like growth factor 1 Homo sapiens 51-56 15781674-15 2005 In women with clinical acne, IGF-1 correlated with DHT. Dihydrotestosterone 51-54 insulin like growth factor 1 Homo sapiens 29-34 15368471-8 2004 IGF-I significantly enhanced dihydrotestosterone (DHT)-stimulated, but not basal, AR transcriptional activity in PRI cells. Dihydrotestosterone 50-53 insulin like growth factor 1 Homo sapiens 0-5 15368471-9 2004 In MET cells, IGF-I significantly suppressed DHT-stimulated transcriptional activity. Dihydrotestosterone 45-48 insulin like growth factor 1 Homo sapiens 14-19 15368471-10 2004 In MET cells in which the IGF-IR was re-expressed from a retroviral vector, the effects of DHT and IGF-I on AR activity were similar to those seen in PRI cells. Dihydrotestosterone 91-94 insulin like growth factor 1 Homo sapiens 26-31