PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23999854-8 2014 The concentrations of testosterone and dihydrotestosterone are significantly reduced after treatment with both LHRH agonists and GnRH antagonists. Dihydrotestosterone 39-58 gonadotropin releasing hormone 1 Homo sapiens 111-115 24316094-11 2014 Also, gonadotropin-releasing hormone antagonist exposure decreased Pde5a expression and dihydrotestosterone co-administration mitigated the decrease. Dihydrotestosterone 88-107 gonadotropin releasing hormone 1 Homo sapiens 6-36 10077358-5 1999 In all subjects under GnRH antagonist treatment a marked suppression of LH, FSH, testosterone, DHT and estradiol was observed. Dihydrotestosterone 95-98 gonadotropin releasing hormone 1 Homo sapiens 22-26 17604502-2 2007 The effect of LHRH agonists is based on the continuous binding to the LHRH receptor (LHRH-R) on the gonadotrope cells of the pituitary, which although initially stimulate LH release, consequently downregulates the LHRH-R, thereby suppressing serum LH, testosterone levels and 5alpha-dihydrotestosterone levels. Dihydrotestosterone 276-302 gonadotropin releasing hormone 1 Homo sapiens 14-18 17604502-2 2007 The effect of LHRH agonists is based on the continuous binding to the LHRH receptor (LHRH-R) on the gonadotrope cells of the pituitary, which although initially stimulate LH release, consequently downregulates the LHRH-R, thereby suppressing serum LH, testosterone levels and 5alpha-dihydrotestosterone levels. Dihydrotestosterone 276-302 gonadotropin releasing hormone 1 Homo sapiens 70-74 17931384-11 2009 During treatment with GnRH+DHT, plasma DHT levels increased up to 16.8 +/- 2.5 nm, while plasma hormone levels, B/I LH ratio, LH pulse amplitude and frequency were similar to those obtained with GnRH alone. Dihydrotestosterone 39-42 gonadotropin releasing hormone 1 Homo sapiens 22-26 19040620-0 2009 Dihydrotestosterone and leptin regulate gonadotropin-releasing hormone (GnRH) expression and secretion in human GnRH-secreting neuroblasts. Dihydrotestosterone 0-19 gonadotropin releasing hormone 1 Homo sapiens 40-70 19040620-0 2009 Dihydrotestosterone and leptin regulate gonadotropin-releasing hormone (GnRH) expression and secretion in human GnRH-secreting neuroblasts. Dihydrotestosterone 0-19 gonadotropin releasing hormone 1 Homo sapiens 72-76 19040620-0 2009 Dihydrotestosterone and leptin regulate gonadotropin-releasing hormone (GnRH) expression and secretion in human GnRH-secreting neuroblasts. Dihydrotestosterone 0-19 gonadotropin releasing hormone 1 Homo sapiens 112-116 19040620-7 2009 RESULTS: Exposure to increasing concentrations of DHT after 24 hours significantly stimulated GnRH mRNA in FNC-B4. Dihydrotestosterone 50-53 gonadotropin releasing hormone 1 Homo sapiens 94-98 19040620-11 2009 Coincubation for 48 hours with leptin and DHT maintained the stimulatory effect on both GnRH and LEPR mRNA, suggesting that DHT could stabilize the leptin effect by preventing downregulation of LEPR. Dihydrotestosterone 42-45 gonadotropin releasing hormone 1 Homo sapiens 88-92 19040620-11 2009 Coincubation for 48 hours with leptin and DHT maintained the stimulatory effect on both GnRH and LEPR mRNA, suggesting that DHT could stabilize the leptin effect by preventing downregulation of LEPR. Dihydrotestosterone 124-127 gonadotropin releasing hormone 1 Homo sapiens 88-92 19040620-13 2009 Moreover, both DHT and leptin increased GnRH release into the culture medium. Dihydrotestosterone 15-18 gonadotropin releasing hormone 1 Homo sapiens 40-44 19040620-15 2009 As we previously found that GnRH stimulates FNC-B4 migration, we hypothesized that this effect could be mediated by DHT- and leptin-induced GnRH release. Dihydrotestosterone 116-119 gonadotropin releasing hormone 1 Homo sapiens 28-32 19040620-15 2009 As we previously found that GnRH stimulates FNC-B4 migration, we hypothesized that this effect could be mediated by DHT- and leptin-induced GnRH release. Dihydrotestosterone 116-119 gonadotropin releasing hormone 1 Homo sapiens 140-144 19040620-16 2009 Accordingly, the GnRH antagonist cetrorelix inhibited DHT- and leptin-induced migration. Dihydrotestosterone 54-57 gonadotropin releasing hormone 1 Homo sapiens 17-21 3931708-0 1985 Effects of intermittent pulsatile infusion of luteinizing hormone-releasing hormone on dihydrotestosterone-suppressed gonadotropin secretion in castrate rams. Dihydrotestosterone 87-106 gonadotropin releasing hormone 1 Homo sapiens 46-83 1702565-3 1991 We have come a long way from surgical castration, through the administration of hormones such as estrogen and progesterone, gonadotropin-releasing hormone agonists to the inhibition of an enzymatic reaction reducing testosterone to DHT--the now recognized active intracellular androgen metabolite. Dihydrotestosterone 232-235 gonadotropin releasing hormone 1 Homo sapiens 124-154 2465302-9 1989 We conclude that pharmacological castration resulting from 3-month treatment with a long-acting GnRH agonist decreases the intraprostatic T concentration to about one fourth and those of DHT and 3 alpha-diol to about one tenth of the levels in untreated men. Dihydrotestosterone 187-190 gonadotropin releasing hormone 1 Homo sapiens 96-100 3082376-7 1986 Relative to the pretreatment GnRH injection, mares treated with T or DHT+P secreted approximately 65% more (p less than 0.01) FSH in response to the post-treatment GnRH injection; FSH response to the second GnRH injection was not altered (p greater than 0.10) in control mares or in DHT- or P-treated mares. Dihydrotestosterone 69-72 gonadotropin releasing hormone 1 Homo sapiens 164-168 3082376-7 1986 Relative to the pretreatment GnRH injection, mares treated with T or DHT+P secreted approximately 65% more (p less than 0.01) FSH in response to the post-treatment GnRH injection; FSH response to the second GnRH injection was not altered (p greater than 0.10) in control mares or in DHT- or P-treated mares. Dihydrotestosterone 69-72 gonadotropin releasing hormone 1 Homo sapiens 164-168 3931708-5 1985 Dihydrotestosterone-implanted wethers given repeated LHRH injections beginning at the time of castration increased serum FSH and yielded LH pulses that were temporally coupled to exogenous LHRH administration. Dihydrotestosterone 0-19 gonadotropin releasing hormone 1 Homo sapiens 189-193 3931708-5 1985 Dihydrotestosterone-implanted wethers given repeated LHRH injections beginning at the time of castration increased serum FSH and yielded LH pulses that were temporally coupled to exogenous LHRH administration. Dihydrotestosterone 0-19 gonadotropin releasing hormone 1 Homo sapiens 53-57 1093346-0 1975 Effects of dihydrotestosterone on LH release induced by LH-RH in men. Dihydrotestosterone 11-30 gonadotropin releasing hormone 1 Homo sapiens 56-61 371861-0 1978 Further studies on the effects of dihydrotestosterone on gonadotrophin release induced by LH-RH in men. Dihydrotestosterone 34-53 gonadotropin releasing hormone 1 Homo sapiens 90-95 371861-2 1978 Our results clearly show that DHT at least in pharmacological doses, inhibits directly basal LH-RH and gonadotrophin secretion, without affecting the pulsatile gonadotrophin release or impairing the pituitary response to LH-RH. Dihydrotestosterone 30-33 gonadotropin releasing hormone 1 Homo sapiens 93-98 371861-2 1978 Our results clearly show that DHT at least in pharmacological doses, inhibits directly basal LH-RH and gonadotrophin secretion, without affecting the pulsatile gonadotrophin release or impairing the pituitary response to LH-RH. Dihydrotestosterone 30-33 gonadotropin releasing hormone 1 Homo sapiens 221-226 6411995-3 1983 The same LHRH agonist administered to adult men with cancer of the prostate causes a marked inhibition of serum testosterone and dihydrotestosterone to castration levels within 1-2 weeks. Dihydrotestosterone 129-148 gonadotropin releasing hormone 1 Homo sapiens 9-13 335574-4 1977 Basal plasma E2, E1, T, DHT, DHA and DHAS concentrations significantly correlated with the releasable pool of LH evoked by Gn-RH from the pituitary gonadotropes. Dihydrotestosterone 24-27 gonadotropin releasing hormone 1 Homo sapiens 123-128 1093346-3 1975 Our results clearly show that the pituitary LH release by LH-RH after pre-treatment with 5alpha-DHT is more prononeced. Dihydrotestosterone 89-99 gonadotropin releasing hormone 1 Homo sapiens 58-63 28925899-5 2017 Chemical castration by gonadotropin-releasing hormone agonists suppresses lutenizing hormone production, which in turn inhibits the production of testosterone and dihydrotestosterone. Dihydrotestosterone 163-182 gonadotropin releasing hormone 1 Homo sapiens 23-53