PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32845149-2 2020 In particular, monoamine oxidase A (MAO A) is an important flavoenzyme involved in the metabolism of monoamine neurotransmitters. monoamine 15-24 monoamine oxidase A Homo sapiens 36-41 32493193-2 2020 The two isoforms of the MAO enzymes, MAO-A and MAO-B are responsible of the degradation of monoamine neurotransmitters and due to this, relevant efforts have been devoted to find new compounds with more selectivity and less side effects. monoamine 91-100 monoamine oxidase A Homo sapiens 37-42 32316576-1 2020 Monoamine oxidases (MAOs) including MAOA and MAOB are enzymes located on the outer membranes of mitochondria, which are responsible for catalyzing monoamine oxidation. monoamine 147-156 monoamine oxidase A Homo sapiens 36-40 33015076-6 2020 The metabolic enzyme for the monoamine neurotransmitters, monoamine oxidases A/B (MAO A/MAO B) are the prime candidates for the investigation into the role of DNA methylation in mental disorders. monoamine 29-38 monoamine oxidase A Homo sapiens 58-80 33015076-6 2020 The metabolic enzyme for the monoamine neurotransmitters, monoamine oxidases A/B (MAO A/MAO B) are the prime candidates for the investigation into the role of DNA methylation in mental disorders. monoamine 29-38 monoamine oxidase A Homo sapiens 82-93 30271325-1 2018 Monoamine oxidase A (MAO-A) is an enzyme that regulates the levels of monoamine neurotransmitters, such as serotonin, noradrenaline and dopamine and it has been used as a therapeutic target for depression. monoamine 70-79 monoamine oxidase A Homo sapiens 0-19 31322459-7 2020 Glucocorticoids and glucocorticoid-metabolizing enzymes interact closely with other biomolecules such as inflammatory cytokines, monoamines, and some monoamine-metabolizing enzymes, namely the monoamine oxidase type A (MAO-A) and B (MAO-B). monoamine 129-138 monoamine oxidase A Homo sapiens 193-217 31322459-7 2020 Glucocorticoids and glucocorticoid-metabolizing enzymes interact closely with other biomolecules such as inflammatory cytokines, monoamines, and some monoamine-metabolizing enzymes, namely the monoamine oxidase type A (MAO-A) and B (MAO-B). monoamine 129-138 monoamine oxidase A Homo sapiens 219-231 30849741-10 2019 Moreover, it is possible for BDT to improve PSHS through the functional targets including GLO1, MAOA and MAOB, which are closely related to monoamine neurotransmitters. monoamine 140-149 monoamine oxidase A Homo sapiens 96-100 31140884-1 2019 Aim: Due to the pivotal role in the oxidative deamination of monoamine neurotransmitters, two distinct monoamine oxidase (MAO) subtypes, MAO-A and MAO-B, present a significant pharmacological interest. monoamine 61-70 monoamine oxidase A Homo sapiens 137-142 30456877-1 2019 The monoamine oxidase A (MAOA) enzyme metabolizes monoamine neurotransmitters such as dopamine, serotonin and norepinephrine, and its genetic polymorphism (rs1137070) influences its activity level and is associated with smoking behaviors. monoamine 4-13 monoamine oxidase A Homo sapiens 25-29 30974737-1 2019 Monoamine oxidase A (MAOA) is an important mitochondria-bound enzyme that catalyzes the oxidative deamination of monoamine neurotransmitters. monoamine 113-122 monoamine oxidase A Homo sapiens 0-19 30974737-1 2019 Monoamine oxidase A (MAOA) is an important mitochondria-bound enzyme that catalyzes the oxidative deamination of monoamine neurotransmitters. monoamine 113-122 monoamine oxidase A Homo sapiens 21-25 30271325-1 2018 Monoamine oxidase A (MAO-A) is an enzyme that regulates the levels of monoamine neurotransmitters, such as serotonin, noradrenaline and dopamine and it has been used as a therapeutic target for depression. monoamine 70-79 monoamine oxidase A Homo sapiens 21-26 29671581-1 2018 Monoamine oxidase (MAO) enzymes MAO-A and MAO-B play a critical role in the metabolism of monoamine neurotransmitters. monoamine 90-99 monoamine oxidase A Homo sapiens 32-37 29423903-1 2018 PURPOSE: Inhibition of the isoform A of monoamine oxidase (MAO-A), a mitochondrial enzyme catalyzing deamination of monoamine neurotransmitters, is useful in treatment of depression and anxiety disorders. monoamine 40-49 monoamine oxidase A Homo sapiens 59-64 28293733-1 2018 Type A monoamine oxidase (MAOA) catabolizes monoamine transmitters, serotonin, norepinephrine and dopamine, and plays a major role in the onset, progression and therapy of neuropsychiatric disorders. monoamine 7-16 monoamine oxidase A Homo sapiens 26-30 25074638-3 2015 MAO-A is an enzyme that increases in density after estrogen decline, and has several functions including creating oxidative stress, influencing apoptosis and monoamine metabolism. monoamine 158-167 monoamine oxidase A Homo sapiens 0-5 26871599-3 2016 Monoamine Oxidase A (MAO A) oxidizes monoamine neurotransmitters resulting in reactive oxygen species which cause cancer. monoamine 37-46 monoamine oxidase A Homo sapiens 0-19 26871599-3 2016 Monoamine Oxidase A (MAO A) oxidizes monoamine neurotransmitters resulting in reactive oxygen species which cause cancer. monoamine 37-46 monoamine oxidase A Homo sapiens 21-26 26818237-12 2016 In addition, urine samples from two patients and a heterozygous carrier of a family with disturbed monoamine metabolism due to a loss of function mutation in the MAOA gene (X-linked) were analyzed and compared with samples from controls. monoamine 99-108 monoamine oxidase A Homo sapiens 162-166 25585152-2 2015 Monoamine oxidase A (MAOA), a mitochondria-bound enzyme, degrades monoamine neurotransmitters and dietary monoamines. monoamine 66-75 monoamine oxidase A Homo sapiens 0-19 25585152-2 2015 Monoamine oxidase A (MAOA), a mitochondria-bound enzyme, degrades monoamine neurotransmitters and dietary monoamines. monoamine 66-75 monoamine oxidase A Homo sapiens 21-25 25733484-3 2015 MAOA metabolizes monoamine neurotransmitters. monoamine 17-26 monoamine oxidase A Homo sapiens 0-4 23207409-1 2013 Due to their role in the metabolism of monoamine neurotransmitters, MAO-A and MAO-B present a significant pharmacological interest. monoamine 39-48 monoamine oxidase A Homo sapiens 68-73 24865426-1 2014 Tumors from patients with high-grade aggressive prostate cancer (PCa) exhibit increased expression of monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades monoamine neurotransmitters and dietary amines. monoamine 102-111 monoamine oxidase A Homo sapiens 123-127 24510409-1 2014 Monoamine oxidase A (MAOA) catalyzes monoamine neurotransmitters including dopamine, 5-hydroxytryptamine (5-HT, serotonin), and norepinephrine. monoamine 37-46 monoamine oxidase A Homo sapiens 0-19 24510409-1 2014 Monoamine oxidase A (MAOA) catalyzes monoamine neurotransmitters including dopamine, 5-hydroxytryptamine (5-HT, serotonin), and norepinephrine. monoamine 37-46 monoamine oxidase A Homo sapiens 21-25 24356376-1 2014 Expression levels of monoamine oxidase A (MAOA), the enzyme that related to monoamine neurotransmitters metabolism such as serotonin, are related to schizophrenia and autism spectrum disorder. monoamine 21-30 monoamine oxidase A Homo sapiens 42-46 25073638-4 2014 METHODS: We have searched for association between 119 SNPs in genes implicated in monoaminergic pathways [tryptophan hydroxylase 1 (TPH1), TPH2, tyrosine hydroxylase (TH), DOPA decarboxylase (DDC), dopamine beta-hydroxylase (DBH), catechol-O-methyltransferase (COMT), monoamine oxidase A (MAOA) and MAOB] and monoamine metabolite concentrations in CSF in 74 patients with psychotic disorder. monoamine 82-91 monoamine oxidase A Homo sapiens 268-287 25073638-4 2014 METHODS: We have searched for association between 119 SNPs in genes implicated in monoaminergic pathways [tryptophan hydroxylase 1 (TPH1), TPH2, tyrosine hydroxylase (TH), DOPA decarboxylase (DDC), dopamine beta-hydroxylase (DBH), catechol-O-methyltransferase (COMT), monoamine oxidase A (MAOA) and MAOB] and monoamine metabolite concentrations in CSF in 74 patients with psychotic disorder. monoamine 82-91 monoamine oxidase A Homo sapiens 289-293 23319006-3 2014 Among these, the gene encoding monoamine oxidase A (MAOA) is noteworthy given that genetic variation has been demonstrated to influence gene expression and monoamine levels. monoamine 31-40 monoamine oxidase A Homo sapiens 52-56 22218074-6 2012 Second, measures related to mechanisms of monoamine loss, particularly elevated MAO-A binding in prefrontal and anterior cingulate cortex, are present in MDE and in high-risk states for MDE. monoamine 42-51 monoamine oxidase A Homo sapiens 80-85 22186668-4 2012 These findings suggest an adaptive role for MAO-A in maintaining monoamine neurotransmitter homeostasis by rapidly compensating fluctuating monoamine levels. monoamine 65-74 monoamine oxidase A Homo sapiens 44-49 22890201-2 2012 Both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) regulate neurochemistry by degrading monoamine neurotransmitters (serotonin, dopamine, and norepinephrine). monoamine 5-14 monoamine oxidase A Homo sapiens 26-31 21775495-5 2011 MAO A is a key enzyme that degrades a number of monoamine neurotransmitters, including serotonin. monoamine 48-57 monoamine oxidase A Homo sapiens 0-5 21949471-2 2011 We examined the interaction of a stressor (receipt of public assistance) and a gene regulating the monoamine system (MAOA) in the prediction of change in adolescent depressive symptoms and body mass index (BMI). monoamine 99-108 monoamine oxidase A Homo sapiens 117-121 21761555-1 2011 Monoamine oxidase A (MAOA) plays a critical role in the metabolism of monoamine neurotransmitters including serotonin (5-HT), norepinephrine (NE), and dopamine (DA). monoamine 70-79 monoamine oxidase A Homo sapiens 0-19 21761555-1 2011 Monoamine oxidase A (MAOA) plays a critical role in the metabolism of monoamine neurotransmitters including serotonin (5-HT), norepinephrine (NE), and dopamine (DA). monoamine 70-79 monoamine oxidase A Homo sapiens 21-25 20332182-1 2010 Monoamine oxidase A (MAOA) and the transporters for serotonin (5-HTT) and norepinephrine (NET) may play important roles in regulating maternal monoamine neurotransmitters transferred across the placenta to the fetus. monoamine 143-152 monoamine oxidase A Homo sapiens 0-19 21359973-1 2011 Monoamine oxidase (MAO) A and MAO B are a crucial pair of isoenzymes, which oxidatively deaminate monoamine neurotransmitters and dietary amines with a production of hydrogen peroxide. monoamine 98-107 monoamine oxidase A Homo sapiens 0-25 21079379-6 2011 Therefore, we conclude that orexin-A-induced arousal is dependent upon monoamine neural activities stimulated by MAO-A in chicks. monoamine 71-80 monoamine oxidase A Homo sapiens 113-118 21302344-2 2011 Well-characterized common functional polymorphisms in the genes MAOA, COMT, and 5HTTLPR each have predictable effects on the availability of the monoamine neurotransmitters dopamine, noradrenaline, and serotonin. monoamine 145-154 monoamine oxidase A Homo sapiens 64-68 20332182-1 2010 Monoamine oxidase A (MAOA) and the transporters for serotonin (5-HTT) and norepinephrine (NET) may play important roles in regulating maternal monoamine neurotransmitters transferred across the placenta to the fetus. monoamine 143-152 monoamine oxidase A Homo sapiens 21-25 20332182-9 2010 These findings suggest that the three promoter polymorphisms of MAOA, 5-HTT, and NET influence gene expression levels and protein activity of these genes in human placentas, potentially leading to different fetal levels of maternal monoamine neurotransmitters, which may have an impact on fetal neurodevelopment. monoamine 232-241 monoamine oxidase A Homo sapiens 64-68 19661285-1 2009 Monoamine oxidase A (MAO A), encoded by the X chromosome, catalyzes the oxidative deamination of monoamine neurotransmitters, such as serotonin, and plays a critically important role in brain development and functions. monoamine 97-106 monoamine oxidase A Homo sapiens 0-19 20439828-14 2010 CONCLUSIONS: Elevated MAO-A levels in the early postpartum period can be interpreted as a marker of a monoamine-lowering process that contributes to the mood change of postpartum blues. monoamine 102-111 monoamine oxidase A Homo sapiens 22-27 19996035-13 2009 CONCLUSIONS: Elevated MAO-A binding after SSRI treatment indicates persistence of a monoamine-lowering process not present in health. monoamine 84-93 monoamine oxidase A Homo sapiens 22-27 19996035-15 2009 Greater MAO-A binding in the prefrontal and anterior cingulate cortex in subjects with MDD in recovery and its association with subsequent recurrence argue that deficient monoamine neuromodulation may persist into recovery and contribute to recurrence. monoamine 171-180 monoamine oxidase A Homo sapiens 8-13 19661285-1 2009 Monoamine oxidase A (MAO A), encoded by the X chromosome, catalyzes the oxidative deamination of monoamine neurotransmitters, such as serotonin, and plays a critically important role in brain development and functions. monoamine 97-106 monoamine oxidase A Homo sapiens 21-26 16139427-1 2005 Monoamine oxidase A (MAO-A) is an enzyme involved in the metabolism of monoamine neurotransmitters such as dopamine, serotonin, and noradrenaline in the brain. monoamine 71-80 monoamine oxidase A Homo sapiens 0-19 18463263-1 2008 The genetic deletion of monoamine oxidase A (MAO A), an enzyme that breaks down the monoamine neurotransmitters norepinephrine, serotonin, and dopamine, produces aggressive phenotypes across species. monoamine 24-33 monoamine oxidase A Homo sapiens 45-50 16770335-4 2006 Our goals were to test (1) whether MAOA-LPR contributes to interindividual variation in monoamine activity, assessed using levels of cerebrospinal fluid (CSF) monoamine metabolites; and (2) whether MAOA-LPR genotype influences alcoholism and/or body mass index (BMI). monoamine 88-97 monoamine oxidase A Homo sapiens 35-39 17447416-1 2006 Monoamine oxidases A and B (MAO A and MAO B) are the major enzymes that catalyze the oxidative deamination of monoamine neurotaransmitters such as dopamine (DA), noradrenaline, and serotonin in the central and peripheral nervous systems. monoamine 110-119 monoamine oxidase A Homo sapiens 0-26 17447416-1 2006 Monoamine oxidases A and B (MAO A and MAO B) are the major enzymes that catalyze the oxidative deamination of monoamine neurotaransmitters such as dopamine (DA), noradrenaline, and serotonin in the central and peripheral nervous systems. monoamine 110-119 monoamine oxidase A Homo sapiens 28-43 17447417-2 2006 Monoamine oxidase (MAO) in the mitochondrial outer membrane produces hydrogen peroxide by oxidation of monoamine substrates, and induces oxidative stress resulting in neuronal degeneration. monoamine 103-112 monoamine oxidase A Homo sapiens 19-22 17519928-2 2008 To identify these circuits, we used a combined genetic and imaging approach focused on Monoamine Oxidase A (MAOA), encoding a key enzyme for monoamine metabolism previously associated with temperament and antisocial behavior. monoamine 141-150 monoamine oxidase A Homo sapiens 87-106 17519928-2 2008 To identify these circuits, we used a combined genetic and imaging approach focused on Monoamine Oxidase A (MAOA), encoding a key enzyme for monoamine metabolism previously associated with temperament and antisocial behavior. monoamine 141-150 monoamine oxidase A Homo sapiens 108-112 17088501-11 2006 CONCLUSIONS: The sizable magnitude of this finding and the absence of other compelling explanations for monoamine loss during major depressive episodes led to the conclusion that elevated MAO-A density is the primary monoamine-lowering process during major depression. monoamine 104-113 monoamine oxidase A Homo sapiens 188-193 17088501-11 2006 CONCLUSIONS: The sizable magnitude of this finding and the absence of other compelling explanations for monoamine loss during major depressive episodes led to the conclusion that elevated MAO-A density is the primary monoamine-lowering process during major depression. monoamine 217-226 monoamine oxidase A Homo sapiens 188-193 16770335-2 2006 Monoamine oxidase A deaminates the monoamine neurotransmitters serotonin, dopamine (DA), and noradrenaline. monoamine 35-44 monoamine oxidase A Homo sapiens 0-19 16139427-1 2005 Monoamine oxidase A (MAO-A) is an enzyme involved in the metabolism of monoamine neurotransmitters such as dopamine, serotonin, and noradrenaline in the brain. monoamine 71-80 monoamine oxidase A Homo sapiens 21-26 7519866-5 1994 A physiological pharmacokinetic-pharmacodynamic model was used to describe MAO-A inhibition as reflected in the alterations of monoamine metabolites. monoamine 127-136 monoamine oxidase A Homo sapiens 75-80 11157075-1 2001 Deficiency in the monoamine degradation enzyme monoamine oxidase A (MAOA) or prenatal exposure to the monoamine uptake inhibitor cocaine alters behavior in humans and rodents, but the mechanisms are unclear. monoamine 18-27 monoamine oxidase A Homo sapiens 47-66 11157075-1 2001 Deficiency in the monoamine degradation enzyme monoamine oxidase A (MAOA) or prenatal exposure to the monoamine uptake inhibitor cocaine alters behavior in humans and rodents, but the mechanisms are unclear. monoamine 18-27 monoamine oxidase A Homo sapiens 68-72 11157075-1 2001 Deficiency in the monoamine degradation enzyme monoamine oxidase A (MAOA) or prenatal exposure to the monoamine uptake inhibitor cocaine alters behavior in humans and rodents, but the mechanisms are unclear. monoamine 47-56 monoamine oxidase A Homo sapiens 68-72 10331110-5 1999 In this report, we use 110 nuclear OCD families to analyze the inheritance of variants of COMT and monoamine oxidase-A (MAOA), another gene modulating monoamine metabolism. monoamine 99-108 monoamine oxidase A Homo sapiens 120-124 15694196-2 2005 Monoamine oxidase A and B (MAO-A and -B) regulate the levels of monoamine neurotransmitters, so changes in their activity could participate in migraine pathogenesis. monoamine 64-73 monoamine oxidase A Homo sapiens 0-25 15694196-2 2005 Monoamine oxidase A and B (MAO-A and -B) regulate the levels of monoamine neurotransmitters, so changes in their activity could participate in migraine pathogenesis. monoamine 64-73 monoamine oxidase A Homo sapiens 27-39 15457497-0 2005 Relationship of MAO-A promoter (u-VNTR) and COMT (V158M) gene polymorphisms to CSF monoamine metabolites levels in a psychiatric sample of caucasians: A preliminary report. monoamine 83-92 monoamine oxidase A Homo sapiens 16-21 9564605-1 1998 Lack of monoamine oxidase A (MAO-A) due to either Xp chromosomal deletions or alterations in the coding sequence of the gene for this enzyme are associated with marked changes in monoamine metabolism and appear to be associated with variable cognitive deficits and behavioral changes in humans and in transgenic mice. monoamine 8-17 monoamine oxidase A Homo sapiens 29-34 8695909-1 1996 Bacterial cells respond to monoamine compounds, such as tyramine, dopamine, octopamine, or norepinephrine, and induce the syntheses of tyramine oxidase encoded by tynA and monoamine oxidase encoded by maoA. monoamine 27-36 monoamine oxidase A Homo sapiens 201-205 2366877-4 1990 (4) The results show that a 70% depletion of monoamine content by chemical denervation resulted only in a 23% reduction of MAO-A activity in the renal cortex, whereas MAO-B was unaffected either in the cortical or the medullary zones; in the renal medulla MAO-A activity was not changed by denervation. monoamine 45-54 monoamine oxidase A Homo sapiens 123-128 2366877-4 1990 (4) The results show that a 70% depletion of monoamine content by chemical denervation resulted only in a 23% reduction of MAO-A activity in the renal cortex, whereas MAO-B was unaffected either in the cortical or the medullary zones; in the renal medulla MAO-A activity was not changed by denervation. monoamine 45-54 monoamine oxidase A Homo sapiens 256-261 34952543-1 2021 The monoamine oxidase A (MAO-A) is integral to monoamine metabolism and is thus relevant to the pathophysiology of various neuropsychiatric disorders; however, associated gene-enzyme relations are not well understood. monoamine 47-56 monoamine oxidase A Homo sapiens 4-23 34952543-1 2021 The monoamine oxidase A (MAO-A) is integral to monoamine metabolism and is thus relevant to the pathophysiology of various neuropsychiatric disorders; however, associated gene-enzyme relations are not well understood. monoamine 47-56 monoamine oxidase A Homo sapiens 25-30 34167949-3 2021 Here we report that monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades monoamine neurotransmitters and dietary amines, reciprocally interacts with AR in PC. monoamine 85-94 monoamine oxidase A Homo sapiens 20-39 34167949-3 2021 Here we report that monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades monoamine neurotransmitters and dietary amines, reciprocally interacts with AR in PC. monoamine 85-94 monoamine oxidase A Homo sapiens 41-45