PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7654690-8 1995 In fact, the four new substrates of CYP2C9 described in this study, a carboxylic acid, phenol, and tetrazole derivative, each of which is related to tienilic acid, and the antiinflammatory drug, suprofen (with Km between 12 and 130 microM and kcat between 0.2 and 1.3 min-1), as well as almost all CYP2C9 substrates reported in the literature, exhibit a pKa below 7 (except phenytoin whose pKa is 8.1). Phenol 87-93 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 36-42