PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18381438-0	2008	The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner.	alvocidib	38-50	RAD51 recombinase	Homo sapiens	117-122	
18381438-5	2008	Rad51 bound to p53-Ser(15) within the first 5 hours of combination therapy, and then was transcriptionally suppressed at 24 hours by flavopiridol only in p53+/+ cells.	alvocidib	133-145	RAD51 recombinase	Homo sapiens	0-5	
18381438-9	2008	Because flavopiridol inhibits Cdk9, we found that inhibition of Cdk9 by DRB or by siRNA could recapitulate the flavopiridol effects, with suppression of Rad51 and induction of apoptosis only in p53+/+ cells.	alvocidib	111-123	RAD51 recombinase	Homo sapiens	153-158	
18381438-10	2008	In conclusion, after DNA damage by Topo I poisons, flavopiridol targets homologous recombination through a p53-dependent down-regulation of Rad51, resulting in enhancement of apoptosis.	alvocidib	51-63	RAD51 recombinase	Homo sapiens	140-145