PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3028323-3 1986 The serum paraoxonase genotype has a significant influence on the paraoxon clearance and consequently on the toxic action of paraoxon and some related organophosphates and definitively protects the serum cholinesterase. Paraoxon 10-18 butyrylcholinesterase Homo sapiens 204-218 2731661-9 1989 Mean IC50"s for inhibition of CHE (a marker for occupational exposure to organophosphates and carbamates) by DFP, paraoxon, dichlorvos, carbofuran, and carbaryl were 1.0 X 10(-8), 4.1 X 10(-8), 1.0 X 10(-7), 3.3 X 10(-6), and 1.8 X 10(-5) M, respectively. Paraoxon 114-122 butyrylcholinesterase Homo sapiens 30-33 6141913-1 1984 The inhibition of cholinesterase of human serum by paraoxon can be predicted by a mathematical model which considers two competing reactions for paraoxon: one, the direct interaction with cholinesterase, and the other, enzymatic hydrolysis by paraoxonase. Paraoxon 51-59 butyrylcholinesterase Homo sapiens 18-32 6141913-1 1984 The inhibition of cholinesterase of human serum by paraoxon can be predicted by a mathematical model which considers two competing reactions for paraoxon: one, the direct interaction with cholinesterase, and the other, enzymatic hydrolysis by paraoxonase. Paraoxon 51-59 butyrylcholinesterase Homo sapiens 188-202 6141913-1 1984 The inhibition of cholinesterase of human serum by paraoxon can be predicted by a mathematical model which considers two competing reactions for paraoxon: one, the direct interaction with cholinesterase, and the other, enzymatic hydrolysis by paraoxonase. Paraoxon 145-153 butyrylcholinesterase Homo sapiens 18-32 6141913-1 1984 The inhibition of cholinesterase of human serum by paraoxon can be predicted by a mathematical model which considers two competing reactions for paraoxon: one, the direct interaction with cholinesterase, and the other, enzymatic hydrolysis by paraoxonase. Paraoxon 145-153 butyrylcholinesterase Homo sapiens 188-202 30466052-4 2019 The paper-based platform was employed to detect paraoxon, 2,4-dichlorophenoxyacetic acid, and atrazine by exploiting the capability of these different types of pesticides (i.e. organophosphorus insecticides, phenoxy-acid herbicides, and triazine herbicide) to inhibit butyrylcholinesterase, alkaline phosphatase, and tyrosinase, respectively. Paraoxon 48-56 butyrylcholinesterase Homo sapiens 268-289 6625764-0 1983 Depressor effects, drug concentration and cholinesterase activities in the brain after administration of paraoxon in the cat. Paraoxon 105-113 butyrylcholinesterase Homo sapiens 42-56 7263810-0 1981 Quantitative analysis of the cholinesterase inhibitor paraoxon in brain tissue using high-performance liquid chromatography. Paraoxon 54-62 butyrylcholinesterase Homo sapiens 29-43 13789937-0 1960 Cholinesterase activity of organs from animals poisoned with a potent cholinesterase inhibitor (paroxan). Paraoxon 96-103 butyrylcholinesterase Homo sapiens 0-14 13789937-0 1960 Cholinesterase activity of organs from animals poisoned with a potent cholinesterase inhibitor (paroxan). Paraoxon 96-103 butyrylcholinesterase Homo sapiens 70-84 13825024-0 1959 [Spontaneous reactivation of alkylphosphate-blocked (paraoxon, systox, isosytox) cholinesterase in vitro]. Paraoxon 53-61 butyrylcholinesterase Homo sapiens 81-95 32583098-3 2020 The reactivation was notable for both AChE and BChE inhibited by VX, cyclosarin, sarin and paraoxon, if quinuclidinium compounds contained the benzyl group attached to the quinuclidinium moiety. Paraoxon 91-99 butyrylcholinesterase Homo sapiens 47-51 31276662-0 2019 Reactivation potency of two novel oximes (K456 and K733) against paraoxon-inhibited acetyl and butyrylcholinesterase: In silico and in vitro models. Paraoxon 65-73 butyrylcholinesterase Homo sapiens 95-116 31201777-0 2019 Aerosolized recombinant human butyrylcholinesterase delivered by a nebulizer provides long term protection against inhaled paraoxon in macaques. Paraoxon 123-131 butyrylcholinesterase Homo sapiens 30-51 226468-1 1979 Incubation of the sera of 799 nonrelated persons with paraoxon led to varying degrees of inhibition of the serum cholinesterase (EC 3.1.1.8) with residual activity between 0% and 67.4% of the initial activity. Paraoxon 54-62 butyrylcholinesterase Homo sapiens 113-127 31276662-3 2019 Present study evaluates reactivation potency of two newly developed oximes, K456 and K733, against paraoxon (POX)-inhibited human-RBC-AChE and human-plasma-BChE in comparison to reported reactivator, pralidoxime (2-PAM). Paraoxon 99-107 butyrylcholinesterase Homo sapiens 156-160 24912784-4 2015 The present study was initiated to determine the reactivation kinetics of 31 structurally different bispyridinium oximes with paraoxon-, tabun- and cyclosarin-inhibited human BChE. Paraoxon 126-134 butyrylcholinesterase Homo sapiens 175-179 29735900-0 2018 Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon. Paraoxon 162-170 butyrylcholinesterase Homo sapiens 127-148 28202731-6 2017 MDE-FACS allowed the identification of human butyrylcholinesterase mutants that undergo self-reactivation after inhibition by the organophosphorus agent paraoxon. Paraoxon 153-161 butyrylcholinesterase Homo sapiens 45-66 24912784-6 2015 The generated data indicate that the tested oximes have a low-to-negligible reactivating potency with paraoxon- and tabun-inhibited human BChE. Paraoxon 102-110 butyrylcholinesterase Homo sapiens 138-142 23216060-2 2013 We identified TAB2OH (2-trimethylammonio-6-hydroxybenzaldehyde oxime) as an efficient reactivator of OP-hBChE conjugates formed by the nerve agents VX and cyclosarin, and the pesticide paraoxon. Paraoxon 185-193 butyrylcholinesterase Homo sapiens 104-109 24571195-2 2014 We present here synthesis and initial in vitro characterization of 14 imidazole aldoximes and their structural refinement into three efficient reactivators of human butyrylcholinesterase (hBChE) inhibited covalently by nerve agent OPs, sarin, cyclosarin, VX, and the OP pesticide metabolite, paraoxon. Paraoxon 292-300 butyrylcholinesterase Homo sapiens 188-193 23178380-0 2013 Pulmonary delivery of an aerosolized recombinant human butyrylcholinesterase pretreatment protects against aerosolized paraoxon in macaques. Paraoxon 119-127 butyrylcholinesterase Homo sapiens 55-76 23216060-4 2013 A 3-5-fold enhancement of in vitro reactivation of VX-, cyclosarin- and paraoxon-inhibited hBChE was observed when compared with the commonly used N-methylpyridinium aldoxime reactivator, 2PAM (2-pyridinealdoxime methiodide). Paraoxon 72-80 butyrylcholinesterase Homo sapiens 91-96 23216060-8 2013 The TAB2OH protective indices in therapy of sarin- and paraoxon-exposed mice were enhanced by 30-60% when they were treated with a combination of TAB2OH and sub-stoichiometric hBChE. Paraoxon 55-63 butyrylcholinesterase Homo sapiens 176-181 22444575-6 2012 Using a purified BChE protein, we initially identified the exact phosphorylation site on the serine residue (S198) with a 108 Da modification by both MS/MS and accurately measured parent ion masses and quantified the extent of phosphorylation on S198 following paraoxon treatment to be >99.9%. Paraoxon 261-269 butyrylcholinesterase Homo sapiens 17-21 22444575-1 2012 Paraoxon (diethyl 4-nitrophenyl phosphate) is an active metabolite of the common insecticide parathion and is acutely toxic due to the inhibition of cholinesterase (ChE) activity in the nervous systems. Paraoxon 0-8 butyrylcholinesterase Homo sapiens 149-163 22444575-1 2012 Paraoxon (diethyl 4-nitrophenyl phosphate) is an active metabolite of the common insecticide parathion and is acutely toxic due to the inhibition of cholinesterase (ChE) activity in the nervous systems. Paraoxon 0-8 butyrylcholinesterase Homo sapiens 165-168 22444575-1 2012 Paraoxon (diethyl 4-nitrophenyl phosphate) is an active metabolite of the common insecticide parathion and is acutely toxic due to the inhibition of cholinesterase (ChE) activity in the nervous systems. Paraoxon 10-41 butyrylcholinesterase Homo sapiens 149-163 22444575-1 2012 Paraoxon (diethyl 4-nitrophenyl phosphate) is an active metabolite of the common insecticide parathion and is acutely toxic due to the inhibition of cholinesterase (ChE) activity in the nervous systems. Paraoxon 10-41 butyrylcholinesterase Homo sapiens 165-168 22444575-7 2012 Then, the phosphorylated BChE peptide in paraoxon-treated human plasma following immunoaffinity purification was successfully identified based on the accurate measured mass and retention time information initially obtained from the purified BChE protein. Paraoxon 41-49 butyrylcholinesterase Homo sapiens 25-29 22444575-7 2012 Then, the phosphorylated BChE peptide in paraoxon-treated human plasma following immunoaffinity purification was successfully identified based on the accurate measured mass and retention time information initially obtained from the purified BChE protein. Paraoxon 41-49 butyrylcholinesterase Homo sapiens 241-245 20032868-0 2009 Novel bisquaternary oximes--reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon. Paraoxon 104-112 butyrylcholinesterase Homo sapiens 69-90 21673941-1 2011 We have in vitro tested the ability of common, commercially available, cholinesterase reactivators (pralidoxime, obidoxime, methoxime, trimedoxime and HI-6) to reactivate human acetylcholinesterase (AChE), inhibited by five structurally different organophosphate pesticides and inhibitors (paraoxon, dichlorvos, DFP, leptophos-oxon and methamidophos). Paraoxon 290-298 butyrylcholinesterase Homo sapiens 71-85 20107127-3 2010 Paraoxon, an organophosphate cholinesterase inhibitor, enhanced glutamatergic transmission on hippocampal granule cells synapses by increasing the frequency and amplitude of spontaneous excitatory postsynaptic currents (sEPSCs) in a concentration-dependent fashion. Paraoxon 0-8 butyrylcholinesterase Homo sapiens 29-43 22467030-5 2012 No changes in the ChE-inhibiting activities were observed for carbamate pesticide solutions tested before and after chlorination, but an additive effect showed against ChE when these compounds were mixed with paraoxon in water. Paraoxon 209-217 butyrylcholinesterase Homo sapiens 168-171 20211614-1 2010 Serum albumin displays an esterase activity that is capable of hydrolysing the anti-cholinesterase compounds carbaryl, paraoxon, chlorpyrifos-oxon, diazoxon and O-hexyl, O-2,5-dichlorphenyl phosphoramidate. Paraoxon 119-127 butyrylcholinesterase Homo sapiens 84-98 19487014-5 2009 The ChE loses almost 32.74% activity after 10 min incubation with 1ng mL(-1) paraoxon and 54.62% with 10 microg mL(-1) paraoxon, while the activity that corresponds to 100 microg mL(-1) paraoxon was nearly completely inhibited. Paraoxon 77-85 butyrylcholinesterase Homo sapiens 4-7 19487014-5 2009 The ChE loses almost 32.74% activity after 10 min incubation with 1ng mL(-1) paraoxon and 54.62% with 10 microg mL(-1) paraoxon, while the activity that corresponds to 100 microg mL(-1) paraoxon was nearly completely inhibited. Paraoxon 119-127 butyrylcholinesterase Homo sapiens 4-7 19487014-5 2009 The ChE loses almost 32.74% activity after 10 min incubation with 1ng mL(-1) paraoxon and 54.62% with 10 microg mL(-1) paraoxon, while the activity that corresponds to 100 microg mL(-1) paraoxon was nearly completely inhibited. Paraoxon 119-127 butyrylcholinesterase Homo sapiens 4-7 19371630-0 2009 Toxicodynamic analysis of the combined cholinesterase inhibition by paraoxon and methamidophos in human whole blood. Paraoxon 68-76 butyrylcholinesterase Homo sapiens 39-53 19586353-3 2009 METHODS: Eighteen structurally different oxime reactivators were tested for their in vitro ability to reactivate paraoxon-inhibited human erythrocyte acetylcholinesterase and human plasma butyrylcholinesterase to find out structure-activity relationship within this set of compounds. Paraoxon 113-121 butyrylcholinesterase Homo sapiens 188-209 18617161-0 2008 Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro. Paraoxon 106-114 butyrylcholinesterase Homo sapiens 71-92 18514178-2 2008 Subsequent purification and biochemical analysis revealed that compared to wild-type butyrylcholinesterase, the cocaine hydrolase displayed increased affinity to the organophosphate (OP) pesticides paraoxon (6.8 4x 10(-10)M vs. 1.11 x 10(-8)M) and malaoxon (9.81 x 10(-8)M vs. 5.99 x 10(-7)M). Paraoxon 198-206 butyrylcholinesterase Homo sapiens 85-106 17723768-5 2006 AChE-based biosensors have demonstrated a higher sensitivity towards aldicarb (50% inhibition with 50 ppb) and carbaryl (50% inhibition with 85 ppb) while BChE biosensors have shown a higher affinity towards paraoxon (50% inhibition with 4 ppb) and chlorpyrifos-methyl oxon (50% inhibition with 1 ppb). Paraoxon 208-216 butyrylcholinesterase Homo sapiens 155-159 15669026-12 2005 The protective effect of RAN on cholinesterase could be of practical relevance in the treatment of POX poisoning. Paraoxon 99-102 butyrylcholinesterase Homo sapiens 32-46 16213467-13 2005 Human BChE is irreversibly inhibited by diisopropylfluorophosphate, echothiophate, and paraoxon, but mouse BChE spontaneously reactivates. Paraoxon 87-95 butyrylcholinesterase Homo sapiens 6-10 16956707-5 2006 In vitro, paraoxon inhibited hippocampal cholinesterase and fatty acid amide hydrolase activities, and displaced specific binding to the cannabinoid receptor ligand ([(3)H]CP 55,940) in a concentration-dependent manner. Paraoxon 10-18 butyrylcholinesterase Homo sapiens 41-55 16956707-7 2006 Four hours after dosing, paraoxon (0.4 mg/kg, sc) elicited classical signs of cholinergic toxicity and significantly reduced hippocampal cholinesterase and fatty acid amide hydrolase activities as well as [(3)H]CP 55,940 binding. Paraoxon 25-33 butyrylcholinesterase Homo sapiens 137-151 12629810-3 2000 Electron microscopic study revealed the presence of acetyl and buthyryl cholinesterase in endotheliocytes of mesoappendicular capillaries, the activity of which was completely suppressed by administration of LD50 of phosphacol. Paraoxon 216-226 butyrylcholinesterase Homo sapiens 72-86 21782705-7 2004 In, in vitro experiments polyurethane foam with immobilized active enzyme removed 40% of parathion and 50% of paraoxon inhibitory effect (based on cholinesterase inhibition). Paraoxon 110-118 butyrylcholinesterase Homo sapiens 147-161 12896833-2 2003 The cholinesterase inhibitor paraoxon was immobilized on the sensing surface via a chelate complex as the recognition element. Paraoxon 29-37 butyrylcholinesterase Homo sapiens 4-18 12896833-5 2003 The paraoxon-modified surface thus obtained was applied for the binding of human butyrylcholinesterase (BChE). Paraoxon 4-12 butyrylcholinesterase Homo sapiens 81-102 12896833-5 2003 The paraoxon-modified surface thus obtained was applied for the binding of human butyrylcholinesterase (BChE). Paraoxon 4-12 butyrylcholinesterase Homo sapiens 104-108 12896833-7 2003 In the presence of free inhibitors like diisopropylfluorophosphate (DFP), binding of BChE to the surface-bound paraoxon was decreased. Paraoxon 111-119 butyrylcholinesterase Homo sapiens 85-89 12625227-1 2003 Pesticides, such as parathion, are metabolized by cytochrome p-450 system to paraoxon, which is a potent cholinesterase inhibitor. Paraoxon 77-85 butyrylcholinesterase Homo sapiens 105-119 10794391-1 2000 Butyrylcholinesterase (BChE) scavenges low doses of organophosphorus (for example, paraoxon) and carbamate pesticides (for example, carbaryl) and in this way protects people from the toxic effects of these poisons. Paraoxon 83-91 butyrylcholinesterase Homo sapiens 0-21 10794391-1 2000 Butyrylcholinesterase (BChE) scavenges low doses of organophosphorus (for example, paraoxon) and carbamate pesticides (for example, carbaryl) and in this way protects people from the toxic effects of these poisons. Paraoxon 83-91 butyrylcholinesterase Homo sapiens 23-27 8098250-1 1993 The organophosphate cholinesterase inhibitor paraoxon is hydrolysed by serum paraoxonase/arylesterase. Paraoxon 45-53 butyrylcholinesterase Homo sapiens 20-34 10574691-10 1999 (v) Short-term exposures of free and liposome-encapsulated BChE to the inhibitor paraoxon, generated significant losses in enzyme activity. Paraoxon 81-89 butyrylcholinesterase Homo sapiens 59-63 10574691-11 1999 Residual activities of both BChE formulations dropped considerably over the paraoxon concentration range of 0.02-0.11 microM, down to 3 and 11% for free and liposome-encapsulated enzyme respectively. Paraoxon 76-84 butyrylcholinesterase Homo sapiens 28-32 10513677-0 1999 L-lactate reduces in vitro the inhibition of butyrylcholinesterase (BChE) by paraoxon (E 600). Paraoxon 77-85 butyrylcholinesterase Homo sapiens 45-66 10513677-0 1999 L-lactate reduces in vitro the inhibition of butyrylcholinesterase (BChE) by paraoxon (E 600). Paraoxon 77-85 butyrylcholinesterase Homo sapiens 68-72 10513677-7 1999 In the micro- and millimolar ranges, lactate is able to abolish in vitro the inhibition of BChE by POX in human plasma when added to plasma prior to POX or when incubated with POX prior to addition to plasma. Paraoxon 99-102 butyrylcholinesterase Homo sapiens 91-95 9269878-6 1997 Paraoxon, an inhibitor of all serine esterases including cholinesterase and carboxylesterase, decreased the hydrolysis of tazarotene to tazarotenic acid by 95% in both blood and liver microsomes. Paraoxon 0-8 butyrylcholinesterase Homo sapiens 57-71 9020776-4 1997 Wild-type butyrylcholinesterase was irreversibly inhibited by echothiophate and paraoxon, but G117H regained 100% activity within 2-3 min following reaction with these compounds. Paraoxon 80-88 butyrylcholinesterase Homo sapiens 10-31 2368191-1 1990 The soluble and immobilized cholinesterases (acetyl cholinesterase of human blood erythrocytes (EC 3.1.1.7) and butyryl cholinesterase of equine blood serum, (EC 3.1.1.8] were inactivated by such irreversible inhibitors as diisopropyl fluorophosphate (DFP), O,O-dimethyl-O-(2,2)-dichlorovinyl) phosphate (DDVP), paraoxone, armine. Paraoxon 312-321 butyrylcholinesterase Homo sapiens 28-42