PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25524556-15 2015 We found that 247 Val was correlated with anti-beta2-GPI production in patients with primary APS, and 247 Val may be important for beta2-GPI antigenicity. Valine 18-21 apolipoprotein H Homo sapiens 47-56 25524556-15 2015 We found that 247 Val was correlated with anti-beta2-GPI production in patients with primary APS, and 247 Val may be important for beta2-GPI antigenicity. Valine 106-109 apolipoprotein H Homo sapiens 131-140 22399073-6 2012 Furthermore, a direct comparison between thrombosis-positive and -negative patients also indicated that the Val/Val + Val/Leu and the Val/Val vs. Leu/Leu genotypes of the beta(2)GPI polymorphism were significantly elevated in patients with thrombosis (OR 2.817, 95% CI 1.200-6.610, p = 0.017; OR 3.312, 95% CI 1.338-8.200, p = 0.010, respectively). Valine 108-111 apolipoprotein H Homo sapiens 171-181 15641049-1 2005 OBJECTIVE: To clarify the consequences of the valine/leucine polymorphism at position 247 of the beta(2)-glycoprotein I (beta(2)GPI) gene in patients with antiphospholipid syndrome (APS), by investigating the correlation between genotypes and the presence of anti-beta(2)GPI antibody. Valine 46-52 apolipoprotein H Homo sapiens 121-131 16686261-2 2006 It has been suggested that the common beta2GPI Valine/Leucine247 (Val/Leu247) polymorphism could be found more commonly in APS and might influence the generation of anti-beta2GPI antibodies. Valine 47-53 apolipoprotein H Homo sapiens 38-46 16686261-2 2006 It has been suggested that the common beta2GPI Valine/Leucine247 (Val/Leu247) polymorphism could be found more commonly in APS and might influence the generation of anti-beta2GPI antibodies. Valine 47-53 apolipoprotein H Homo sapiens 170-178 16686261-2 2006 It has been suggested that the common beta2GPI Valine/Leucine247 (Val/Leu247) polymorphism could be found more commonly in APS and might influence the generation of anti-beta2GPI antibodies. Valine 47-50 apolipoprotein H Homo sapiens 38-46 16686261-2 2006 It has been suggested that the common beta2GPI Valine/Leucine247 (Val/Leu247) polymorphism could be found more commonly in APS and might influence the generation of anti-beta2GPI antibodies. Valine 47-50 apolipoprotein H Homo sapiens 170-178 16686261-3 2006 Therefore we studied beta2GPI Val/Leu247 single-nucleotide polymorphism (SNP) by PCR in 338 patients with various autoimmune diseases (46 with secondary and 84 with primary APS) and 147 sex and age-matched healthy controls. Valine 30-33 apolipoprotein H Homo sapiens 21-29 19758193-2 2009 The objectives of this study were to determine a Val/Leu SNP at position 247 of the beta2-GPI gene in Brazilian patients with APS and to compare these data with clinical and laboratory manifestations. Valine 49-52 apolipoprotein H Homo sapiens 84-93 18777117-0 2009 Association between Val/Leu(247) polymorphism of apolipoprotein H and cerebral infarction in a Chinese population. Valine 20-23 apolipoprotein H Homo sapiens 49-65 18777117-7 2009 RESULTS: Our results demonstrated an association between the Val/Leu(247) polymorphism of apoH gene and aPL in CI patients. Valine 61-64 apolipoprotein H Homo sapiens 90-94 16038107-5 2005 Our results demonstrate an association between substitution of Val for Leu at AA247 (L247V) of beta2GPI and both the development of aPL (P = 0.05) and aPL-associated clinical manifestations (P = 0.03) among pediatric patients. Valine 63-66 apolipoprotein H Homo sapiens 95-103 15641049-7 2005 RESULTS: A positive correlation between the Val(247) allele and the presence of anti-beta(2)GPI antibodies was observed in the patient group. Valine 44-47 apolipoprotein H Homo sapiens 85-95 10446865-1 1999 OBJECTIVE: To determine the frequencies at which either a valine or leucine occurs at position 247 in the beta2-glycoprotein I (beta2GPI) gene of normal individuals of the Caucasian, African American, and Asian ethnic groups and to compare these data with those in patients with the antiphospholipid syndrome (APS), with and without anti-beta2GPI antibodies. Valine 58-64 apolipoprotein H Homo sapiens 128-136 10501418-10 1999 In conclusion, the beta2GPI polymorphism, valine/leucine247, is correlated with anti-beta2GPI antibody production in patients with primary APS, and valine247 may be important in the formation of beta2GPI antigenicity. Valine 42-48 apolipoprotein H Homo sapiens 19-27 10501418-10 1999 In conclusion, the beta2GPI polymorphism, valine/leucine247, is correlated with anti-beta2GPI antibody production in patients with primary APS, and valine247 may be important in the formation of beta2GPI antigenicity. Valine 42-48 apolipoprotein H Homo sapiens 85-93 10501418-10 1999 In conclusion, the beta2GPI polymorphism, valine/leucine247, is correlated with anti-beta2GPI antibody production in patients with primary APS, and valine247 may be important in the formation of beta2GPI antigenicity. Valine 42-48 apolipoprotein H Homo sapiens 85-93