PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29066943-2 2017 We have previously demonstrated that spliceosome-mediated trans-splicing is a viable molecular strategy to specifically reduce and repair mutant HTT (mtHTT). mthtt 150-155 huntingtin Homo sapiens 145-148 23966247-7 2013 CONCLUSIONS: The HTRF assay can effectively measure mtHtt in multicenter sample sets and may be useful in trials of therapies targeting huntingtin. mthtt 52-57 huntingtin Homo sapiens 136-146 22722716-10 2012 DMSO reduced not only soluble but also insoluble mtHTT (mutant huntingtin aggregates) expressions, which were masked in the presence of autophagy inhibitor. mthtt 49-54 huntingtin Homo sapiens 63-73 22415443-6 2012 3-nitropropionic acid, on the aggregation of mutant huntingtin (mthtt) protein, whose misfolding and aggregation results in cellular abnormalities characteristic of HD. mthtt 64-69 huntingtin Homo sapiens 52-62 18951640-4 2008 Here, we highlight how mutant huntingtin (mtHtt) might cause mitochondrial dysfunction by either perturbing transcription of nuclear-encoded mitochondrial proteins or by direct interaction with the organelle and modulation of respiration, mitochondrial membrane potential and Ca(2+) buffering. mthtt 42-47 huntingtin Homo sapiens 30-40 21278900-1 2010 A means for measuring levels of soluble huntingtin proteins in clinical samples is essential for assessing the biological effects of potential mutant huntingtin (mtHtt) modifying treatments being developed for Huntington"s disease (HD). mthtt 162-167 huntingtin Homo sapiens 40-50 21278900-1 2010 A means for measuring levels of soluble huntingtin proteins in clinical samples is essential for assessing the biological effects of potential mutant huntingtin (mtHtt) modifying treatments being developed for Huntington"s disease (HD). mthtt 162-167 huntingtin Homo sapiens 150-160