PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15191682-2	2004	We have observed that there were close correlation among O6-Methylguanine-DNA methyltransferase (MGMT) enzyme activity, protein expression and cell resistance to alkylating agents especially to nitrosourea anti-tumor compounds by a series of experiments including cell survival, xenografts in nude mice, tumor patient biopsy and molecule biology assay.	Nitrosourea Compounds	194-205	O-6-methylguanine-DNA methyltransferase	Mus musculus	57-95	
18411412-0	2008	A new O6-alkylguanine-DNA alkyltransferase inhibitor associated with a nitrosourea (cystemustine) validates a strategy of melanoma-targeted therapy in murine B16 and human-resistant M4Beu melanoma xenograft models.	Nitrosourea Compounds	71-82	O-6-methylguanine-DNA methyltransferase	Mus musculus	6-42	
15191682-2	2004	We have observed that there were close correlation among O6-Methylguanine-DNA methyltransferase (MGMT) enzyme activity, protein expression and cell resistance to alkylating agents especially to nitrosourea anti-tumor compounds by a series of experiments including cell survival, xenografts in nude mice, tumor patient biopsy and molecule biology assay.	Nitrosourea Compounds	194-205	O-6-methylguanine-DNA methyltransferase	Mus musculus	97-101	
11023546-6	2000	Increased sensitivity of MGMT(-/-) mice to 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosou rea (ACNU), a bifunctional nitrosourea, was also noted.	Nitrosourea Compounds	140-151	O-6-methylguanine-DNA methyltransferase	Mus musculus	25-29	
7780976-2	1995	The DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) has been shown to repair nitrosourea-induced DNA damage.	Nitrosourea Compounds	94-105	O-6-methylguanine-DNA methyltransferase	Mus musculus	23-61	
7780976-2	1995	The DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) has been shown to repair nitrosourea-induced DNA damage.	Nitrosourea Compounds	94-105	O-6-methylguanine-DNA methyltransferase	Mus musculus	63-67	
7780976-3	1995	We therefore investigated the effect of expressing MGMT in hematopoietic cells (via retrovirus-mediated gene transfer) on nitrosourea-induced toxicity.	Nitrosourea Compounds	122-133	O-6-methylguanine-DNA methyltransferase	Mus musculus	51-55	
7780976-10	1995	These data suggest that MGMT expression in hematopoietic progenitor and precursor cells protects against nitrosourea-induced toxicity and that gene transfer may prove useful in attempts to reduce nitrosourea-induced myelosuppression in the clinical setting.	Nitrosourea Compounds	105-116	O-6-methylguanine-DNA methyltransferase	Mus musculus	24-28	
7780976-10	1995	These data suggest that MGMT expression in hematopoietic progenitor and precursor cells protects against nitrosourea-induced toxicity and that gene transfer may prove useful in attempts to reduce nitrosourea-induced myelosuppression in the clinical setting.	Nitrosourea Compounds	196-207	O-6-methylguanine-DNA methyltransferase	Mus musculus	24-28