PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31100090-0 2019 Protective effects of urocortin 2 against caerulein-induced acute pancreatitis. Ceruletide 42-51 urocortin 2 Rattus norvegicus 22-33 31100090-1 2019 Because little is known about the role of corticotropin-releasing factor (CRF) agonists in regulating responses in pancreatitis, we evaluated the effects of urocortin 2 (UCN2) and stressin1 in caerulein-induced acute pancreatitis (AP) model in rats. Ceruletide 193-202 urocortin 2 Rattus norvegicus 157-168 31100090-6 2019 NF-kappaB activity in pancreatic nuclear extracts increased in AP and UCN2 treatment reduced caerulein-induced increases in NF-kappaB activity by 42%. Ceruletide 93-102 urocortin 2 Rattus norvegicus 70-74 31100090-7 2019 UCN2 treatment prevented caerulein-induced degradation of IkappaB-alpha in the cytosolic fraction as well as increased levels of p65 subunit of NF-kappaB in the cytosolic fraction. Ceruletide 25-34 urocortin 2 Rattus norvegicus 0-4 31100090-9 2019 UCN2 evoked [Ca2+]i responses in primary acinar cells and abolished caerulein-evoked [Ca2+]i responses at 0.1nM, and decreased by ~50% at 1.0nM caerulein. Ceruletide 68-77 urocortin 2 Rattus norvegicus 0-4 31100090-9 2019 UCN2 evoked [Ca2+]i responses in primary acinar cells and abolished caerulein-evoked [Ca2+]i responses at 0.1nM, and decreased by ~50% at 1.0nM caerulein. Ceruletide 144-153 urocortin 2 Rattus norvegicus 0-4 31100090-11 2019 UCN2 prevented the massive redistribution of F-actin observed with supraphysiologic doses of caerulein. Ceruletide 93-102 urocortin 2 Rattus norvegicus 0-4