PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10518598-4	1999	Treatment of guard cell protoplasts with phosphatidic acid (PtdOH), one of the products of PLD activity, led to an inhibition of the activity of the inward K+ channel.	ptdoh	60-65	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	91-94	
25646564-3	2015	The lipid signaling molecule phosphatidic acid (PtdOH), which is produced by the hydrolytic enzyme phospholipase D (PLD), has been identified as a critical regulatory molecule for oncogenic signaling in many cancers.	ptdoh	48-53	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	99-114	
25646564-3	2015	The lipid signaling molecule phosphatidic acid (PtdOH), which is produced by the hydrolytic enzyme phospholipase D (PLD), has been identified as a critical regulatory molecule for oncogenic signaling in many cancers.	ptdoh	48-53	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	116-119	
17346796-6	2007	Thus, these data indicate that PLD-synthesised PtdOH stimulates the generation of PtdIns(4,5)P(2), which in turn mediates talin binding to, and activation of, CD11b/CD18 required for neutrophil stable adhesion and migration.	ptdoh	47-52	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	31-34	
28209987-2	2017	The phospholipase D (PLD) isoenzymes PLD1 and PLD2 are one of the major sources of signal-activated phosphatidic acid (PtdOH) generation downstream of a variety of cell-surface receptors, including G protein-coupled receptors (GPCRs), receptor tyrosine kinases (RTKs) and integrins.	ptdoh	119-124	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	4-19	
28209987-2	2017	The phospholipase D (PLD) isoenzymes PLD1 and PLD2 are one of the major sources of signal-activated phosphatidic acid (PtdOH) generation downstream of a variety of cell-surface receptors, including G protein-coupled receptors (GPCRs), receptor tyrosine kinases (RTKs) and integrins.	ptdoh	119-124	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	21-24	
28209987-5	2017	PLD enzymes were once thought to be undruggable owing to the ubiquitous nature of PtdOH in cell signalling and concerns that inhibitors would be too toxic for use in humans.	ptdoh	82-87	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3	
10518598-6	1999	Application of 1-butanol (1-buOH), a selective inhibitor of PtdOH production by PLD, inhibited the increase in PtdOH production elicited by ABA.	ptdoh	60-65	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	80-83	
10518598-6	1999	Application of 1-butanol (1-buOH), a selective inhibitor of PtdOH production by PLD, inhibited the increase in PtdOH production elicited by ABA.	ptdoh	111-116	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	80-83	
10518598-9	1999	These results suggest that in the guard cell, ABA activates the enzyme PLD, which leads to the production of PtdOH.	ptdoh	109-114	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	71-74	
8503884-3	1993	Our experiments suggest that phospholipase D (PLD)-mediated phosphatidylcholine (PtdCho) hydrolysis is the major source of both DG and PtdOH during the late signalling phase.	ptdoh	135-140	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	29-44	
9555059-5	1998	The observation that ethanol could significantly reduce [3H]PtdOH formation in myoblasts stimulated with BK and thrombin indicates that stimulation of PLD has a major role.	ptdoh	60-65	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	151-154	
8503884-3	1993	Our experiments suggest that phospholipase D (PLD)-mediated phosphatidylcholine (PtdCho) hydrolysis is the major source of both DG and PtdOH during the late signalling phase.	ptdoh	135-140	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	46-49	
8503884-10	1993	Thus, in angiotensin II-stimulated cultured vascular smooth-muscle cells, PLD-mediated PtdCho hydrolysis is the major source of sustained DG and PtdOH, whereas phosphoinositide breakdown is a minor contributor.	ptdoh	145-150	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	74-77	
8380986-5	1993	PtdCho-specific phospholipase D (PLD) activation was documented by the accumulation of [3H]phosphatidylethanol in cells prelabelled with [3H]myristic acid and stimulated in the presence of 1% (v/v) ethanol; this metabolic pathway, however, proved to be a minor one leading to generation of phosphatidic acid (PtdOH) during cell stimulation, whereas DG production by the sequential action of PtdCho-specific PLD and PtdOH phosphohydrolase was not observed.	ptdoh	309-314	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	16-31	
8380986-5	1993	PtdCho-specific phospholipase D (PLD) activation was documented by the accumulation of [3H]phosphatidylethanol in cells prelabelled with [3H]myristic acid and stimulated in the presence of 1% (v/v) ethanol; this metabolic pathway, however, proved to be a minor one leading to generation of phosphatidic acid (PtdOH) during cell stimulation, whereas DG production by the sequential action of PtdCho-specific PLD and PtdOH phosphohydrolase was not observed.	ptdoh	309-314	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	33-36