PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30552702-0	2019	p53 Up-regulated Modulator of Apoptosis Induction Mediates Acetaminophen-Induced Necrosis and Liver Injury in Mice.	Acetaminophen	59-72	BCL2 binding component 3	Mus musculus	0-39	
30552702-5	2019	PUMA deficiency suppressed APAP-induced mitochondrial dysfunction and release of cell death factors from mitochondria, and protected against APAP-induced hepatocyte necrosis and liver injury in mice.	Acetaminophen	27-31	BCL2 binding component 3	Mus musculus	0-4	
30552702-5	2019	PUMA deficiency suppressed APAP-induced mitochondrial dysfunction and release of cell death factors from mitochondria, and protected against APAP-induced hepatocyte necrosis and liver injury in mice.	Acetaminophen	141-145	BCL2 binding component 3	Mus musculus	0-4	
30552702-7	2019	Furthermore, a small-molecule PUMA inhibitor, administered after APAP treatment, mitigated APAP-induced hepatocyte necrosis and liver injury.	Acetaminophen	65-69	BCL2 binding component 3	Mus musculus	30-34	
30552702-7	2019	Furthermore, a small-molecule PUMA inhibitor, administered after APAP treatment, mitigated APAP-induced hepatocyte necrosis and liver injury.	Acetaminophen	91-95	BCL2 binding component 3	Mus musculus	30-34	
30552702-8	2019	Conclusion: Our results demonstrate that RIP1/JNK-dependent PUMA induction mediates AILI by promoting hepatocyte mitochondrial dysfunction and necrosis, and suggest that PUMA inhibition is useful for alleviating acute hepatotoxicity attributed to APAP overdose.	Acetaminophen	247-251	BCL2 binding component 3	Mus musculus	60-64	
30552702-8	2019	Conclusion: Our results demonstrate that RIP1/JNK-dependent PUMA induction mediates AILI by promoting hepatocyte mitochondrial dysfunction and necrosis, and suggest that PUMA inhibition is useful for alleviating acute hepatotoxicity attributed to APAP overdose.	Acetaminophen	247-251	BCL2 binding component 3	Mus musculus	170-174