PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23811004-0 2013 A novel upregulation of glutathione peroxidase 1 by knockout of liver-regenerating protein Reg3beta aggravates acetaminophen-induced hepatic protein nitration. Acetaminophen 111-124 regenerating islet-derived 3 beta Mus musculus 91-99 23811004-1 2013 Murine regenerating islet-derived 3beta (Reg3beta) represents a homologue of human hepatocarcinoma-intestine-pancreas/pancreatic-associated protein and enhances mouse susceptibility to acetaminophen (APAP)-induced hepatotoxicity. Acetaminophen 185-198 regenerating islet-derived 3 beta Mus musculus 41-49 23811004-1 2013 Murine regenerating islet-derived 3beta (Reg3beta) represents a homologue of human hepatocarcinoma-intestine-pancreas/pancreatic-associated protein and enhances mouse susceptibility to acetaminophen (APAP)-induced hepatotoxicity. Acetaminophen 200-204 regenerating islet-derived 3 beta Mus musculus 41-49 23811004-2 2013 Our objective was to determine if and how knockout of Reg3beta (KO) affects APAP (300 mg/kg, ip)-mediated protein nitration in mouse liver. Acetaminophen 76-80 regenerating islet-derived 3 beta Mus musculus 54-62 17133485-2 2006 HIP/PAP transgenic mice were protected against acetaminophen-induced acute liver failure and were stimulated to regenerate post-hepatectomy. Acetaminophen 47-60 regenerating islet-derived 3 beta Mus musculus 0-7 16116631-0 2005 HIP/PAP accelerates liver regeneration and protects against acetaminophen injury in mice. Acetaminophen 60-73 regenerating islet-derived 3 beta Mus musculus 4-7 16116631-7 2005 Second, we showed that 80% of the HIP/PAP-transgenic mice versus 25% of the control mice were protected against lethal acetaminophen-induced fulminate hepatitis. Acetaminophen 119-132 regenerating islet-derived 3 beta Mus musculus 38-41 16116631-9 2005 Comparison of Cu/Zn superoxide dismutase activity and glutathione reductase-like effects in control and transgenic liver mice indicated that HIP/PAP exerts an antioxidant activity and prevents reactive oxygen species-induced mitochondrial damage by acetaminophen overdose. Acetaminophen 249-262 regenerating islet-derived 3 beta Mus musculus 145-148