PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25222049-10	2014	Moreover, Bazhen decoction down-regulate acetaminophen-induced Bax/Bcl-2 ratio, caspase 3, caspase 8 and caspase 9.	Acetaminophen	41-54	BCL2-associated X protein	Mus musculus	63-66	
35559264-7	2022	MCGP also enhanced the number of PCNA-positive hepatocytes, increased hepatic PCNA and Bcl-XL, and decreased BAX expression in APAP-/CCl4-intoxicated mice.	Acetaminophen	127-131	BCL2-associated X protein	Mus musculus	109-112	
31967706-9	2020	Also, Irb mitigated APAP-induced inflammation in liver tissues via decreasing the expression of hepatic NF-kappaB, phosphorylated NF-kappaB and TNF-alpha, and attenuated hepatic apoptosis via decreasing Bax/Bcl-2 ratio and caspase 3 expression and activation.	Acetaminophen	20-24	BCL2-associated X protein	Mus musculus	203-206	
27599972-10	2017	Moreover, PBA significantly prevented APAP-induced Bax translocation to the mitochondria, and the expression of heme oxygenase-1 mRNA and 4-hydroxynonenal.	Acetaminophen	38-42	BCL2-associated X protein	Mus musculus	51-54	
28626497-6	2017	Western blot analysis revealed that FMF pretreatment significantly abrogated APAP-mediated phosphorylation of MAPKs, activation of proapoptotic protein caspase-3/9 and Bax, and restored expression of antiapoptotic protein Bcl2.	Acetaminophen	77-81	BCL2-associated X protein	Mus musculus	168-171	
35514074-9	2022	Furthermore, FA markedly reversed the APAP-induced decline of mitochondria membrane potential, increased ratio of BAX/BCL2 and CASPASE 3 expression, and promoted autophagy flux of hepatocytes by upregulating AMPK phosphorylation, which were abrogated by a specific AMPK inhibitor, compound C. Overall, the hepatoprotective effect of FA on APAP-induced ALI might be associated with anti-oxidant and anti-apoptosis, which were at least partly attributed to AMPK-mediated protective autophagy.	Acetaminophen	38-42	BCL2-associated X protein	Mus musculus	114-117	
35369900-7	2022	Moreover, Ori regulated APAP-induced hepatocyte apoptosis and mitochondrial dysfunction by inhibiting cytochrome c mitochondrial translocation and c-jun N-terminal kinase phosphorylation, promoting Bcl-2 expression and reducing Bax and caspase-3 cleavage.	Acetaminophen	24-28	BCL2-associated X protein	Mus musculus	228-231	
29574133-7	2018	Furthermore, kaempferol markedly attenuated APAP-induced serum TNF-alpha and IL-6 productions, downregulated APAP-induced phosphorylations of JNK and ERK, and decreased early hepatic apoptosis via decreasing Bax/Bcl-2 ratio and caspase 3 activation.	Acetaminophen	44-48	BCL2-associated X protein	Mus musculus	208-211	
29574133-7	2018	Furthermore, kaempferol markedly attenuated APAP-induced serum TNF-alpha and IL-6 productions, downregulated APAP-induced phosphorylations of JNK and ERK, and decreased early hepatic apoptosis via decreasing Bax/Bcl-2 ratio and caspase 3 activation.	Acetaminophen	109-113	BCL2-associated X protein	Mus musculus	208-211	
26807019-7	2016	Western blot analysis showed that CA abrogated APAP-induced cleaved caspase-3, Bax and phosphorylated JNK protein expression.	Acetaminophen	47-51	BCL2-associated X protein	Mus musculus	79-82	
17906064-0	2008	Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity.	Acetaminophen	101-114	BCL2-associated X protein	Mus musculus	14-17	
24259976-10	2013	Furthermore, CMN treatment efficiently protected against APAP-induced apoptosis via increasing Bcl-2/Bax ratio.	Acetaminophen	57-61	BCL2-associated X protein	Mus musculus	101-104	
23272189-9	2012	In addition, melatonin inhibited APAP-induced hepatic c-Jun N-terminal kinase (JNK) phosphorylation and mitochondrial Bax translocation.	Acetaminophen	33-37	BCL2-associated X protein	Mus musculus	118-121	
17906064-3	2008	APAP overdose induced Bax translocation from the cytosol to the mitochondria as early as 1 h after APAP injection.	Acetaminophen	0-4	BCL2-associated X protein	Mus musculus	22-25	
17906064-3	2008	APAP overdose induced Bax translocation from the cytosol to the mitochondria as early as 1 h after APAP injection.	Acetaminophen	99-103	BCL2-associated X protein	Mus musculus	22-25