PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23339700-3 2012 APAP administration significantly increased the levels of serum urea, creatinine, and renal lipid peroxidation (LPO), whereas substantial decreases were observed in levels of glutathione (GSH), adenosine triphosphatase (ATPase), superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), and glutathione peroxidase (GPx) enzymatic activities after APAP administration. Acetaminophen 0-4 glutathione-disulfide reductase Rattus norvegicus 273-294 22120977-5 2014 In Phase-I, acetaminophen caused further GSH depletion and reduction in SOD, catalase, GPx and GR activities, but in Phase-II, only GPx and GR activities were more affected. Acetaminophen 12-25 glutathione-disulfide reductase Rattus norvegicus 95-97 23339700-3 2012 APAP administration significantly increased the levels of serum urea, creatinine, and renal lipid peroxidation (LPO), whereas substantial decreases were observed in levels of glutathione (GSH), adenosine triphosphatase (ATPase), superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), and glutathione peroxidase (GPx) enzymatic activities after APAP administration. Acetaminophen 0-4 glutathione-disulfide reductase Rattus norvegicus 296-298 21219961-3 2011 Acetaminophen enhanced arsenic-induced lipid peroxidation, GSH depletion and ROS production and further decreased superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activities. Acetaminophen 0-13 glutathione-disulfide reductase Rattus norvegicus 173-194 19782400-9 2010 Arsenic or acetaminophen given alone depleted GSH and decreased the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase and these effects remained mostly unaffected after co-exposure. Acetaminophen 11-24 glutathione-disulfide reductase Rattus norvegicus 138-159 18380536-9 2009 GR activity was decreased already after 3 h of incubation and remained also decreased in cells treated with 2.5, 5, 10 and 20 mM AAP during further incubation. Acetaminophen 129-132 glutathione-disulfide reductase Rattus norvegicus 0-2 15707775-5 2005 Activity of the antioxidant enzymes in the liver inhibited by APAP was increased in the majority of groups after administration of the substances tested: catalase (CAT) by 55%, glutathione peroxidase (GPx) by 50%, glutathione reductase (GR) by 35% and glutathione S-transferase (GST) by 60%. Acetaminophen 62-66 glutathione-disulfide reductase Rattus norvegicus 214-235 15875720-3 2005 Paracetamol administration significantly reduced hepatic glycogen, glutathione (GSH), glutathione-S-transferase (GST), glutathione peroxidase (GPX) and glutathione reductase (GSH-R). Acetaminophen 0-11 glutathione-disulfide reductase Rattus norvegicus 152-173 15707775-5 2005 Activity of the antioxidant enzymes in the liver inhibited by APAP was increased in the majority of groups after administration of the substances tested: catalase (CAT) by 55%, glutathione peroxidase (GPx) by 50%, glutathione reductase (GR) by 35% and glutathione S-transferase (GST) by 60%. Acetaminophen 62-66 glutathione-disulfide reductase Rattus norvegicus 237-239 10918522-8 2000 Resistance to acetaminophen hepatotoxicity produced by repeated exposure is partially attributable to upregulation of hepatic G6PD and GR activity as an adaptive and protective response to oxidative stress and glutathione depletion. Acetaminophen 14-27 glutathione-disulfide reductase Rattus norvegicus 135-137 31020376-7 2019 Lipid peroxidation, glutathione reductase and superoxide dismutase levels were increased in the plasma and arteries of the APAP group. Acetaminophen 123-127 glutathione-disulfide reductase Rattus norvegicus 20-41 8200258-6 1994 Pretreatment with both diethyl maleate, which covalently binds glutathione as catalyzed by glutathione-S-transferase, and bis(chloroethyl)-nitrosourea, an inhibitor of glutathione reductase, enhanced acetaminophen-induced cytotoxicity. Acetaminophen 200-213 glutathione-disulfide reductase Rattus norvegicus 168-189 7558183-3 1995 However, no change was observed in the activity of glutathione reductase (GR) after acetaminophen treatment, while acetaminophen plus vitamin E treated rats showed significant increase in GR activity. Acetaminophen 115-128 glutathione-disulfide reductase Rattus norvegicus 188-190 3977907-3 1985 Inhibition of glutathione reductase by 50 uM bis-chloro-nitrosourea, shown previously to increase the sensitivity of hepatocytes to an oxidative stress, potentiated the toxicity of acetaminophen without increasing the covalent binding of acetaminophen metabolites. Acetaminophen 181-194 glutathione-disulfide reductase Rattus norvegicus 14-35 3977907-3 1985 Inhibition of glutathione reductase by 50 uM bis-chloro-nitrosourea, shown previously to increase the sensitivity of hepatocytes to an oxidative stress, potentiated the toxicity of acetaminophen without increasing the covalent binding of acetaminophen metabolites. Acetaminophen 238-251 glutathione-disulfide reductase Rattus norvegicus 14-35 28255865-7 2017 The activities of both CAT (catalase) and GR (glutathione reductase) enzymes after the toxic dose of paracetamol were significantly increased in the liver homogenates, compared to control group. Acetaminophen 101-112 glutathione-disulfide reductase Rattus norvegicus 42-44 28255865-7 2017 The activities of both CAT (catalase) and GR (glutathione reductase) enzymes after the toxic dose of paracetamol were significantly increased in the liver homogenates, compared to control group. Acetaminophen 101-112 glutathione-disulfide reductase Rattus norvegicus 46-67 27220627-6 2017 APAP overdose induced significant elevations in liver function biomarkers, hepatic lipid peroxidation, hepatic catalase, and superoxide dismutase (SOD), decreased the reduced glutathione (GSH) content and glutathione reductase (GR) activity, and stimulated significant DNA damage in hepatocytes, compared to control rats. Acetaminophen 0-4 glutathione-disulfide reductase Rattus norvegicus 205-226 27220627-6 2017 APAP overdose induced significant elevations in liver function biomarkers, hepatic lipid peroxidation, hepatic catalase, and superoxide dismutase (SOD), decreased the reduced glutathione (GSH) content and glutathione reductase (GR) activity, and stimulated significant DNA damage in hepatocytes, compared to control rats. Acetaminophen 0-4 glutathione-disulfide reductase Rattus norvegicus 228-230