PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9625528-9	1998	Treatment of the RTS cell line with acetyl-Asp-Glu-Val-Asp-aldehyde (Ac-DEVD-CHO), a specific inhibitor of caspase-3, significantly increased the cell viability after CH-11 treatment (75.9% +/- 2.2%).	4-dimethylamino-3',4'-dimethoxychalcone	167-172	caspase 3	Homo sapiens	107-116	
18566385-2	2008	In the rho0 cells treated with CH-11, ATP supplementation converted necrosis into apoptosis by the formation of the apoptosome and subsequent activation of procaspase-3.	4-dimethylamino-3',4'-dimethoxychalcone	31-36	caspase 3	Homo sapiens	156-168	
12845662-3	2003	An increase in caspase-3 and -8 activities was then observed by the addition of agonistic anti-Fas antibody, CH-11.	4-dimethylamino-3',4'-dimethoxychalcone	109-114	caspase 3	Homo sapiens	15-31	
14532729-7	2003	Also, 15d-PGJ2 alone did not activate caspase-3, but CH11 and 15d-PGJ2 synergistically activated caspase-3.	4-dimethylamino-3',4'-dimethoxychalcone	53-57	caspase 3	Homo sapiens	97-106	
24128051-8	2014	Moreover, gemcitabine increased CH11-induced caspase-8 and caspase-3 cleavage and proteolytic activity.	4-dimethylamino-3',4'-dimethoxychalcone	32-36	caspase 3	Homo sapiens	59-68	
23129783-6	2013	In NHBE cells, both SM (300 microM) and CH11 (100 ng/ml) induced caspase-3 activation, which was inhibited by FasR siRNA and ZB4, indicating that SM-induced apoptosis was via the Fas response.	4-dimethylamino-3',4'-dimethoxychalcone	40-44	caspase 3	Homo sapiens	65-74	
12670900-4	2003	Both caspase-3 and caspase-8 activities were increased by anti-Fas antibody CH-11 only in cells at 32.5 degrees C with wild-type p53.	4-dimethylamino-3',4'-dimethoxychalcone	76-81	caspase 3	Homo sapiens	5-14