PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26101579-0 2015 Leveraging the Pre-DFG Residue Thr-406 To Obtain High Kinase Selectivity in an Aminopyrazole-Type PAK1 Inhibitor Series. 3-aminopyrazole 79-92 p21 (RAC1) activated kinase 1 Homo sapiens 98-102 26101579-1 2015 To increase kinase selectivity in an aminopyrazole-based PAK1 inhibitor series, analogues were designed to interact with the PAK1 deep-front pocket pre-DFG residue Thr-406, a residue that is hydrophobic in most kinases. 3-aminopyrazole 37-50 p21 (RAC1) activated kinase 1 Homo sapiens 57-61 26101579-1 2015 To increase kinase selectivity in an aminopyrazole-based PAK1 inhibitor series, analogues were designed to interact with the PAK1 deep-front pocket pre-DFG residue Thr-406, a residue that is hydrophobic in most kinases. 3-aminopyrazole 37-50 p21 (RAC1) activated kinase 1 Homo sapiens 125-129