PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34140067-1	2021	Objective To explore the role of transient receptor potential melastatin 8 (TRPM8) in the expression of airway epithelial-derived cytokines interleukin 25 (IL-25), IL-33 and thymic stromal lymphopoietin (TSLP) in human bronchial epithelial BEAS-2B cells induced by menthol and its related signal transduction mechanism.	Menthol	265-272	thymic stromal lymphopoietin	Homo sapiens	174-202	
34140067-12	2021	Both BAPTA-AM and PDTC could inhibit the high expression of IL-25, IL-33 and TSLP induced by menthol.	Menthol	93-100	thymic stromal lymphopoietin	Homo sapiens	77-81	
34140067-13	2021	Conclusion Menthol can induce the secretion of IL-25, IL-33 and TSLP in human BEAS-2B cells by activating TRPM8 which leads to increased Ca2+ concentration and activation of the NF-kappaB pathway.	Menthol	11-18	thymic stromal lymphopoietin	Homo sapiens	64-68	
34140067-1	2021	Objective To explore the role of transient receptor potential melastatin 8 (TRPM8) in the expression of airway epithelial-derived cytokines interleukin 25 (IL-25), IL-33 and thymic stromal lymphopoietin (TSLP) in human bronchial epithelial BEAS-2B cells induced by menthol and its related signal transduction mechanism.	Menthol	265-272	thymic stromal lymphopoietin	Homo sapiens	204-208	
34140067-10	2021	Results Compared with the blank control group, the mRNA and protein expression of IL-25, IL-33 and TSLP, the level of Ca2+, and the protein expression of NF-kappaB p65 were significantly up-regulated in the menthol group.	Menthol	207-214	thymic stromal lymphopoietin	Homo sapiens	99-103	
34140067-11	2021	After knock-down of TRPM8, the menthol-induced increases of Ca2+, IL-25, IL-33, TSLP and NF-kappaB p65 expression were inhibited.	Menthol	31-38	thymic stromal lymphopoietin	Homo sapiens	80-84	
32400133-8	2020	RESULTS: Treatment with up to 2 mM menthol dose-dependently increased TRPM8 mRNA and protein in BEAS2B cells compared to untreated cells (P < 0.001) and concomitantly increased IL-25 and TSLP mRNA (P < 0.05), but not IL-33 mRNA.	Menthol	35-42	thymic stromal lymphopoietin	Homo sapiens	187-191	
32400133-9	2020	BCTC (10 muM) significantly abolished menthol-induced up-regulation of TRPM8 mRNA and protein and IL-25 and TSLP mRNA (P < 0.01).	Menthol	38-45	thymic stromal lymphopoietin	Homo sapiens	108-112