PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24775307-6 2014 Using proprietary methodology, the high-affinity pyridine or imidazole metal-binding group found in current clinical CYP17 inhibitors was replaced with novel, less avid, metal-binding groups in concert with potency-enhancing molecular scaffold modifications. pyridine 49-57 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 117-122 30108986-3 2018 Pyridine fusion to position 3,4 of the A-ring may dramatically enhance affinity of 17alpha-picolyl compounds for CYP17 while conferring selective antiproliferative activity against PC-3 cells. pyridine 0-8 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 113-118