PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20205396-4	2010	Studies of the binding of various substrates (pyridine, dmso, ethylene and methyl acrylate) to 3-meso and 3-rac show that hindered displacement of the chelating carbonyl moiety by pi-coordination of incoming monomer significantly retards, but does not prohibit, polymerization.	pyridine	46-54	AKT serine/threonine kinase 1	Homo sapiens	108-111	
28150530-8	2018	The binding affinities of these seven compounds on AKT1 and AKT3 isoforms were mainly determined by hydrophobic contributions between the aromatic portion at position 4 of the pyridine ring with residues Phe236/234, Phe237/235, Phe438/435, and Phe442/439 in the ATP binding pocket.	pyridine	176-184	AKT serine/threonine kinase 1	Homo sapiens	51-55	
20006497-0	2010	2,3,5-Trisubstituted pyridines as selective AKT inhibitors-Part I: Substitution at 2-position of the core pyridine for ROCK1 selectivity.	pyridine	21-29	AKT serine/threonine kinase 1	Homo sapiens	44-47	
16678413-2	2006	Modifications at the 3 position of the pyridine ring led to a number of potent compounds with improved physical properties, resulting in the identification of 11g as a promising, orally active Akt inhibitor.	pyridine	39-47	AKT serine/threonine kinase 1	Homo sapiens	193-196	
34854518-2	2022	In the present study, we found that SC66, a pyridine-based allosteric Akt inhibitor, suppressed basal and H2 O2 -induced autophagy concurrent with decreased phosphorylation and activity of AMPK.	pyridine	44-52	AKT serine/threonine kinase 1	Homo sapiens	70-73	
30477412-4	2019	This work describes the computational search for new inhibitors using a hit optimization process of the previously reported AKT pan inhibitor, a 2,4,6-trisubstituted pyridine.	pyridine	166-174	AKT serine/threonine kinase 1	Homo sapiens	124-127