PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11738601-1 2002 Bioisosteric replacement of the pyridine pharmacophoric element in (+/-)-pyrido[3.4-b]homotropane (PHT) and pyrido[3.4-b]tropane with the pyridazine and pyrimidine nucleus resulted in hitherto unknown nAChR ligands such as 5-8. pyridine 32-40 cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus 201-206 9733494-2 1998 Here we report the synthesis and in vitro nAChR binding of a series of 10 pyridine-modified analogues of A-85380. pyridine 74-82 cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus 42-47