PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8334118-10 1993 Comparisons show that, while NADP+ and NADPH bind to DHFR with the pyridine ring and 3"-carboxamide coplanar, the thioamide group is twisted by 23 degrees from the pyridine plane in both the binary and ternary complexes. pyridine 67-75 dihydrofolate reductase Gallus gallus 53-57