PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31724854-1	2019	Nicotinamide N-methyltransferase (NNMT) catalyzes the methyl transfer from the cofactor S-adenosylmethionine to nicotinamide and other pyridine-containing compounds.	pyridine	135-143	nicotinamide N-methyltransferase	Homo sapiens	0-32	
31724854-1	2019	Nicotinamide N-methyltransferase (NNMT) catalyzes the methyl transfer from the cofactor S-adenosylmethionine to nicotinamide and other pyridine-containing compounds.	pyridine	135-143	nicotinamide N-methyltransferase	Homo sapiens	34-38	
30148963-1	2018	Nicotinamide N-methyltransferase (NNMT) catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, pyridine, and other structural analogues.	pyridine	130-138	nicotinamide N-methyltransferase	Homo sapiens	0-32	
30349486-1	2018	Background: Nicotinamide N-methyltransferase (NNMT) is an enzyme that catalyzes N-methylation of pyridine-containing compounds.	pyridine	97-105	nicotinamide N-methyltransferase	Homo sapiens	12-44	
30349486-1	2018	Background: Nicotinamide N-methyltransferase (NNMT) is an enzyme that catalyzes N-methylation of pyridine-containing compounds.	pyridine	97-105	nicotinamide N-methyltransferase	Homo sapiens	46-50	
30933557-5	2019	These compounds, which include 4-chloropyridine and 4-chloronicotinamide, exploit the broad substrate scope of NNMT; methylation of the pyridine nitrogen enhances the electrophilicity of the C4 position, thereby promoting an aromatic nucleophilic substitution by C159, a noncatalytic cysteine.	pyridine	39-47	nicotinamide N-methyltransferase	Homo sapiens	111-115	
30148963-1	2018	Nicotinamide N-methyltransferase (NNMT) catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, pyridine, and other structural analogues.	pyridine	130-138	nicotinamide N-methyltransferase	Homo sapiens	34-38	
29320176-1	2018	Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of pyridine-containing compounds using the cofactor S-5"-adenosyl-l-methionine (SAM) as the methyl group donor.	pyridine	71-79	nicotinamide N-methyltransferase	Homo sapiens	0-32	
29420365-1	2018	Nicotinamide N-methyltransferase (NNMT) is an enzyme that catalyzes the N-methylation of nicotinamide and pyridine compounds, participating in xenobiotic and drug metabolism.	pyridine	106-114	nicotinamide N-methyltransferase	Homo sapiens	0-32	
29420365-1	2018	Nicotinamide N-methyltransferase (NNMT) is an enzyme that catalyzes the N-methylation of nicotinamide and pyridine compounds, participating in xenobiotic and drug metabolism.	pyridine	106-114	nicotinamide N-methyltransferase	Homo sapiens	34-38	
29320176-1	2018	Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of pyridine-containing compounds using the cofactor S-5"-adenosyl-l-methionine (SAM) as the methyl group donor.	pyridine	71-79	nicotinamide N-methyltransferase	Homo sapiens	34-38	
11154840-2	2001	Nicotinamide N-methyltransferase (NNMT) catalyzes N-methylation of nicotinamide and other pyridines to form pyridinium ions.	pyridine	108-118	nicotinamide N-methyltransferase	Homo sapiens	0-32	
27389312-3	2016	It has been proposed that NNMT may possess beta-carboline (BC) N-methyltransferase activity, endogenously and exogenously produced pyridine-containing compounds which, when N-methylated, are potent inhibitors of Complex I and have been proposed to have a role in the pathogenesis of Parkinson"s disease.	pyridine	131-139	nicotinamide N-methyltransferase	Homo sapiens	26-30	
27570878-2	2016	Employing the cofactor S-adenosyl-l-methionine, NNMT transfers a methyl group to the pyridine nitrogen of nicotinamide to generate N-methylnicotinamide.	pyridine	85-93	nicotinamide N-methyltransferase	Homo sapiens	48-52	
27570878-3	2016	Interestingly, NNMT is also able to N-methylate a variety of other pyridine-containing small molecules, suggesting a secondary role for the enzyme in the detoxification of xenobiotics.	pyridine	67-75	nicotinamide N-methyltransferase	Homo sapiens	15-19	
27570878-7	2016	We successfully demonstrated the general applicability of the method by performing kinetic analyses of NNMT-mediated methylation for a range of pyridine-based substrates.	pyridine	144-152	nicotinamide N-methyltransferase	Homo sapiens	103-107	
11154840-2	2001	Nicotinamide N-methyltransferase (NNMT) catalyzes N-methylation of nicotinamide and other pyridines to form pyridinium ions.	pyridine	108-118	nicotinamide N-methyltransferase	Homo sapiens	34-38	
2311261-1	1990	Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide, pyridine, and structurally related compounds.	pyridine	85-93	nicotinamide N-methyltransferase	Homo sapiens	0-32	
2311261-1	1990	Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide, pyridine, and structurally related compounds.	pyridine	85-93	nicotinamide N-methyltransferase	Homo sapiens	34-38	
2311261-11	1990	It will now be possible to test the hypothesis that individual differences in hepatic NNMT activity might be related to variation in the N-methylation of pyridine compounds and to individual differences in either toxicity or the therapeutic efficacy of such compounds.	pyridine	154-162	nicotinamide N-methyltransferase	Homo sapiens	86-90